most powerful compound in botanical medicine,
the worlds most important herbal extract.
What is Turmeric and Curcumin?
Turmeric is a member of
the Curcuma botanical group, which is part of the ginger family of
herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma
longa plant is crushed and powdered into ground Turmeric spice. Ground Turmeric is
used worldwide as a seasoning and is the source
of the extracted Curcumin.
Curcumin is a natural component of the rhizome of Turmeric
and one of the most studied
phytochemicals in science. Turmeric
contains approximately 3% Curcumin, which is extracted until it is 95% pure to
be researched or supplemented.
direct from Turmeric-Curcumin.com, the largest supplier of
supplements at wholesale prices to the general public, research
institutions, physicians, and university medical centers for over
thirteen years. Quality control tests, laboratory analysis
certification, and rigorous
standards all ensure freshness, potency,and purity of content material. Orders are shipped FedEx
or USPS Priority for fast and secure delivery. Contact
for bulk ordering, private
labeling or any other questions. Multiple bottle orders
will receive quantity discounts listed below, 12-bottle case purchases will also
receive free US shipping.
OF Curcumin 95% extract per capsule.
Health-conscious consumers should be careful in selecting a
Curcumin extract product, specifically knowing the difference between Curcumin
and Turmeric. Consumers may be misled by deceptive labels, believing there is
much more true Curcumin extract in a product than there really is. Some examples of these misleading claims make it
difficult to tell how much active Curcumin extract is actually included, because
they are substituting
Turmeric spice powder,
which averages only 3%
Curcumin by weight.
55(2):126-31. Some examples of these deceptions are:
"Doctors Turmeric Curcumin" on the front of the label,
but checking the ingredient finds that each capsule is 100% Turmeric
(curcuma longa), a common and inexpensive spice found in supermarkets and
"500 mg Enhanced Formula"
but only contains 200 mg Curcumin extract, and the remainder is 300 mg Turmeric
"1000 mg Super Complex Curcumin (25%)" which
is actually only 250
mg of Curcumin extract and the
remaining 750 mg is Turmeric spice.
mg per serving" but one serving size is 4 capsules, 250 mg each.
These deceptions are not uncommon in the
supplement industry, even by the largest vitamin shops. The solution is to
compare. Our label clearly
indicates the contents (Curcumin extracted from Turmeric root), the purity
concentration (95%) and the amount (500mg) for each capsule, not per serving.
Our product contains 500 milligrams per capsule of 95% standardized Curcumin
extract. Our extract is standardized to contain a minimum of 95%
Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC),
Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of
76:19:5. Thus, in our
product the full
spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric
(Curcuma longa root) and
represented in their
natural arrangement for maximum potency.
This is the
in clinical trials and medical studies,
free of added chemicals, 'enhancements', or treatments. Unlike
many antioxidants, Curcumin is capable of both preventing free radical
formation, as well as neutralizing existing free radicals, and is considered an
effective bioprotectant due to this dual activity. We supply the purest Curcumin
available, standardized to minimum 95% extract.There is no claimed "enhancing" material to fill
the capsule up and lower the Curcumin
Our product contains no sugars or
other sweeteners, no artificial colors or flavors, no starch, no sodium, no soy,
no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper
extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa
corporation), no GMO, no dyes, no gums.
200 capsules per bottle.
For the environment as well as your finances, we
don't require purchasing two or three bottles to obtain 200 capsules. Each bottle
contains the full 200 capsules, with every 12-bottle case
totaling over two and a half
pounds of pure Curcumin extract. The
suggested serving size is one (1) to four (4) capsules with each meal, preferably with beneficial oils and fats, potentially offsetting the inflammatory response
process that occurs during ingestion and digestion.
Are there any side effects or
interactions related to
Curcumin or Turmeric?
"Curcumin, even in large quantities, does not produce any
known side effects in humans."
Turmeric has been used in
large quantities as a condiment for thousands of years with no adverse reactions.
The US FDA classifies Turmeric as
Recognized As Safe). Pregnant women, individuals with gallstones or using blood
thinners should consult a health care provider before using herbs or dietary
supplements in amounts greater than usually found in foods.
Has the absorption and
bioavailability of Curcumin 95% powder been studied?
Why Turmeric root extract Curcumin may provide health benefits?
Certain plants manufacture chemicals
that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of
organic compounds that deter attackers become more successful, because of their
advanced protection. In nature's never-ending interaction between predator and prey,
insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring
this evolution between plants and insects represents an important field of
ecological research. Scientists have discovered that many phytochemicals manufactured
in plants and roots not only prevent insect attack or fight plant infections, but also provide
human health benefits.
Many cultures create their own botanical pharmacies as
the lore of medicinal plants and remedies is handed down through generations of
healers. With the advent
of sophisticated laboratory testing, biologists are finding that the many
indigenous plants and roots from around the world provide medicinal
value, and their metabolites are candidates for research. Curcumin’s structure is similar to other natural polyphenolics (chemicals containing
multiple "phenol" groups) produced by
plants in response to infectious attack. These natural polyphenols often have potent
anti-oxidant and anti-inflammatory properties as well as immune support health
benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from
blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been
studied for medicinal or preventive value. Curcumin has been
studied for anti-oxidant, anti-inflammatory,
antiviral, antibacterial, antifungal, and anticancer activities, mediated
through the regulation of various transcription factors, growth factors,
inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits
activities similar to recently discovered TNF blockers (humira, remicade and
enbrel), vascular endothelial cell growth factor blocker (avastin), human
epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib),
and HER2 blocker (herceptin). Considering the recent scientific bandwagon that
multi-targeted therapy is better than mono-targeted therapy for most diseases,
Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000
papers published within the past two decades have revealed that Curcumin has
extraordinary potential in promoting health through modulation of numerous molecular
What is the history of Curcumin and Turmeric?
Turmeric is an ancient spice and a traditional remedy. Its health benefits have
been described for thousands of years in
traditional Indian (Ayruvedic) and Chinese medicine largely because of its
proven efficacy in treating conditions with inflammation. These ancient
civilizations have vast trial and error experience with many different herbal
remedies and food preparations and they selected curcumin as a food additive and
major tool for medicinal use based on efficacy.
Since 1900 BC numerous therapeutic
activities have been assigned to Turmeric for a wide variety of diseases and
conditions, including those of the skin, pulmonary, and gastro-intestinal
systems, aches, pains, wounds and disorders. Marco Polo, writing of his travels in China, described
Turmeric in the 13th century: "There
is also a vegetable which has all the properties of the true saffron, as well as
the color, and yet it is not really saffron. Turmeric
is held in great estimation, and being an ingredient in all their dishes, it
bears, on that account, a high price." The high degree of reverence
established by the fact
that it is used in many cultures, each having its own name for the
geung fun, yü chiu. Danish:gurkemeje. Dutch:geelwortel.
Finnish:keltajuuri. French: curcuma, saffron des Indes.
German:gelbwurz, kurkuma. Icelandic:turmerik.
Indian:haldee, haridra, haldi, huldee, huldie.
Indonesian:kunjit, kunyit. Japanese:ukon circumin Malay:kunjit.
kurkumy. Portuguese:açafrão-da-Índia. Russian:zholty
imbir. Spanish:azafrán de la
India, azafran arabe. Sinhalese:kaha. Swedish:gurkmeja.
Tamil:munjal. Thai:ka min. Vietnamese:bot
the pharmaceutical industry patented Curcumin?
on Curcumin and Cancer. Independent research studies on suggest that Curcumin has the potential for
treatment of cancers including colon, breast, prostate, lung, skin and bowel. Curcumin is one of the most powerful and promising chemopreventive and
anticancer agents, and epidemiological evidence demonstrates that people who
incorporate high doses of this spice in their diets have a lower incidence of
cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic
investigators around the world. Because of low
toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology
testing and has successively made it through the first stages (Phase I) of
clinical testing abroad and is currently in clinical trials at several sites in
the U.S. Numerous mechanisms have been
described for the anticancer activity of Curcumin. >Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin
has “enormous” potential to prevent and treat cancer. Curcumin was able to
suppress tumor formation, growth, and even metastasis according to their review.
Currently, there are clinical trials being conducted on the effects of Curcumin
on patients with bowel cancer. Inhibition of proliferation
of tumor cells, induction of apoptosis (a mode of cell death), inhibition of
transformation of cells from normal to tumor, inhibition of invasion and
metastasis and suppression of inflammation have been linked with the
activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules,
inflammatory cytokines, chemokines, growth factor receptors, vascular
endothelial growth factor (VEGF) and transcription factors by Curcumin have been
linked to its antitumor activity. Curcumin also has been studied with
the core inflammatory gene signal, NF-kappaB,resulting in a beneficial domino effect throughout the body. One benefit of this
domino effect is a direct reduction in the risk of cancer from
How may Curcumin work against
Arthritis is also a proinflammatory
disease. All current drugs approved for arthritis have anti-inflammatory
activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this
disease. Curcumin has been shown to both suppress the TNF production, block
the action of TNF, and have
activity against arthritis.
When inflammation is reduced, the added benefit is
pain relief. A double-blind, crossover study showed that Curcumin may be effective
in relieving pain and improvements in morning stiffness, walking time, and joint
How may Curcumin work against
Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved
for this disease have anti-inflammatory activity. Anti-TNF therapy has been
approved for this disease. Curcumin has been shown to both suppress the TNF
production and the TNF action. Curcumin taken orally has been shown to have
activity against inflammatory bowel disease. Study results
suggest that Curcumin could have a protective role in ulcerative colitis via
regulation of oxidant/anti-oxidant balance and modulation of the release of some
inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced
colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK
signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and
the nitrite production in colonic mucosa, reducing the development of chronic
experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative
How may Curcumin work against
Curcumin acts directly on liver cells to help
prevent them from becoming fatty, and studies have concluded that Curcumin may
have an anti-diabetic effect by decreasing serum fatty acid through the
promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells
to help them produce insulin normally. By helping the liver and the pancreas,
Curcumin is taking stress off the two most important organs whose function
declines before the onset of type 2 diabetes. Curcumin also influences key
hormones, supports major body organs, and regulates inflammatory signaling all
in ways that help correct or prevent metabolic problems. Curcumin helps lower
inappropriately high levels of leptin (reducing leptin resistance) while
boosting the all-important levels of the adiponectin
(which lowers insulin resistance). Curcumin also helps activate the fat-burning
gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat
cells. Curcumin directly reduces major inflammatory events from occurring inside
white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte
chemotactic protein-1). By lowering such inflammation, the source of
overweight-induced disease is targeted.
How may Curcumin work against obesity AND metabolic syndrome?
In the prevention and treatment of obesity and metabolic
syndrome, Curcumin has been reported to modulate numerous targets that have been
linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues.
2) Curcumin can suppress NF-κB activation induced
by a wide variety of inflammatory agents through inhibition of degradation of
IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation
of NF-κB, and this leads to the suppression of expression of inflammatory
biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth
factor. 4) Curcumin has been shown to downregulate the expression of
various NF-κB-regulated proinflammatory adipocytokines including chemokines
(such as MCP-1, MCP-4, and eotaxin) (199)
and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression
of plasminogen activator inhibitor type-1 through the inhibition of the
transcription factor early growth response (Egr)-1 gene product that has been
closely linked with insulin resistance and obesity. 5) Curcumin has been reported
to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate
cells. 6) Curcumin has been shown to downregulate activation of
c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin
pathway, which is closely linked to obesity. Later studies have indicated that
Curcumin inhibits Wnt pathway signaling through downregulation of the
transcription coactivator p300. Another potential mechanism by which Curcumin
could inhibit β-catenin signaling is through inhibition of glycogen synthase
kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin.
Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32).
8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1
through the activation of Nrf2 in pancreatic cells and thus mediate the survival
of these cells. 9) Curcumin downregulates the secretion of insulin-like growth
factor-1 but induces the expression of insulin-like growth factor binding
protein-3. 10) Curcumin interrupts leptin signaling
by reducing phosphorylation levels of the leptin receptor (Ob-R) and its
downstream targets. 11) Curcumin suppresses gene expression of Ob-R in
HSCs. 12) Curcumin has been reported to increase the expression of
adiponectin, which negatively controls obesity.
How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory
disease. Considerable evidence, both in animals and humans, indicates that Curcumin
may be effective against psoriasis.
How may Curcumin work against Alzheimer's
Researchers found that Curcumin
not only reduces oxidative damage and inflammation, but also
reduces amyloid accumulation and synaptic marker loss and promotes amyloid
phagocytosis and clearance. Curcumin worked to prevent synaptic marker and
cognitive deficits caused by amyloid peptide infusion and abeta oligomer
toxicity in vitro, and may help the immune system clear the
brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin
for Alzheimer's. In the
Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that
reducing inflammation has positive effects on patients with Alzheimer’s.
Curcumin significantly lowered several inflammation markers, in addition to
reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent.
How may Curcumin work
as an Anti-inflammatory?
Turmeric is safe and non-toxic and
has been studied for anti-inflammatory properties, inhibiting various molecules that
contribute to inflammation such as lipooxygenase, COX-2, leukotrienes,
prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis
factor (TNF), and interleukin-12 (IL-12). One study compared the
effectiveness of Curcumin – the active ingredient in turmeric – and a popular
non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end
of the six days, those taking the Curcumin and the NSAID enjoyed a significantly
better anti-inflammatory response than placebo. The spice worked as well as the
drug, but without the negative side effects.
Recent news and published studies on Curcumin and Turmeric
Can Kill Cancer Cells
Care2.com October 2014
In cancer cells, curcumin, the pigment in the spice turmeric that makes curry
powder yellow, upregulates and activates death receptors (as shown in human
kidney cancer cells, skin cancer cells, and nose and throat cancer cells).
Curcumin can also activate the death machine directly (as shown in lung cancer
and colon cancer). Caspases are so-called “executioner enzymes,” that when
activated, destroy the cancer cell from within by chopping up proteins left and
right—kind of like death by a thousand cuts. And that’s just one pathway.
Curcumin can also affect apoptosis in a myriad other ways, affecting a multitude
of different types of cancer cells. It also tends to leave normal cells alone
for reasons that are not fully understood. Overall, researchers “showed that
curcumin can kill a wide variety of tumor cell types through diverse mechanisms.
And because curcumin can affect numerous mechanisms of cell death at the same
time, it’s possible that cancer cells may not easily develop resistance to
curcumin-induced cell death like they do to most chemotherapy.”
extract can have the potential to boost brain stem cells
TheRawFoodWorld,com October 2014
Curcumin is one of the ingredients in turmeric that exhibits over 150
potentially therapeutic activities and researchers have found it to play a
significant role in improving Parkinson’s, Alzheimer’s, and stroke damage...Dr.
William LaValley is one of the leading natural medicine cancer physicians. He
actually devoted his time in researching the science of curcumin, which has the
most evidence-based literature supporting its use against cancer of any other
nutrient. He explained, “The curcumin molecule may cause either an increase in
activity of a particular molecular target, or a decrease/inhibition of activity.
Either way, studies repeatedly show that the end result is a potent anti-cancer
MyDigitalFC.com October 2014
Curcumin is the colouring principle of turmeric — it is the element that gives
the herb its yellow hue. Aside from being the most important component of
turmeric, curcumin is responsible for the herb’s anti-inflammatory effects.
Research suggests that curcumin, like cayenne, another medicinal spice found in
chillies, depletes substance P, the pain receptor and neurotransmitter, in the
nerve endings (nociceptors). Research also suggests that curcumin and related
compounds suppress pain through a mechanism similar to conventional coxib-2
inhibitors — the ‘new’ class of non-steroidal anti-inflammatory drugs (NSAIDs)...Laboratory
and animal studies suggest that curcumin has the potential to prevent and treat
various forms of cancer: colon, prostate, breast, and skin. As a matter of fact,
there has been a substantial amount of research on turmeric’s anti-cancer
potential and the results are promising. In one clinical study, researchers
examined the pain-relieving properties of curcumin and/or whether it could
suppress coxib-2 expression in human colon cancer cells. After exposing colon
cancer cells to curcumin, they found the compound not only subdued cell growth,
but also downgraded the expression of coxib-2 on the basis of a time- and
dose-formatted chart. In addition, researchers observed that curcumin appeared
to be a safe, natural coxib-2 inhibitor in human patients.
Blocking Effects of Turmeric
Care2.com October 2014
Curcumin, present in the Indian spice turmeric, which is used in curry
powder, is one such agent that is currently under clinical investigation for
cancer chemoprevention.” According to their mode of action, chemopreventive
agents are classified into different subgroups: antiproliferatives,
antioxidants, or carcinogen-blockers. Curcumin belongs to all three, given its
multiple mechanisms of action. Curcumin appears to play a role helping to block
every stage of cancer transformation, proliferation, and invasion, and may even
help before carcinogens even get to our cells. A study back in 1987 investigated
the effects of curcumin on the mutagenicity (DNA mutating ability) of several
toxins and found that curcumin was an effective antimutagen against several
environmental and standard mutagenic and cancer-causing substance.
inhibits breast cancer stem cell migration.
Stem Cell Research Therapy October 2014
Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown
to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the
aggravated migration potential of breast CSCs (bCSCs), and (ii) the effects of
curcumin in modulating the same...Cumulatively, our findings disclose that
curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative
Benefits Of Turmeric
Huffingtonpost.com October 2014
Curcumin, the compound in turmeric responsible for that bright hue, is behind a
whole host of the health benefits attributed to the spice. A 2012 study examined
one perk of curcumin in particular: the ability of the extract to prevent heart
attacks among bypass patients. The study followed 121 patients who had bypass
surgery between 2009 and 2011. Three days before surgery through five days
after, half of the patients took curcumin capsules, while the other half took
placebo pills. During their post-bypass hospital stays, more people in the
placebo group experienced a heart attack (30 percent) compared with those in the
curcumin group (13 percent), Reuters reported. While not a substitute for
medication, the researchers pointed out, the antioxidant and anti-inflammatory
properties of curcumin may contribute to as much as a 65 percent lower chance of
heart attack among bypass patients. ... Among people with prediabetes, curcumin
capsules were found to delay the onset of Type 2 diabetes in a 2012 study. Over
nine months, study participants were given either curcumin supplements or
placebo capsules. Just over 16 percent of people taking the placebo pill were
diagnosed with Type 2 diabetes by the end of the study, while no one taking
curcumin was. Again, researchers chalk these results up to the anti-inflammatory
and antioxidant powers of the compound. ... While studies in humans are still in
very early stages, lab and animal studies have shown promising effects of
curcumin in the fight against cancer. Curcumin "interferes with several
important molecular pathways involved in cancer development, growth and spread,"
according to the American Cancer Society, even killing cancer cells in the lab
setting and shrinking tumors and boosting the effects of chemotherapy in
enhances mood in depression research trial
Medicalxpress.com October 2014
Curcumin was significantly more effective than the placebo in improving several
mood-related symptoms in the volunteers. The compound had an even greater
efficacy in a small subgroup of individuals with atypical depression, which can
be characterised by significant weight gain or increased appetite and
hypersomnia. "In animal-based studies curcumin has been consistently shown to
have antidepressant effects and it has been hypothesised that curcumin would
have antidepressant effects in people with major depression," said Dr Lopresti,
who is a clinical psychologist in a private practice. "There have been a few
positive human-based studies investigating the effects of curcumin in
depression. However, this is the first randomised, double blind,
placebo-controlled study and over the longest duration.
Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
Yumanewsnow.com October 2014
The researchers treated human colon cancer tumor cells with curcumin. "We
discovered that curcumin turns off the active form of cortactin," said
Radhakrishnan, who led the experiments in the lab. "Thus, when cortactin is
turned off, cancer cells lose the ability to move and can't metastasize to other
parts of the body." More specifically, curcumin "turned off" cortactin by
interacting with, and activating, an enzyme known as PTPN1. This enzyme acts as
a phosphatase to remove phosphate groups from cortactin – a process known as "dephosphorylation."
"This effect, essentially known as 'dephosphorylating cortactin' correlated with
reduced ability of colon cancer cells to migrate," Kiela said. "This suggests
that curcumin reduces cancer cells' ability to migrate, meaning the cancer can't
restores sensitivity to retinoic acid in triple negative breast cancer cells
Biomedcentral.com October 2014
Curcumin suppresses the expression level of FABP5 and PPARβ/δ in triple
negative mammary carcinoma cells. By targeting the FABP5/PPARβ/δ pathway,
curcumin prevents the delivery of retinoic acid to PPARβ/δ and suppresses
retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that
suppression of the FABP5/ PPARβ/δ pathway by curcumin sensitizes retinoic acid
resistant triple negative breast cancer cells to retinoic acid mediated growth
curcumin may protect gut function
Healthcanal.com October 2014
Oral curcumin may be a viable therapy to improve intestinal barrier function
changes caused by consuming a high-fat Western diet, according to a preclinical
study by Virginia Commonwealth University School of Medicine researchers.
fights Alzheimer's disease
Foodconsumer.org October 2014
A study led by scientists at Beijing University of Chinese Medicine in Beijing,
China suggests taking curcumin supplements may help prevent Alzheimer’s
disease...Curcumin is an important supplement that may be used to prevent or
treat cancer, inflammatory diseases, cystic fibrosis, and diabetes mellitus and
many other diseases in addition to Alzheimer's disease.
promotes turmeric as promising anti-cancer agent
GroundReport.com October 2014
Curcumin could provide an alternate means to the prevention of cancer. The
effect of curcumin as an antioxidant, antibacterial agent and anti-tumor agent
are well documented and it also has a therapeutic or preventive effect on
several other diseases. The study looks at the chemopreventive effects of
curcumin in cancer-prevention with specific focus on curcumin’s effect on the
regulation of cell signaling and genetic pathways. Further, the study notes that
turmeric and curcumin show no significant toxicity at all.
Living with Ruth Holmes: Ancient herb used as treatment
Stroud News and Journal September 2014
The bright yellow pigment contains the active compound curcumin, which is found
in the roots of certain tropical plants like turmeric, and has powerful
anti-inflammatory actions. Just like the non steroidal anti inflammatory
medications, it blocks the formation of the pro-inflammatory prostaglandins, and
leukotrienes (also inflammatory) but does not have the side effects on the
stomach that the anti-inflammatory would. as an anti-inflammatory effect on the
stomach. Curcumin is highly recommended in osteoarthritis and rheumatoid
arthritis as well as post operative inflammation. Curcumin can also be used as
a poultice for inflammatory skin conditions like psoriasis and eczema, this herb
will not treat any pain, as its action is to reduce and prevent further
inflammation from occurring which is what causes the discomfort in the first
The Asian Spice, Helps Fight Mesothelioma
Medicaldaily.com September 2014
Curcumin, has long been known for its cancer-inhibiting properties. But when
it's combined with cancer-destroying peptides (bonded chains of amino acids),
the resulting molecule promotes growth of a protein inhibitor known to combat
the progression of mesothelioma.
Spice May Help Slow Mesothelioma Growth
Survivingmesothelioma.com September 2014
Yet another study has demonstrated the potential mesothelioma-fighting
properties of curcumin, an anti-inflammatory polyphenol that is the primary
component in the spice turmeric. The latest study suggests that applying
curcumin along with cancer-fighting peptides may increase the levels of a
protein inhibitor that can slow the progression of mesothelioma.
restores sensitivity to retinoic acid in triple negative breast cancer cells
BMC Cancer September 2014
Treatment of retinoic acid resistant triple negative breast cancer cells with
curcumin sensitized these cells to retinoic acid mediated growth suppression, as
well as suppressed incorporation of BrdU. Further studies demonstrated that
curcumin showed a marked reduction in the expression level of FABP5 and PPARbeta/delta.
We provide evidence that curcumin suppresses p65, a transcription factor known
to regulate FABP5.
Theage.com.au August 2014 Turmeric, with its active ingredient curcumin,
are "blockbuster nutrients", according to professor Marc Cohen, head of
Complementary Medicines at RMIT. "Turmeric is a powerful antioxidant which stops
lipid oxidation and is anti-inflammatory," says Cohen, who devoted an entire
chapter to turmeric in his book, Herbs and Natural Supplements: An
Evidence-Based Guide. "It is a possible aid in preventing chronic
degenerative diseases like Alzheimer's disease."
the treatment of major depression: a randomised, double-blind, placebo
Newindianexpress.com August 2014
Curcumin, the principal curcuminoid derived from turmeric influences several
biological mechanisms associated with major depression, namely those associated
with monoaminergic activity, immune-inflammatory and oxidative and nitrosative
stress pathways, hypothalamus-pituitary-adrenal axis activity and
neuroprogression, the study said. It is effective for the treatment of
depressive symptoms in individuals with major depressive disorder. Curcumin is
the substance in turmeric which gives the yellow color.
Eat to Beat
aarp.org August 2014
Laboratory studies have found that curcumin—the main ingredient in the spice
turmeric, which gives curry its characteristic yellow color and sizzle—can fight
against cancerous changes in healthy cells as well as slow the growth of
malignant cells. Some evidence suggests that curcumin may also offer protection
against brain tumors.
Cltampa.com August 2014
With more than 50 healing properties, modern research has found that the
effectiveness of turmeric stems from curcumin, a natural compound it contains
that is rich in antioxidants and anti-inflammatory ability. Thousands of animal
and human studies have been conducted on turmeric and curcumin as both a
preventive and curative agent. Current research targets curcumin’s efficacy in
treating some of the world’s biggest health threats including cancer, heart
disease, type 2 diabetes and Alzheimer’s disease.A number of curcumin studies
have shown promising results. Curcumin can kill cancer cells in laboratory
dishes and also slows the growth of the surviving cells. Curcumin has been found
to reduce development of several forms of cancer in lab animals and to shrink
animal tumors. On the U.S. National Library of Medicine’s website,
2,840 abstracts are listed about the study and benefits of turmeric and
Mechanism of curcumin resistance to human cytomegalovirus in HELF cells
BMC Complementary and Alternative Medicine August 2014
Curcumin anti-HCMV effect may possibly be that curcumin concurrently alters
host cell microenviroment and inhibits the HCMV antigen expressions. These
findings may provide a basic understanding of the curcumin anti-HCMV effect
and a novel strategy for further development of curcumin anti-HCMV
the one cooking trick for weight loss success?
Nola.com July 2014
Turmeric, the yellow ground spice you find in curry power, is a superspice
when it comes to health and weight loss because of its active compound
called curcumin. Hundreds of studies have been completed on its
effectiveness against cancer, skin ailments, and lung health, just to name
of few. But when it comes to the battle of the bulge, turmeric extract
suppressed fat tissue growth in rodent models.
Turmeric branded latest superfood to protect against
Business-Standard.com July 2014
Since inflammation is a major
factor in the development of most chronic degenerative diseases including
cardiovascular disease, allergies, type 2 diabetes and Alzheimer's disease,
curcumin's anti-inflammatory power holds great promise in all of these
conditions and many more. Murray said that the antioxidant activity of
curcumin is superior to antioxidant nutrients like vitamin C and E, as they
are effective against only water and fat-soluble pro-oxidants. Curcumin also
helps in preventing LDL cholesterol - one of the worst kind of cholesterol -
from getting oxidised and damaging arteries. and evidence is gaining that
curcumin could also slow down ageing and prevent age-related diseases.
palmbeachillustrated.com July 2014
Curcumin: An active ingredient in turmeric, this antioxidant has shown
anti-cancer effects in laboratory studies and is anti-inflammatory.
Turmeric, Curcumin fights Alzheimer's disease
Foodconsumer.org July 2014
Curcumin one of the active ingredients found in turmeric has been known to
protect against cancer, Alzheimer's disease, type 2 diabetes mellitus,
allergies, arthritis and other chronic diseases. Epidemiological studies
show that incidence of Alzheimer's disease in Southeast Asia where turmeric
is commonly consumed as a spice was 4.4 times lower, compared to that found
in countries where the price is not as commonly used.
modulation of high fat diet-induced atherosclerosis and steatohepatosis in
LDL receptor deficient mice
Sciencedirect.com July 2014
Curcumin also reduced body weight gain and body fat without affecting fat
distribution...However, at a high dose, curcumin suppressed development of
steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in
liver. Conclusion Curcumin through a series of complex mechanisms,
alleviated the adverse effects of high fat diet on weight gain, fatty liver
development, dyslipidemia, expression of inflammatory cytokines and
atherosclerosis in Ldlr−/− mouse model of human atherosclerosis.
to keep in your medicine cabinet
FoxNews.com July 2014
Curcumin, the active compound in turmeric, is what makes this spice so
special and turmeric happens to be one of the only readily available, edible
forms of it. A 2007 study also showed curcumin to have anticancer
properties, with the potential to fight malignant diseases, diabetes,
allergies, arthritis and Alzheimer’s disease.
Antibiotic Properties Naturally Found in the Kitchen
Globalnews.com July 2014
Curcumin. Turmeric can boost immunity, helps to maintain cholesterol levels,
and can even slow the process of aging. Researchers from the University of
Texas M. D. Anderson Cancer Center have attested to the benefits.
disease-prevention benefits of Indian spices
FoxNews June 2014
Curcumin, derived from a plant that is native to the tropical southeastern
Indian state of Tamil Nadu, also is used "as an adjuvant in chemotherapy,
especially in breast, colon, head and neck cancer and in leukemia. Some
components of curcumin are clinically shown to prevent the formation of
prostate, skin and pancreas cancer cells and brain tumors.
Five Tips To Relieve Joint Pain
SMmirror.com June 2014
Curcumin, is a compound known to interfere with the chemicals that cause
inflammation. Multiple clinical studies have associated curcumin with
anti-inflammatory and antioxidant properties. In one study, two grams of
curcumin extract provided to subjects was found to provide pain relief that was
equivalent to ibuprofen for pain associated with osteoarthritis of the knee.
How What You Eat Can Help the Spinal Cord Heal Itself Valpolife.com
DHA and curcumin appear to invoke several molecular mechanisms that preserved
neurological function in the rats. This is an exciting first step toward
understanding the role that diet plays in protecting the body from degenerative
Why is there Turmeric in my cereal?
BangorDailyNews.com June 2014
Curcumin is actually an antioxidant that has been shown to inhibit cancer cells
in the laboratory, and curcumin slows the growth and spread of some cancers in
some animal studies. Clinical trials are underway to see how it will benefit
humans. Curcumin is being studied for its possible benefit for arthritis,
Alzheimer’s disease and stomach ulcers as well as lowering bad cholesterol.
Curcumin has the ability to modulate genetic activity and expression—both by
destroying cancer cells and by promoting healthy cell function. It also promotes
anti-angiogenesis, meaning it helps prevent the development of additional blood
supply necessary for cancer cell growth. As for its effect on molecular
pathways, curcumin can affect more than 100 of them, once it gets into the cell.
IrishNews.com May 2014
Curcumin, the active ingredient in turmeric. This has been found to have
anti-allergy properties, which inhibit the release of histamine. Commonly used
in Middle Eastern and Asian cuisine as the spice turmeric, curcumin is a
phytochemical with powerful antioxidant and anti-inflammatory actions that are
comparable to steroidal and nonsteroidal drugs.
Protective effect of curcumin against heavy metals-induced liver damage
Curcumin protects against the hepatotoxicity induced by heavy metals. • Curcumin
scavenges free radicals induced by heavy metals in liver. • Curcumin’s
hepatoprotective effect involves the heavy metals chelation. • Curcumin promotes
liver protection by upregulating the Nrf2/Keap1/ARE pathway. • Curcumin
analogues or formulations improve hepatoprotection against heavy metals.
Hidden Secrets of an Ancient Spice
Huffingtonpost.com May 2014
Curcumin could provide antidepressant effects. Research on turmeric and diabetes
also looks promising. Scientists have demonstrated that turmeric in the diet may
be helpful in decreasing blood sugar. Traditional health uses of turmeric in
India are to help wound healing and gastrointestinal symptoms. Now researchers
from The University of Nottingham and Ludwig Maximilians University in Munich
have found that curcumin may help reduce inflammation associated with tendinitis.
Both turmeric and curcumin have shown potential to prevent DNA damage and help
DNA repair. That is good news for preventing disease and slowing the aging
reverse age associated cerebrovascular dysfunction
examiner.com April 2014 Curcumin is an antioxidant present in high
amounts in turmeric which is the active ingredient that appears to provide
turmeric with a number of potential healing abilities. A new study which has
been published in the journal Cellular Physiology and Biochemistry has indicated
that turmeric might provide therapeutic benefits for reversing age-related
cerebrovascular dysfunction. In cerebrovascular dysfunction blood flow and
circulation to the brain is impacted.
inhibit cancer causing cells
TheHindu.com April 2014
The active ingredient in turmeric is curcumin and since second millennium BC, it
is widely used in Asian medicine, food and cosmetics. In fact, medicinal uses of
turmeric are well documented in folk medicine, Ayurveda and traditional Chinese
and oriental medicine. It’s a fact that curcumin is therapeutic and helps in
treating respiratory conditions like asthma, liver disorders, anorexia, diabetic
wounds etc. It is anti-septic, anti-oxidant and anti-carcinogenic and that’s why
there is a lot of interest on turmeric.Research has proved that due to curcumin
there is low incidence of colon cancer and neuro-degenerative disorders such as
Parkinson’s in Asians. Research has proved that curcumin can inhibit cancer
causing cells or genes. The challenge now lies in delivering the right amount of
curcumin to the cancer cells.
Boost your health one cup at a time
TampaBay.com April 2014
Today, turmeric/curcumin research is focused on its effectiveness in fighting
cancer cell growth. Breast cancer research using stem cells has shown that
curcumin inhibits malignant cell formation. A study in the Asia Journal of
Clinical Nutrition reported that turmeric/curcumin can protect the gallbladder
and promote bile flow during detoxification from drugs, pesticides and other
toxins. Curcumin and a cruciferous vegetable (cauliflower, broccoli, Brussels
sprouts) make an excellent combination for removal of mercury, lead and plastic
reveals that turmeric may be beneficial in many health conditions, with its
magic ingredient, curcumin
Dawn.com April 2014
‘The Golden Wonder Herb’ is much more than that: It is a natural antiseptic and
antibacterial agent, useful in disinfecting cuts and burns. Is a natural liver
detoxifier. May prevent and slow the progression of Alzheimer’s disease by
removing amyloyd plaque build-up in the brain. Is a potent natural
anti-inflammatory that works as well as many anti-inflammatory drugs but without
the side effects; it is a natural treatment for arthritis and rheumatoid
arthritis. Is a natural painkiller and cox-2 inhibitor. May aid in fat
metabolism and help in weight management. Has long been used in Chinese medicine
as a treatment for depression. Speeds up wound healing and assists in
remodelling of damaged skin. May help in the treatment of psoriasis and other
inflammatory skin conditions.
Inhibits Prostate Cancer Bone Metastasis
Journal of Cancer Therapy April 2014
A number of studies have focused on the beneficial properties of Curcumin (diferuloyl
methane, used in South Asian cuisine and traditional medicine) such as the
chemoprevention of cancer. Recent studies have also indicated that this material
has significant benefits for the treatment of cancer and is currently undergoing
several clinical trials.
Ocala.com March 2014
Curcumin, one of the active compounds in turmeric spice, popular in Indian
cuisine. Many studies prove curcumin slows down the growth of different types of
cancer. Curcumin may be helpful for pancreatitis because it reduces inflammation
in the pancreas and reduces inflammatory pain-causing chemicals. Wonderful, but
you may need special IVs or supplements to get it to work.
CapeGazette.com March 2014
In animal studies, turmeric’s bright yellow pigment, curcumin, has been
effective in preventing tumor formation. Observational studies in populations
that consume large amounts of curry have strongly suggested that curcumin may
help prevent cancer in the lower intestine.
Paktribune.com March 2014
Curcumin, an active ingredient of turmeric, can fight colon cancer when used in
combination with a popular anti-inflammatory drug, say researchers...Curcumin
increases the anti-cancer and anti-inflammatory effects of Celecoxib while
reducing its dose, thus reducing its toxic side-effects, including the rate of
heart attack and stroke.
WonderWoman.in March 2014
"We studied the effects of curcumin on patients with major depressive disorder,"
says study author Ajay Goel, PhD, director of epigenetics and cancer prevention
at Baylor University Medical Center. "It's possible it may help alleviate
short-term mood issues, too." Curcumin inhibits the production of monoamine
oxidase, an enzyme that at high levels is linked to depression.
GuardianLV.com March 2014
Over a series of six months the study revealed the involvement of turmeric
extract, curcumin does stop the fatty deposits forming on the inner surfaces of
the arteries obstructing the blood flow...The trials results in curcumin being
used without any serious unwanted effects and revealed lasting benefits for
diabetes patients. Turmeric is well-known for its liver healing properties
Curcumin is the active ingredient that gives turmeric its orange-yellow color.
Along with related chemicals, it comprises the extraction of curcuminoid.
CharismaNews.com March 2014
“Turmeric contains curcumin, which can inhibit the growth of cancer cells,” she
says. “It reduces inflammation. It supports your immune system, it’s great for
your liver function, and, as you know, it’s used in Indian cooking.”
Ocala.com March 2014
Put curcumin, the active ingredient of the common spice, turmeric, at the top of
your list of Alzheimer's preventives. Seriously. Researchers have published
1,000 scientific studies on the antioxidant and anti-inflammatory properties of
curcumin. A recent Japanese study showed symptom improvement for those who
supplemented with turmeric capsules for one year. Two participants who had
severe cases were even able to recognize family members by the study's
conclusion. Back in 2008, researchers in India published a paper reviewing the
major research done on curcumin as a treatment for Alzheimer's. They noted that
curcumin apparently has the ability to help a component of the immune system
(macrophages) clear away amyloid plaques from the brain. They concluded, “…based
on the main findings above, curcumin will lead to a promising treatment for
NewsTrackIndia.com March 2014
Curcumin, a spice used in the preparation of tumeric powder, reduced the size of
tumours in mice by a third while slowing the reproduction rate of rogue cells,
the Daily Express reported.
News.am February 2014
A study at Baylor University found that curcumin, the main compound in the spice
turmeric, worked as well as the popular antidepressant Prozac. Study
participants were divided into three groups: one took 500 milligrams of curcumin
twice a day; the second took a standard dose of Prozac, and the third group took
a combination of both. After six weeks, curcumin relieved symptoms of depression
as effectively as Prozac.
Atlantablackstar.com February 2014
Curcumin is a natural carotenoid and polyphenol which may be isolated from
Curcuma longa or turmeric, a rhizome. Owing to their structure, carotenoids are
scavengers of free radicals, which make them great anti-oxidants and boosters of
the immune system of vertebrates, humans included. Curcumin is also an effective
antibacterial agent and anti-carcinogenic. Studies have demonstrated that
curcumin inhibits the growth of a number of tumors when used in combination with
radiation therapy. In prostate cancer, curcumin overcomes the effect of
prosurvival gene expression induced by the exposure of cancer cells to
WorldBulletin.com February 2014
The curcumin diet significantly reduced bile duct blockage and curbed liver cell
damage and scarring by interfering with chemical signalling pathways involved in
Cancer Prev Res (Phila).
Curcumin, the primary component in the dietary spice turmeric, may be a powerful
ally in the
fight against malignant mesothelioma. The new study, published in the
journal Cancer Prevention Research, finds that curcumin may both attack existing
mesothelioma cells and protect against the development of new ones. Curcumin is
a polyphenol with anti-inflammatory properties. Numerous studies have confirmed
its ability to help fight cancer, including mesothelioma. In the newest study, a
team at the University of Vermont tested curcumin on
human mesothelioma cell lines as well as cells derived from infected mice.
TwoCircles.net January 2014
Curcumin has been shown to be particularly beneficial in this aspect. "These
phytochemicals showed their efficiency to counter DNA damage caused by arsenic.
This DNA damage initiates the process of cancer development; therefore reduction
of such damage may pave a way to cancer prevention. Apart from this,
phytochemicals also play a role in repair of DNA damage. We conducted a field
study where curcumin has been found to be of great value in combating the
problem with arsenic at the genetic level."
Huffington Post December 2013
Take advantage of curcumin (the substance that gives turmeric it's bright yellow
colour) because it can dramatically improve your health. The anti-inflammatory
and antioxidant powers of curcumin prevent and fight a wide variety of
conditions ranging from sleep deprivation to stress, and beyond.
The Financial Express January 2014
The benefits for heart health arise from curcumin, an active principle which is
anti-oxidant, anti-clotting, anti-inflammatory and anti-proliferative. Several
scientific studies have documented the effect of curcumin in decreasing blood
cholesterol levels. Anti-oxidant properties of curcumin may also help prevent
cardiovascular complications among diabetics.
BMC Complement Altern Med. 2013 Dec 24
The administration of curcumin to diabetic rats normalized significantly their
blood sugar level and TBARS values and increased the activities of all
antioxidant enzymes and reduced glutathione concentration.
Atlanta Blackstar, December 2013
Researchers found 26 percent fewer fatty artery deposits in the mice fed the
curcumin-enhanced diet. Fewer atherosclerotic lesions were seen in these mice.
In addition, the researchers found that curcumin seemed to actually change the
expression of genes related to plaque buildup in arteries...After 18 weeks, the
researchers found that just like lovastatin, curcumin lowered blood levels of
cholesterol, triglycerides and LDL cholesterol, while increasing levels of HDL
(“good”) cholesterol. It also led to changes in gene expression that could be
expected to reduce the risk of artery damage and heart disease.“Long-term
curcumin treatment lowers plasma and hepatic cholesterol and suppresses early
atherosclerotic lesions comparable to the protective effects of lovastatin,” the
researchers concluded. “The anti-atherogenic effect of curcumin is mediated via
multiple mechanisms including altered lipid, cholesterol and immune gene
FoodConsumer.org December 2013
Curcumin has already been known to prevent obesity and diabetes mellitus in
animal studies and human trials...Curcumin was found to suppress oleic acid
induced lipid accumulation and lower triglycerides and total cholesterol
levels...."These results indicated that curcumin has the same ability to
activate AMPK and then reduce SREBP-1, and FAS expression, finally leading
to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this
report, we found curcumin exerted a regulatory effect on lipid accumulation
by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be
active in the prevention of fatty liver."
NaturalNews.com December 2013
Cancer cell death was observed through curcumin’s ability to reduce
pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a
time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells
to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks. The
researchers were so astounded that they proposed that curcumin may actually have
therapeutic potential in the management of colon cancer.
HeatlhNewsDigest.com Curcumin is found in
the spice turmeric, the main spice used to prepare curry. Curcumin is thought to
have antioxidant properties, as it may decrease swelling and inflammation.
Preliminary research suggests that curcumin may prevent cancer and possibly slow
the spread of cancer.
HispanicBusiness.com December 2013
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that
enters into the composition of curry, already described for its diverse and
broad biological activities, is nowadays well described as an inhibitor of DNA
methyltransferase so that it is considered as a DNA hypomethylating agent...This
dietary compound is able to restore the epigenetic regulation balance and
appears as an attractive preventive and/or therapeutic approach against human
utSanDiego.com November 2013
Some research found that curcumin may help clear the amyloid plaques found in
Alzheimer's disease. Other studies documented curcumin as a powerful
anti-inflammatory that may have a role in the cure of Alzheimer’s. Some research
has found curcumin to be a robust antioxidant, which helps ease Alzheimer's
symptoms caused by oxidation and inflammation.
Foodconsumer.org November 2013
H.M. Maier from The Florida State University in Tallahassee, Florida, USA and
colleagues reviewed studies and found evidence from animal studies indicating
that curcumin, L-arginine and vitamin E as dietary supplements can help wound
healing in people with type 2 diabetes mellitus.
anti-inflammatory role of curcumin in obesity and obesity-related
European Journal of Nutrition School of Life Sciences, College of Natural
Sciences Researchers reviewed the last
ten years of curcumin science as it applies to supporting weight
loss and preventing obesity-related disease. Their conclusion is, “The
modulation of several cellular transduction pathways by curcumin has
recently been extended to elucidate the molecular basis for obesity and
obesity-related metabolic diseases. These findings might enable novel
phytochemical treatment strategies as well as curcumin translation to
the clinical practice for the treatment and prevention of
obesity-related chronic diseases. Furthermore, the relatively low cost,
safety and proven efficacy of curcumin make it advisable to include
curcumin as part of healthy diet.”
Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and
Cytokine Research Laboratory, Department of Experimental
Therapeutics, The University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030 Extensive research within the past two decades has revealed that obesity,
a major risk factor for type 2 diabetes, atherosclerosis, cancer,
and other chronic diseases, is a proinflammatory disease. Several
spices have been shown to exhibit activity against obesity through
antioxidant and anti-inflammatory mechanisms. Among them, curcumin,
a yellow pigment derived from the spice turmeric (an essential
component of curry powder), has been investigated most extensively
as a treatment for obesity and obesity-related metabolic diseases.
Curcumin directly interacts with adipocytes, pancreatic cells,
hepatic stellate cells, macrophages, and muscle cells. There, it
suppresses the proinflammatory transcription factors nuclear
factor-kappa B, signal transducer and activators of transcription-3,
and Wnt/β-catenin, and it activates peroxisome proliferator-activated
receptor-γ and Nrf2 cell-signaling pathways, thus leading to the
downregulation of adipokines, including tumor necrosis factor,
interleukin-6, resistin, leptin, and monocyte chemotactic protein-1,
and the upregulation of adiponectin and other gene products. These
curcumin-induced alterations reverse insulin resistance,
hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.
Pharmacological basis for the role of curcumin in chronic
diseases: an age-old spice with modern target- Bokyung Sung
Cytokine Research Laboratory, Department
of Experimental Therapeutics, University of Texas M. D. Anderson
Cancer Center, Houston, TX 77030, USA Curcumin (diferuloylmethane),
a yellow pigment in the spice turmeric (also called curry
powder), has been used for centuries as a treatment for
inflammatory diseases. Extensive research within the past two
decades has shown that curcumin mediates its anti-inflammatory
effects through the downregulation of inflammatory transcription
factors (such as nuclear factor κB), enzymes (such as
cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as
tumor necrosis factor, interleukin 1 and interleukin 6). Because
of the crucial role of inflammation in most chronic diseases,
the potential of curcumin has been examined in neoplastic,
neurological, cardiovascular, pulmonary and metabolic diseases.
The pharmacodynamics and pharmacokinetics of curcumin have been
examined in animals and in humans. Various pharmacological
aspects of curcumin in vitro and in vivo
are discussed in detail.
Rack...Or Medicine Chest?
Nutrition Action Health Letter "Curcumin protects the brain cells in every animal model of
traumatic brain injury, whether it's stroke, Alzheimer's disease,
Huntington's disease, or mad cow disease," says Gregory Cole,
associate director of the Alzheimer's Disease Center at the University
of California, Los Angeles. "What's unique about Curcumin,"
Cole notes, "is that it binds directly to beta-amyloid deposits in
the brain and reduces their size." Beta-amyloid is a protein
fragment that builds up between brain cells of people with Alzheimer's
News Magazine "The list of Curcumin's effects goes on and on, and they're all in
your favor...in addition to its anti-inflammatory and antioxidant
properties, Curcumin has several effects that may work in tandem to
protect the brain from plaques in other ways. "If Curcumin had a
single molecular target, it probably would not be as good a drug,"
M.D. Anderson Cancer
Center in Houston. "But because it has multiple targets, it's very
Health: The Fires Within
Chronic inflammation may be the engine that drives many of the most
feared illnesses of middle and old age. This concept is so intriguing
because it suggests a new and possibly much simpler way of warding off
disease. Instead of different treatments for, say, heart disease,
Alzheimer's and colon cancer, there might be a single,
inflammation-reducing remedy that would prevent all three.
Science Daily Magazine
Did evolution give
us inflammatory disease? Researchers demonstrate
that some variants in our genes which could put a person at risk for
inflammatory diseases -- such as multiple sclerosis, Crohn's disease or
rheumatoid arthritis -- have been the target of natural selection over
the course of human history.
'inflammation theory': Immune-system errors linked to more illnesses
"Medical researchers are becoming increasingly convinced that the most
primitive part of the immune system (inflammation), may play a crucial role in
some of the most devastating afflictions of modern humans, including heart
disease, cancer, diabetes and possibly Alzheimer's."
Obesity is Inflammatory Disease, Rat Study Shows
led by Dr David Fairlie from the University of Queensland, Australia,
have found abnormal amounts of an inflammatory protein called PAR2 in
the fat tissues of overweight and obese rats and humans.
PAR2 is also increased on the surfaces of human immune cells by
common fatty acids in the diet. When obese rats on a diet high in sugar
and fat were given a new oral drug that binds to PAR2, the
inflammation-causing properties of this protein were blocked, as were
other effects of the high-fat and high-sugar diet, including obesity
evolution give us inflammatory disease?
American Journal of Human Genetics
Researchers demonstrate that some variants in our genes that could put a
person at risk for inflammatory diseases such as multiple sclerosis,
Crohn's disease or rheumatoid arthritis, have been the target of natural
selection over the course of human history. The findings suggest that in
the past these variants rose in frequency in the human population to
help protect us against viruses, bacteria and other pathogens. But now
in our modern world, the environment and exposure to pathogens has
changed, and the genetic variants that were originally meant to protect
us, now make an autoimmune reaction more likely.
Curcuminat M.D. Anderson Cancer Center The University of Texas, MD
Curcumin has been shown to prevent a large of number of cancers
in animal studies. Laboratory data indicate that Curcumin can
inhibit tumor initiation, promotion, invasion, angiogenesis and
Epidemiological evidence indicate that
incidence of certain cancers is less in people who consume Curcumin
than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the
treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and
anti-inflammatory effects at M. D. Anderson Cancer Center and other
Healer Scientific American Magazine
An ingredient in
curry shows promise for treating Alzheimer's, cancer and other diseases. "A chapter in a forthcoming book, for instance, describes the
biologically active components of Turmeric--Curcumin and related
compounds called Curcuminoids--as having antioxidant,
anti-inflammatory, antiviral, antibacterial and antifungal properties,
with potential activity against cancer, diabetes, arthritis, Alzheimer's
disease and other chronic maladies. And in 2005 nearly 300 scientific
and technical papers referenced Curcumin in the National Library
of Medicine's PubMed database, compared with about 100 just five years
earlier. Scientists who sometimes jokingly label
themselves Curcuminologists are drawn to the compound both
because of its many possible valuable effects in the body and its
apparent low toxicity. They ponder how the spice or its derivatives
might be used, not just as a treatment but as a low-cost preventive
medication for some of the most feared ailments. As a treatment, it also
has some enticing attributes. Because Curcumin targets so many
biological pathways, it could have benefits for cancer therapy:
malignant cells may be slow to acquire resistance to it and so might
have to go through multiple mutations to avoid the substance's
Previous news and studies on Curcumin and Turmeric.
Scientific journals with published studies of Curcumin and Turmeric.
American Journal of Physiology - 277: 320-29
Age - 18:167-9 Agents and Actions - 28:298-303
Alimentary Pharmacology and Therapeutics - 13(2):245-249
Alternative Medicine Review - 4(3):178-88, 6(2):167-187, 7(5):404-9
American Journal of Clinical Nutrition - 64(5):761-766 American Journal of Physiology: Gastrointestinal and Liver Physiology 284(1):85-95,
American Surgeon - 64(1):47-51 Annals of the New York Academy of Sciences - 973:250-4
Anticancer Drugs - 8(5):470-81
Anti Cancer Research - 11: 593-596, 19(5A):3675-80, 20(3a):1733-8, more
What is Turmeric-Curcumin.com?
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Curcumin 95% extract,
the best customer
lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5
remain dedicated and focused on the most powerful, healthful and important
compound in botanical medicine; Curcumin, concentrated and standardized
to 95% purified extract. This extraordinary spice extract has generated such
interest that universities and medical centers around the world are continually conducting
research studies and discovering new benefits, with multiple ongoing human clinical
trials. Due to it's potent antioxidant power, Curcumin has been recognized as
one of the most promising food-derived compounds in fighting a variety of
degenerative diseases. The scientific evidence remains overwhelming, demonstrating
the many health benefits via in vitro, in vivo and human clinical studies.
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