The most powerful compound in botanical medicine.
The worlds most important herbal extract.

500 milligrams per capsule
Other brands may claim "1000 mg per serving" but hide that the serving size is 3 capsules. Some even claim to have a "500 mg capsule" but the "super complex" is only 300 mg Curcumin and 200 mg Turmeric, which only has about 4% Curcumin. Unfortunately these deceptions are not uncommon in the supplement industry even by the largest vitamin shops; when comparing always check the contents (Curcumin), the concentration (95%) and the amount (500mg) for each capsule, not per serving. Our product contains 500 milligrams per capsule of 95% standardized Curcumin. The suggested serving size is one (1) to four (4) capsules with meals, potentially offsetting the inflammatory response process that occurs during ingestion and digestion. There is absolutely no filler or claimed "enhancing" material to fill the capsule up and lower the Curcumin percentage. Our product contains no sugars or other sweeteners, no starch, no sodium, no soy, no yeast, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no silicon dioxide, no GMO, no artificial colors or flavors, no dyes, no rice powder, no dairy, no gums or any other unnecessary compounds.

200 capsules per bottle
We do not waste the environments resources or your funds by requiring two or more bottles to obtain 200 capsules. Each bottle contains the full 200 capsules.

Are there any side effects or interactions? 
"Curcumin is not toxic to humans up to 8,000 mg/day."
"Patients received 8 g curcumin by mouth daily...No toxicities were observed."
"Curcumin, even in large quantities, does not produce any known side effects in humans."
Turmeric has been used in large quantities as a condiment for thousands of years with no adverse reactions.  The FDA classifies Turmeric as GRAS (General Recognition And Safety). Pregnant women, individuals with gallstones or bleeding disorders, or using chemotherapy or blood thinners should speak with a health care provider before using herbs or dietary supplements in amounts greater than usually found in foods. 

 
Why do Curcumin and Turmeric provide health benefits?
Certain plants manufacture chemicals that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection. In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring this evolution between plants and insects represents an important field of ecological research. Scientists have discovered that many chemicals manufactured in plants and roots not only prevent insect attack but also provide health benefits. Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers. With the advent of sophisticated laboratory testing, biologists are finding that the many indigenous plants and roots from around the world provide medicinal value, and their metabolites are candidates for research. Curcumin’s structure is similar to other plant pigments called polyphenolics (chemicals containing muliple “phenol” groups) which often have potent anti-oxidant and anti-inflammatory properties and associated health benefits. Many similar plant pigments are known as potent antioxidants, for example, the pigments extracted from grapes in red wine ( resveratrol), or in green tea (catechins) or in fruit juices (blueberries, strawberries, pomegranates etc) typically contain polyphenolic antioxidants and have been studied for their possible medicinal or preventive value. Curcumin has been shown to exhibit anti-oxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases such as diabetes, allergies, arthritis, Alzheimer disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered TNF blockers (humira, remicade and enbrel), vascular endothelial cell growth factor blocker (avastin), human epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib), and HER2 blocker (herceptin). Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life". More than 5000 papers published within the past two decades have revealed that curcumin has extraordinary potential in promoting health through modulation of numerous molecular targets.

 
What is the history of Curcumin and Turmeric?
Turmeric is an ancient spice and a traditional remedy. Its health benefits have been described for thousands of years in traditional Indian (Ayruvedic) and Chinese medicine largely because of its proven efficacy in treating conditions with inflammation. These ancient civilizations have vast trial and error experience with many different herbal remedies and food preparations and they selected curcumin as a food additive and major tool for medicinal use based on efficacy. Since 1900 BC numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastro-intestinal systems, aches, pains, wounds  and disorders. Marco Polo, writing of his travels in China, described Turmeric in the 13th century: "There is also a vegetable which has all the properties of the true saffron, as well as the color, and yet it is not really saffron. Turmeric is held in great estimation, and being an ingredient in all their dishes, it bears, on that account, a high price."  The high degree of reverence for Turmeric is established by the fact that it is used in many cultures, each having its own name for the spice: Burmese:fa nwin.  Chinese:wong geung fun, yü chiu.  Danish:gurkemeje.  Dutch:geelwortel.  Finnish:keltajuuri.   French: curcuma, saffron des Indes.  German:gelbwurz, kurkuma.   Icelandic:turmerik.  Italian: curcuma.   Indian:haldee, haridra, haldi, huldee, huldie. Indonesian:kunjit, kunyit.   Japanese:ukon   Malay:kunjit.  Norwegian:gurkemeie,  Polish:klacze kurkumy.  Portuguese:açafrão-da-Índia.   Russian:zholty imbir.  Spanish:azafrán de la India, azafran arabe.   Sinhalese:kaha. Swedish:gurkmeja.  Tamil:munjal.   Thai:ka min.  Vietnamese:bot nghe

Why hasn't the pharmaceutical industry patented Curcumin?
The global pharmaceutical corporations are very interested in owning patents for Curcumin and Turmeric because of the much heralded scientific evidence and the long history of its healing properties. However, that same evidence and history of Turmeric and Curcumin being used medicinally for centuries was the reason the United States Patent and Trademark Office rejected and revoked the patenting rights (Patent No. 5401504) of Turmeric on the grounds that the claims were not new: "USPTO unequivocally rejected all six claims made on August 13, 2001 ruling that Turmeric's medicinal properties were not patentable." As Dr. Bharat B. Aggarwal of the University of Texas MD Anderson Cancer Center in Houston explains: "in the case of Curcumin, a natural compound, no company can reap the benefits if Turmeric shows itself to be an effective anti-cancer drug..." This is unfortunate for pharmaceutical manufacturers who pass promotional and advertising fees to their customers, but good news if you're an educated consumer who doesn't want to pay $20.00 per prescribed pill. Other companies such as "Protandim", "Curamin" and "Juvenon" sell a "patented formula" which contains an undisclosed amount of Turmeric and can cost more than $2.00 per pill.

How does Curcumin work against cancer?
Independent research studies on the anti-cancer properties of turmeric suggests that Curcumin has the potential for treatment of five top cancers in the U.S. -- colon, breast, prostate, lung and skin. Numerous mechanisms have been described for the anticancer activity of Curcumin. Curcumin (diferuloylmethane) is one of the most powerful and promising chemopreventive and anticancer agents, and epidemiological evidence demonstrates that people who incorporate high doses of this spice in their diets have a lower incidence of cancer. How Curcumin exerts its powerful anticancer activities has been thoroughly investigated, and it's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic investigators around the world as a potent anti-carcinogen. Because of low toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology testing and has successively made it through the first stages (Phase I) of clinical testing abroad and is currently in clinical trials at several sites in the U.S.  Inhibition of proliferation of tumor cells, induction of apoptosis (a mode of cell death), inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation have been linked with the anticancer activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules, inflammatory cytokines, chemokines, growth factor receptors, vascular endothelial growth factor (VEGF) and transcription factors by Curcumin have been linked to its antitumor activity. Curcumin also lowers the core inflammatory gene signal, NF-kappaB , resulting in a beneficial domino effect throughout the body. One benefit of this domino effect is a direct reduction in the risk of cancer from overweight-induced inflammation.

How does Curcumin work against arthritis?
Arthritis is also a proinflammatory disease. All current drugs approved for arthritis have anti-inflammatory activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production, block the action of TNF, and have activity against arthritis.

How does Curcumin work against Crohn’s disease (inflammatory bowl disease)?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved for this disease have anti-inflammatory activity. Anti-TNF therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production and the TNF action. Curcumin taken orally has been shown to have activity against Crohn’s disease.

How does Curcumin work against diabetes and overweight-induced disease?
Curcumin acts directly on liver cells to help prevent them from becoming fatty. And it works directly on pancreatic beta cells to help them produce insulin normally. By helping the liver and the pancreas, curcumin is taking stress off the two most important organs whose function declines before the onset of type 2 diabetes. Curcumin also influences key hormones, supports major body organs, and regulates inflammatory signaling all in ways that help correct or prevent metabolic problems. Curcumin helps lower inappropriately high levels of leptin (reducing leptin resistance) while boosting the all-important levels of the adiponectin (which lowers insulin resistance). Curcumin also helps activate the fat-burning gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat cells.Curcumin directly reduces major inflammatory events from occurring inside white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1). By lowering such inflammation, the source of overweight-induced disease is stopped.

How does Curcumin work against psoriasis?
Psoriasis is another proinflammatory disease. Considerable evidence, both in animals and humans, indicates that Curcumin is quite effective against psoriasis.

How does Curcumin work against Alzheimer's disease?
Researchers found that Curcumin not only reduces oxidative damage and inflammation, but also reduces amyloid accumulation and synaptic marker loss and promotes amyloid phagocytosis and clearance. Curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity in vitro, and may help the immune system clear the brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Because Alzheimer's disease is caused in part by amyloid-induced inflammation, Curcumin has been shown to be effective against Alzheimer's. Clinical trials are in progress at UCLA with Curcumin for Alzheimer's.

Recent news and published studies on Curcumin and Turmeric
   January 2012

Cancerous Cells Cannot Thrive Without This

Curcumin: A BIG Medicine Fox News - Chris Kilham - 6 Dec 2010   As relates to turmeric, science has investigated this humble root and has discovered in it a powerful compound called curcumin. This simple material has the ...

Could Curcumin Help Your Liver? LiverSupport.com - Nicole Cutler - 1 Dec 2010   New research demonstrates that a compound in curry could help in the management of chronic liver disease. by Nicole Cutler, L.Ac. Curcumin is found in the ...   Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals Bharat B. Aggarwal, Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern target- Bharat B. Aggarwal and Bokyung Sung  Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail.Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Epub 2008 Dec 26

Coast to Coast AM George Noory Interviews Christian Wilde About Turmeric and Curcumin Coast To Coast AM with George Noory  Researcher Christian Wilde discussed new studies on turmeric, which showed that the spice may reduce the size of a stroke and lower the risk of getting cancer...

Turmeric has been shown to have strong anti-inflammatory properties in the body, and the arteries in particular Coast To Coast AM with George Noory  Author and researcher Christian Wilde reported on alternative approaches to treating heart disease...

Spice Rack...Or Medicine Chest? Nutrition Action Health Letter "Curcumin protects the brain cells in every animal model of traumatic brain injury, whether it's stroke, Alzheimer's disease, Huntington's disease, or mad cow disease," says Gregory Cole, associate director of the Alzheimer's Disease Center at the University of California, Los Angeles. "What's unique about Curcumin," Cole notes, "is that it binds directly to beta-amyloid deposits in the brain and reduces their size." Beta-amyloid is a protein fragment that builds up between brain cells of people with Alzheimer's disease....

Curry Power Science News Magazine "The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," says Bharat Aggarwal, who studies Curcumin at the M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive."

Curcumin at M.D. Anderson Cancer Center The University of Texas, MD Anderson Cancer Center Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis. Epidemiological evidence indicate that incidence of certain cancers is less in people who consume Curcumin than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and anti-inflammatory effects at M. D. Anderson Cancer Center and other medical institutions.

Spice Healer Scientific American Magazine An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases. "A chapter in a forthcoming book, for instance, describes the biologically active components of Turmeric--Curcumin and related compounds called Curcuminoids--as having antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal properties, with potential activity against cancer, diabetes, arthritis, Alzheimer's disease and other chronic maladies. And in 2005 nearly 300 scientific and technical papers referenced Curcumin in the National Library of Medicine's PubMed database, compared with about 100 just five years earlier. Scientists who sometimes jokingly label themselves Curcuminologists are drawn to the compound both because of its many possible valuable effects in the body and its apparent low toxicity. They ponder how the spice or its derivatives might be used, not just as a treatment but as a low-cost preventive medication for some of the most feared ailments. As a treatment, it also has some enticing attributes. Because Curcumin targets so many biological pathways, it could have benefits for cancer therapy: malignant cells may be slow to acquire resistance to it and so might have to go through multiple mutations to avoid the substance's multipronged attack." 1 2 3 4

Previous News and Studies

What is Turmeric-Curcumin.com?
Turmeric-Curcumin.com is the name of our company and website, founded by researchers who believe the best prescription is knowledge. Since the year 2000, our company philosophy has been offering the guaranteed certified highest quality Curcumin, the best customer service, the lowest prices in the industry, and none of the standard marketing hype.  Unlike other suppliers, we do not sell 500 products, or even 5 products; we remain dedicated to the most powerful, healthful and important compound in botanical medicine - Curcumin - concentrated in a 95% powder extract. This extraordinary spice extract has generated such interest that universities and medical centers around the world are continually conducting research studies and discovering new benefits, with at least a dozen clinical trials on humans under way. Due to it's potent antioxidant power, Curcumin has been recognized as one of the most promising food-derived compounds in fighting a variety of degenerative diseases. The scientific evidence remains overwhelming, demonstrating the many health benefits via in vitro, in vivo and human clinical studies and trials. You will receive 100% additive free products; no sugars or other sweeteners, no starch, no sodium, no soy, no yeast, no preservatives, no black pepper extract aka "bioperine" (actually a trademark of the Sabinsa Corporation), no silicon dioxide, no artificial colors or flavors, no dyes, no rice powder, no dairy, no fillers, no gums or any other unnecessary compounds. Please email support@turmeric-curcumin.com or call us with any questions or comments, anytime, and we will respond as quickly as possible: