HOSPITAL OF THE NORTH SHORE- LONG ISLAND JEWISH HEALTH SYSTEM
Trachtman H. 2003
The protective effect of curcumin against (toxin)- induced injury…was not related to its antioxidant properties. Instead, curcumin enhanced expression of heat shock protein… PMID: 11322764- 3 Researchers
DEPARTMENT OF ONCOLOGY, Augenlicht LH. 2003
The butyrate response was compared in detail with…curcumin, a component of mustard and curry structurally and functionally related to sulindac that also has chemopreventive activitiy. PMID: 10969808- 3 Researchers

AMERICAN HEALTH FOUNDATION
CHEMOPREVENTION PROGRAM
Reddy BS. 1999
Curcumin inhibited colonic (tumor) formation (in an animal modeo) by 45%. PMID: 10223193- 4 Researchers

AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1999
Thus, chemopreventive activity of curcumin is observed when it is administered prior to, during, and after carcinogen treatment as well as when it is given only during the promotion/progression phase (starting late in premalignant stage) of colon carcinogenesis. PMID: 9973206- 7 Researchers

AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1995
The results indicate that dietary administration of curcumin significantly inhibited incidence of colon adenocarcinomas and the multiplicity of invasive, noninvasive, and total (invasive plus noninvasive) adenocarcinomas. Dietary curcumin also significantly suppressed the colon tumor volume by >57% compared to the control diet. Although the precise mechanism by which curcumin inhibits colon tumorigenesis remains to be elucidated, it is likely that the chmopreventive action, at leasat in part, may be related to the modulation of arachidonic acid metabolism (the pathway that also leads to inflammatory COX- 2). PMID: 7812955- 5 Researchers

AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1993
The results of the present study indicate that curcumin, present in turmeric, inhibits AOM- induced colonic preneoplastic lesions and other cellular events relevant to colon carcinogenesis. PMID: 8242846- 3 Researchers

BAYLOR COLLEGE OF MEDICINE
THE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
Tan TH. 1998
Curcumin, a dietary pigment in curry, suppresses tumor initiation and tumor promotion.... Taken together, the inhibition of the MEKK1- JNK pathway reveals a possible mechanism of suppression of AP- 1 and NF- kappaB signaling (proteins overexpressed in pathological inflammation and cancer states) by curcumin, and may explain the potent anti- inflammatory and anti- carcinogenic effects of this chemical. PMID: 9674701- 2 Researchers

CANCER RESEARCH CENTER OF HAWAII
ETIOLOGY PROGRAM
Cooney RV. 1999
Heterocyclic aromatic amines (HAAs), a group of chemicals formed during high- temperature cooking of meat and fish, are potent mutagens and are suspected to play a role in colorectal (and just about every other form of) cancer.Lower levels of PhIP and MeIQx were observed in meat marinated with turmeric- garlic sauce. In contrast, marinating with barbecue sauce caused a 2.9- and 1.9- fold increase in PhIP and a 4- and 2.9- fold increase in MeIQx PMID: 10578481- 3 Researchers

COLUMBIA UNIVERSITY
COLLEGE OF PHYSICIANS AND SURGEONS
Katz AE. 2001
Curcumin causes a marked decrease in the extent of cell proliferation…and…could be a potentially therapeutic anti- cancer agent, as it significantly inhibits prostate cancer growth,…and has the potential to prevent the progression of prostate cancer to its hormone refractory state.
PMID: 11398177- 5 Researchers

COLUMBIA UNIVERSITY
COLLEGE OF PHYSICIANS AND SURGEONS
Katz AE. 2000
These results, taken together with our previous results that curcumin can induce apoptosis in both androgen- dependent and androgen- independent prostate cancer cells, support our view that curcumin may be a novel modality by which one can interfere with the signal transduction pathways of the prostate cancer cell and prevent it from progressing to its hormone- refractory state.
PMID: 10851300 - 3 Researchers

CORNELL UNIVERSITY
THE NEW YORK HOSPITAL- CORNELL MEDICAL CENTER
Bertagnolli MM. 2000
These data (approximately 63% decreased adenoma tumor formation) place the plant phenolics CAPE and curcumin among a growing list of anti- inflammatory agents that suppress Apc- associated intestinal carcinogenesis. PMID: 10783313- 8 Researchers

CORNELL UNIVERSITY
DR. MITCHELL GAYNORE, MEDICAL DIRECTOR. 2001
Although there is abundant science to support the potential of nutritional therapies such as the natural COX- 2 inhibitors found in red wine and turmeric and the phytoestrogens, in soy for cancer prevention, few doctors are aware of this information.
DEPARTMENT OF SURGERY, Bertagnolli MM. 2000
These results show that mucosal…T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte- mediated immune functions. PMID: 10729246- 4 Researchers

CORNELL UNIVERSITY
DEPARTMENT OF CARDIOTHORACIC SURGERY
Dannenberg AJ. 1999
We found that curcumin directly inhibited the activity of COX- 2. These data provide new insights into the anticancer properties of curcumin. PMID: 10190560- 5 Researchers

CORNELL UNIVERSITY
DEPARTMENT OF MEDICINE
Rigas B. 1997
Curcumin, the active ingredient of the rhizome of the plant turmeric (Curcuma longa Linn), a commonly used spice, prevents cancer in animal tumor models. The role of curcumin’s antiproliferative effect in human colon cancer remains to be established. PMID: 9422331- 4 Researchers

CORNELL UNIVERSITY
CORNELL CANCER RESEARCH LABORATORY
Nitin T. Telang, 1994
Curcumin, despite being an antioxidant, is also a non- steroidal anti- inflammatory agent. It is probable that curcumin may selectively kill clones of tumor cells, as has been reported. 1 Researcher

CORNELL UNIVERSITY
DEPARTMENT OF INTERNAL MEDICINE
Awasthi YC. 1999
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa), has been shown to inhibit chemical carcinogenesis in animal models and has been shown to be an anti- inflammatory agent… These results suggest that GSTs play a major role in detoxification of lipid peroxidation products…and that these enzymes are modulated by curcumin. PMID: 10514034- 7 Researchers

EMORY UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PHARMACOLOGY
Pavlath GK. 1999
Skeletal muscle is often the site of tissue injury due to trauma, disease, developmental defects or surgery. Yet, to date, no effective treatment is available to stimulate the repair of skeletal muscle…Systemic administration of the NF- kB inhibitor curcumin stimulates muscle regneration after traumatic injury. The striking effects of curcumin on myogenesis suggest therapeutic applications for treating muscle injuries. PMID: 10444409- 5 Researchers

EMORY UNIVERSITY SCHOOL OF MEDICINE
DIVISION OF CARDIOLOGY
Medford RM. 1998
(Curcumin was also found to inhibit TNF activated VCAM- 1, a pathway which can lead to pathological inflammation and is implicated in atherosclerosis). PMID: 9468519- 3 Researchers

FLORIDA A&M UNIVERSITY
COLLEGE OF PHARMACY AND PHARMACEUTICAL SCIENCES
Mazzio EA. 1998
Excessive nitric oxide (NO) production in the brain has been correlated with neurotoxicity and the pathogenesis of several neurodegenerative diseases. (Curcumin and other plant compounds were shown to significantly inhibit this potentially problematic imbalance). PMID: 9714085- 2 Researchers

UCLA MEDICAL CENTER
Shoskes DA. 2000
The combination of mycophenolic acid with curcumin…reduces rental injury and facilitates repair. PMID: 10688038- 2 Researchers

UCLA MEDICAL CENTER
DEPARTMENT OF SURGERY, UCLA SCHOOL OF MEDICINE
Shoskes DA. 1998
curcumin reduce ischemia- reperfusion (blood flow obstructed) injury and its inflammatory sequelae. The bioflavonoids (curcumin) holds promise as agents that can reduce immune and nonimmune renal injury, the key risk factors in chronic graft loss. PMID: 9701255- 1 Researcher

HARVARD MEDICAL SCHOOL
Freeman MR. 1999
[This group is looking at the relationship between curcumin, AP- 1 (a key player in the inflammatory cascade) and bladder muscle health]. PMID: 10444406- 7 Researchers

HARVARD MEDICAL SCHOOL
DEPARTMENT OF DERMATOLOGY
Byers HR 1998
These results indicate that curcumin has direct antiangiogenic activity in vitro and in vivo. The activity of curcumin in inhibiting carcinogenesis in diverse organs such as the skin and colon may be mediated in part through angiogenesis inhibition. PMID: 10780880- 8 Researchers

HENRY FORD HOSPITAL
DEPARTMENT OF MEDICINE
Chapman RA. 1998
We have investigated the antiproliferative effect of curcumin, an antitumor agent with antioxidant and anti- inflammatory properties...These findings have implications for developing curcumin- based anticancer and anti- inflammation therapies. PMID: 9719490- 5 Researchers

HENRY FORD HOSPITAL
DIVISION OF HEMATOLOGY/ONCOLOGY
Gautam SC. 1997- 98
(Curcumin was also found to inhibit aspects of the NF- Kappa B cascade, a pathway which can lead to pathological inflammation and cancer proliferation). PMID: 9439980- 5 Researchers.

HENRY FORD HOSPITAL
DEPARTMENT OF INTERNAL MEDICINE
Gautam SC. 1997- 98
(This group of scientists from Henry Ford Hospital are investigating curcumins role as an anti- inflammatory in this most complex biochemical pathway). PMID: 9168063- 6 Researchers

MANHATTAN EYE, EAR AND THROAT HOSPITAL
DEPARTMENT OF OTOLARYNGOLOGY
Schantz SP. 1998
(Curcumin and other agents were found to inhibit two cell lines of head and neck squamous cell carcinomas). PMID: 9482545- 5 Researchers

MEDICAL COLLEGE OF OHIO
DEPARTMENTS OF UROLOGY AND PATHOLOGY
Selman SH. 2002
The development of an effective nontoxic agent that may be used immediately after bladder tumor resection to prevent the implantation of tumor cells would be a significant clinical advancement…curcumin is a potent cytotoxic agent against (multiple) bladder tumor cell lines. Curcumin effectively inhibits tumor implantation and growth in this murine bladder tumor model. PMID: 11547120- 5 Researchers

MEMORIAL SLOAN- KETTERING CANCER CENTER
DEPARTMENT OF SURGERY, HEAD AND NECK SURGERY
Sacks PG. 1998
Combinations allowed for a dose reduction of 4.4- 8.5- fold for EGCG and 2.2- 2.8- fold for curcumim. EGCG and curcumin were noted to inhibit neoplastic growth by different mechanisms, a factor which may account for their demonstrable interactive synergistic effect. PMID: 9525275 – 5 Researchers

MEMORIAL SLOAN- KETTERING CANCER CENTER
SCHANTZ S. 1997
Effective chemoprevention of aerodigestive tumors could have far- reaching effects. Aerodigestive cancer accounts for one- third of all cancer deaths in the United States and is the most common cancer in some areas of the world...Novel agents are under development (especially for heavy smokers): epigallacatchin gallate, or green tea, curcumin, and a new emphasis on folic acid. PMID: 9433643- 2 Researchers

MERCY CANCER INSTITUTE
CANCER RESEARCH LIBRARY
Zaren HA 1998
Results of the present study suggest that curcumin may inhibit BaP- induced forestomach cancer in mice by affecting both activation as well as inactivation pathways of BaP metabolism in the liver...Therefore, it seems reasonable to postulate that curcumin may exert anticarcinogenic activity either by inhibiting activation of BaP or (and) by enhancing the detoxification of (+)- anti- BaPDE (the metabolite of BaP that is highly carcinogenic). PMID: 9744529- 7 Researchers

MICHIGAN STATE UNIVERSITY
DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY AND TOXICOLOGY CENTER
Nair MG. 2000
(Curcuminoids) from Cucuma longa were assayed for their cytotoxicity, antioxidant and anti- inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. Curcumins I- III also showed good inhibition of the COX- II enzyme…PMID: 10969724- 3 Researchers

MICHIGAN STATE UNIVERSITY
DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY AND TOXICOLOGY CENTER
Nair MG. 1998
…three curcuminoids displayed topoisomerase I and II enzyme inhibition activity (an imbalance or excess in topoisomerase enzyme activity, the enzyme responsible for breaking and repairing DNA, is believed at the root of many cancer processes). PMID: 9584408- 3 Researchers

NATIONAL CANCER INSTITUTE
DIVISION OF CANCER PREVENTION
Sigman CC. 2000
Numerous diet- derived agents are included among the >40 promising agents and agent combinations that are being evaluated clinically as chemopreventive agents for major cancer targets including breast, prostate, colon and lung. Examples include green and black tea…curcumin…PMID: 10721931- 13 Researchers

NATIONAL CANCER INSTITUTE
LABORATORY OF CELLULAR AND MOLECULAR BIOLOGY
Boone CW. 1998
(Researchers concluded curcumin and green/black tea extracts prevented radiation induced DNA damage). PMID: 9858893- 7 Researchers

NATIONAL CANCER INSTITUTE
DIVISION OF BASIC SCIENCES
Pommier Y. 1997
(The NCI has been investigating curcumin for specific activities against HIV). PMID: 9301668- 7 Researchers

NATIONAL CANCER INSTITUTE
DIVISION OF CANCER PREVENTION AND CONTROL (DCPC),
Sigman CC. 1996
(Curcumin is one of a number of plant compounds that are under investigation by the Division of Cancer Prevention and Control (DCPC) of the National Cancer Institute as a “promising chemopreventive agent.” PMID: 9154168- 25 Researchers

NATIONAL CANCER INSTITUTE
LABORATORY OF MOLECULAR PHARMACOLOGY
Pommier Y. 1995
The present data suggest that HIV- 1 integrase inhibition may contribute to the antiviral activity of curcumin. These observations suggest new strategies for antiviral drug development that could be based upon curcumin as a lead compound for the development of inhibitors of HIV- 1 integrase. PMID: 7748198- 5 Researchers

NATIONAL CANCER INSTITUTE
CELLULAR DEFENSE AND CARCINOGENESIS SECTION
Yeh GC 1998
These results suggest that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for both the AhR and CYP1A1 (part of an essential detoxification enzyme system).... The chemopreventive effect of curcumin has been variously ascribed to the antioxidant properties of curcumin, inhibition of cyclooxygenase activity, suppression of activator protein- 1- mediated transcription, and induction of apoptosis of tumor cells. Based on our results, curcumin also appears to decrease carcinogen activation. PMID: 9698073- 4 Researchers

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
EXPERIMENTAL THERAPEUTIC BRANCH
George S. Roth. 1999
Thus, our results suggest that DA triggers a death program via oxidative stress- mediated activation of nuclear transcription factors AP- 1 and NF- kB. These apoptotic molecular events may explain the DA- related neurodegenerative processes. 5 Researchers

NATIONAL INSTITUTE ON AGING
MOLECULAR PHYSIOLOGY AND GENETICS SECTION, GERONTOLOGY RESEARCH CENTER
Roth GS. 1999
(Utilizing curcumin studying inflammation factors AP- 1 and NF- kappa B to help determine the mechanisms at play in normal cell metabolism). PMID: 10419543- 5 Researchers

NEW YORK MEDICAL COLLEGE
GRADUATE SCHOOL OF HEALTH SCIENCES
Duvvi, 2001.
Curcumin, a spice widely used in Indian dishes, has anti- carcinogenic and anti- inflammatory properties. It also inhibits the oestrogenic effects of DDT and is synergistic with phytoestrogens. PMID: 11467202- 1 Researcher

NORTH CAROLINA STATE UNIVERSITY
AGRICULTURAL RESEARCH SERVICE, U.S. DEPARTMENT OF AGRICULTURE, AND NORTH CAROLINA AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF FOOD SCIENCE
Fleming HP. 2003
Turmeric was found to almost completely prevent aldehyde formation. PMID: 11052754- 3 Researchers

NORTHWESTERN UNIVERSITY
DEPARTMENT OF PATHOLOGY
M. S.V. Bhide. 1992
This study shows that curcumins inhibit cancer at initiation, promotion and progression stages of development...The results of our anticarcinogenicity studies with curcumins are strengthened by the recent epidemiological finding that dietary intake of turmeric may provide protection against pulmonary cancer among cigarette smokers...Curcumins inhibit the initiation step of carcinogenesis by changing the activity of phase I and phase II carcinogen metabolizing enzymes, thus altering the nature and lowering or removing potent proximate carcinogens that can reach critical intracellular targets. 2 Researchers

PENNSYLVANIA STATE UNIVERSITY COLLEGE OF MEDICINE
DEPARTMENT OF MEDICINE
Kumar R. 1995
These findings demonstrate that curcumin is a potent inhibitor of a growth stimulatory pathway,…and may potentially be useful in developing anti- proliferative strategies to control tumor cell growth. PMID: 7634398- 4 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Conney AH. 1997
(Curcumin was observed to have a strong inhibitory effect on multiple models of tumor formation in animals). PMID: 9054592- 8 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Conney AH. 1997
Combinations of curcumin and RA (vitamin like compound) have a particularly potent inhibitory effect on the proliferation of HL- 60(human leukemia ) calls. PMID: 9112257- 5 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Frenkel K. 1997
(Topical curcumin demonstrated significant antitumor effects against mutiple animal models. Significant activities wer eobserved with all curcuminoids). PMID: 9591190- 3 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1995
(Rutger’s researchers investigated different curcuminoids for their anti- tumor effects and found that I and II were most active). PMID: 7586157- 8 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF BIOLOGICAL SCIENCES
Huang HI. 1995
(In chronic inflammation, signals induce the production of nitric oxide (NO.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. Curcumin and compounds from rosemary and tea inhibit this compound). PMID: 7553604- 3 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF BIOLOGICAL SCIENCES
Chan MM. 1995
Curcumin, contained in the rhizome of the plant Curcuma longa Linn, is a naturally occurring phytochemical that has been used widely in India and Indonesia for the treatment of inflammation. ...(Curcumin was also found to inhibit activation of NF- Kappa B, a pathway which can lead to pathological inflammation and cancer proliferation).  There was more than a thousand- fold difference between the efficacy of curcumin (5uM) and that of NAC (60mM). PMID: 7786295- 1 Researcher 

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1994
These results indicated that not only did curcumin inhibit the number of tumors (colon, forestomach and duodenum) per mouse and the percentage of mice with tumors but it also reduced tumor size. PMID: 7954412- 6 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1992
(Topical application of benzo(A)pyrene (B(a)P), a most potentially carcinogenic compound in smoke, was significantly inhibited by application of curcumin). PMID: 1423891- 5 Researchers

RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1992
This result suggests that dietary curcumin may inhibit AOM (powerful carcinogen)- induced colonic neoplasia in mice. PMID: 1611594- 6 Researchers

STANFORD UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENTS OF SURGERY AND GENETICS
Michael R. Freeman
Previous studies have demonstrated that curcumin (diferuloylmethane), a potent inhibitor of tumor promotion, inhibits AP- 1- mediated transcription. 7 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
Fini ME. 2002
Our findings provide evidence that curcuminoids target the FGF- 2 angiogenic signaling pathway [FGF- 2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis)] and inhibit expression of gelatinase B [an essential component in the process of tumour invations and metastasis]in the angiogenic process. PMID: 10744729- 8 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENTS OF OPHTHALMOLOGY AND ANATOMY AND CELLULAR BIOLOGY
M. Elizabeth Fini. 1999
Curcuminoids, natural products of the Indian spice turmeric, are potent antioxidant and anti- inflammatory agents that have been entered into Phase I clinical trials for chemo- preventation by the National Cancer Institute. At least part of their biological activity can be attributed to their capacity to inhibit activation of AP- 1 and NF- kB transcription factors...To our knowledge, this is the first study showing the efficacy of curcuminoids as implantable drugs for inhibition of angiogenesis locally or as orally active drugs to inhibit angiogenesis systemically...Our findings provide evidence that curcuminoids target the FGF- 2 angiogenic signaling pathway and inhibit expression of gelatinase B in the angiogenic process. 8 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF FAMILY MEDICINE AND COMMUNITY HEALTH
Line PS. 1998
These data suggest that combinations of natural plant compounds (curcumin and isoflavones) may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estrogens. PMID: 9831541- 3 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1997
(Curcumin and other agents may plan an important inhibitory role in the promotion/progression stage of colon carcinogenesis). PMID: 9102217- 5 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
Maheshwari RK. 1999
These results show that curcumin enhanced would repair in diabetic impaired healing, and could be developed as a pharmacological agent in such clinical settings. PMID: 10564565- 8 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PATHOLOGY, BETHESDA
Maheshwari RK. 1998
It may be possible that transforming growth factor- beta1 plays an important role in the enhancement of wound healing by curcumin. PMID: 9776860- 7 Researchers

TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PATHOLOGY
Maheshwari RK. 1996
Since curcumin inhibited the proliferation of HUVEC (a model for testing abnormal cell proliferation), it could turn out to be a very useful compound for the development of novel anti- cancer therapy. PMID: 8913274- 4 Researchers

UNIVERSITY OF ARIZONA
COLLEGE OF PHARMACY
Schneider CD. 2000
(The University of Arizona has received a multi- million dollar U.S. government grant to study turmeric’s anti- inflammatory activities. PMID: 10911509- 2 Researchers

UNIVERSITY OF CALIFORNIA
DEPARTMENTS OF MEDICINE AND NEUROLOGY
Cole GM 2001
Inflammation in Alzheimer’s disease (AD) patients is characterized by increased cytokines and activated microglia... Low and high doses of curcumin significantly lowered oxidized proteins and interleukin- 1beta, a proinflammatory cytokine elevated in the brains of these mice. With low- dose but not high- dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta- amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43- 50%. In view of its efficacy and apparent low toxicity, this Indian spice component shows promise for the prevention of Alzheimer’s disease. PMID: 11606625

UNIVERSITY OF CALIFORNIA SAN DIEGO
DIVISION OF GASTROENTEROLOGY, DEPARTMENT OF MEDICINE
Chauhan DP 2001
These data suggest that a non- toxic concentration of curcumin has a significant effect on the in vitro growth of HT- 29 cells, specifically inhibits COX- 2 expression, and may have value as a safe chemopreventive agent for colon cancer. PMID: 11566484- 3 Researchers

UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE
CHILDREN’S HOSPITAL RESEARCH FOUNDATION
Stanberry LR. 1999
(Curcumin “provided significant protection” in an animal model against herpes simplex virus type 2). PMID: 10443534- 4 Researchers

UNIVERSITY OF FLORIDA
ARGARWAL A. MEDICINE
Nick HS, 2001
HO- 1 occurs as an adaptive and protective response to several inflammatory stimuli…Curcumin has anti- inflammatory antioxidant and renoprotective effects. PMID: 11500326 – 4 Researchers

UNIVERSITY OF IDAHO
DEPARTMENT OF FOOD SCIENCE AND TOXICOLOGY
Hendrix K. 1997
(This group of scientists from the University of Idaho is studying curcumin’s effects on animal immune functions.) PMID: 9049662- 3 Researchers

UNIVERSITY OF ILLINOIS
DEPARTMENT OF FOOD SCIENCE AND HUMAN NUTRITION
Fisher C. 1996
Therefore, curcumin when administered i.p. can act as an effective chemopreventative agent towards DMBA- induced rat mammary tumorigenesis and mammary adduct formation. PMID: 8635149- 4 Researchers

UNIVERSITY OF ILLINOIS AT CHICAGO
THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF PHARMACY
Kim JY 2001
…a novel curcuminoid isolate from turmeric that has been demonstrated to protect neuronal cells from beta- amyloid insult… PMID: 11549465 – 2 Researchers

UNIVERSITY OF ILLINOIS AT CHICAGO
THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF PHARMACY
KIM JK 2001
beta- Amyloids (betaA) induced oxidative stress is a well- established pathway of neauronal cell death in Alzheimer’s disease. From turmeric, Curcuma longa L. (Zingiberaceae), three curcuminoids where found to protect cells from betaA insult…These compounds were better antioxidants than alpha- tocopherol. alpha- Tocopherol did not protect the cells from betaA insult…PMID: 11297823 – 3 Researchers
PZZUTO JM. 1999 (Curcumin and other chemopreventives inhibit skin carcinogenesis in an animal model) PMID: 10615860- 2 Researchers

UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
Chen C. 1999
Curcumin is a potent inhibitor of Epstein- Barr virus cell lines. This effect appears to be mediated through enhanced apoptosis. A further investigation of this effect may be useful in prevention and therapy of B- cell lymphoma in immunodeficient patients. PMID: 10527697- 6 Researchers

UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
BONDADA S. 1999
It has been well known that curcumin is a powerful inhibitor of proliferation of several tumor cells.…NF- kappaB (critical factor in the pathology of inflammation and cancer) binding activity was also downregulated almost completely by curcumin…curcumin caused the growth arrest and apoptosis of lymphoma (cell lines)…PMID: 10527691- 5 Researchers

UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
NAGABHUSHAN M. 1998
Curcumin (Cur) is a phenolic component of common spice, turmeric. We have reported earlier that it possesses antineoplastic and immunosuppressive properties in vitro. PMID: 9733605- 6 Researchers

UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
NAGABHUSKAHN M. 1998
An extract of a common spice (turmeric) is an effective inhibitor of this (an Epstein- Barr virus (EBV) related) process. PMID: 9457037- 5 Researchers

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
DEPARTMENT OF RADIATION ONCOLOGY
You W. 1999
Curcumin has anti- inflammatory, antiproliferative, and antitumor effects. The results suggest that apoptosis (cellular suicide) is involved in the curcumin- induced inhibition of tumor cell growth, and genes associated with cell proliferation and apoptosis may be playing a role in the chemopreventive action of curcumin.…[curcuma longa i.}…is getting the attention of cancer investigators because of its chemopreventive properties against human malignancies. PMID: 1044542- 2 Researchers

UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
DEPARTMENT OF SURGERY
Salahudeen AK. 1998
These findings provide evidence that turmeric and curcumin provide protection against oxidative stress in a renal cell line. PMID: 9436613- 4 Researchers

UNIVERSITY OF MISSOURI- KANSAS CITY
HORMONE RESEARCH LABORATORY, SCHOOL OF DENTISTRY AND MEDICINE
Virji AS. 2000
It is concluded that curcumin is considerably more potent than genistein and quercetin, but cisplatin is five fold more potent than curcumin in inhibition of growth and DNA synthesis…The data presented in this study demonstrate that curcumin compares favorably with cisplatin in its inhibitory effect on both cell growth and DNA synthesis in human oral squamous carcinoma cell line PMID: 10928101- 2 Researchers

UNIVERSITY OF NORTH CAROLINA
DEPARTMENT OF MEDICINE, CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
Sarto RB. 1999
We conclude that curcumin potently inhibits cytokine- mediated NF- kappa B activation (this group has identified a mechanism that this critical factor in cancer and inflammation pathologies is inhibited). PMID: 10477620

UNIVERSITY OF NORTH CAROLINA
DEPARTMENT OF MEDICINE, CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
R. BALFOUR SARTO, 1999.
Nontraditional or alternative medicine is becoming an increasingly attractive approach for the treatment of various inflammatory disorders among patients unresponsive to or unwilling to take standard medications....The use of natural anti- inflammatory products provides an attractive and safe alternative to modulate inflammatory disorders. Curcumin is an anti- inflammatory food product that has been used for centuries in Asian cultures. However, the lack of information regarding a mechanism of action for curcumin combined with unknown effects on mucosal inflammatory gene expression have precluded the widespread clinical use of curcumin in western cultures for treatment of intestinal inflammatory disorders. Our data clearly indicate that cytokine- mediated expression of the adhesion molecule ICAM- 1 and the chemokine IL- 8 in IEC’s is blocked by curcumin treatment...Together, these data provide strong evidence that curcumin blocks IEC gene expression by inhibiting the signal leading to IKK activation, subsequent I- ?Bá phosphorylation/degradation, and NF- ?B activation. This study provides a strong rational to investigate the effect of curcumin in an in vivo experimental model of intestinal inflammation. 7 Researchers

UNIVERSITY OF PITTSBURGH
DEPARTMENT OF PATHOLOGY
Zarnegar R. 2002
(Confirmed that curcumin is an inhibitor of Ap- 1, a protein which can play a pathophysiological role in the proliferation of cancer cells and inflammation). PMID: 10713700- 3 Researchers

UNIVERSITY OF TEXAS
DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY
Ansari GA 2000
Curcumin (diferuloylmethane), a yellow pigment of turmeric with antioxidant properties has been shown to be a cancer preventative in animal studies conducting glutathione research. PMID: 10996298- 8 Researchers

UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
DEPARTMENT OF MOLECULAR BIOLOGY
Rao LV. 2000
We investigated the effect of curcumin, a natural plant phenolic compound known to exhibit anticarcinogenic, antioxidant, and anti- inflammatory properties, on Egr- 1 expression (regulates a number of pathophysiologically relevant genes)…the data show that curcumin suppresses the induction of transcription factor Egr- 1. PMID: 10674404- 2 Researchers

UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
DEPARTMENT OF MEDICAL SPECIALTIES
Rao LV. 2000
Overall, the data suggest that the anticarcinogenic and anti- inflmmatory properties of curcumin may be related to its ability to inhibit cellular gene expression regulated by transcription factors NF- kappa B, AP- 1, and Egr- 1. PMID: 9437186- 3 Researchers

UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF MOLECULAR ONCOLOGY
Aggarwal BB. 1998
Our results demonstrate that the anti- inflammatory properties of curcumin may be attributable, in part, to inhibition of leukocyte (white blood cell) recruitment. (Curcumin was also found to inhibit TNF activated NF- Kappa B, a pathway which can lead to pathological inflammation and cancer proliferation). Curcumin should be explored for its therapeutic value in atherogenesis, bacterial sepsis, inflammation, and tumor metastasis. PMID: 9586949- 4 Researchers

UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF BIOIMMUNOTHERAPY
Aggarwal BB. 1997
Pharacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. Curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (Curcuma longa) that exhibits anticarcinogenic properties in vivo... Overall our results suggest that curcumin is a potent antiproliferative agent for breast tumor cells and may have potential as an anticancer agent. PMID: 9215611- 4 Researchers

UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF MOLECULAR ONCOLOGY
Aggarwal BB. 1995
(Curcumin was also found to inhibit a pathway leading to NF- Kappa B, a cascade which can lead to pathological inflammation and cancer proliferation). PMID: 7559628- 2 Researchers

BHARAT B. AGGARWAL, 1995.
In the present report we demonstrate that curcumin (diferuloylmethane), a known anti- inflammatory and anticarcinogenic agent, is a potent inhibitor of NF- kB activation. 2 Researchers

UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS,
Awashi YC. 2003
…kept on a diet supplemented with only 0.005% (w/w) curcumin had significantly less opacification of lenses… PMID: 10814889 – 6 Researchers

UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF INTERNAL MEDICINE
Awashi YC. 1999
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa) , has been shown to inhibit chemical carinogenesis in animal models and has been shown to be an anti- inflammatory agent. Taken together, these results suggest that GSTs (specific detoxification enzymes) play a major role in detoxification of lipid peroxidation products…and that these enzymes are (positively) modulated by curcumin. PMID: 10514034- 7 Researchers

UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS
Perez- Polo Jr. 1999
(Curcumin is being studied for its positive influence on AP- 1, a protein which can play a pathophysiological role in the proliferation of cancer cells and inflammation). PMID: 10555784- 3 Researchers

UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF INTERNAL MEDICINE, GALVESTON,
Awasthi S. 1998
Our results suggest that induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti- inflammatory and anti- cancer activities of curcumin. PMID: 9675878- 6 Researchers

UNIVERSITY OF TEXAS MEDICAL BRANCH
AWASHI YC.
Curcumin treatment caused a significant induction of the glutathione S- transferase (GST) isozyme (detoxification enzyme)…and these studies suggest that curcumin may be an effective protective agent against cataractogenesis (formation of cataracts) induced by lipid peroxidation (oxidation of fat). PMID: 8901798- 6 Researchers

UNIVERSITY OF TOLEDO
COLLEGE OF ART & SCIENCES
Jankun J. 2001
Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti- cancer drugs used for treatment where lipoxygenases are involved. PMID: 11029517- 4 Researchers

WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF MEDICINE
Majumdar AP. 2001
Curcumin appears to exert its anticarcinogenic properties by inhibiting proliferation and inducing apoptosis in certain gastric and colon cancer cells. PMID: 11396178- 3 Researchers

YALE UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PHARMACOLOGY
Sartorelli AC. 1997
Curcumin, a potent inhibitor of tumor promotion and of tumor cell growth, has also been shown to have antioxidant properties and to inhibit NF- kappa B (NF- Kappa B is a pathway which can lead to pathological inflammation and abnormal cancer proliferation)...Curcumin caused a marked reduction in NF- kappa B activity in nuclear extracts of HL- 60 cells (human leukemia cell line) exposed to this agent… PMID: 9112258- 3 Researchers

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