most powerful compound in botanical medicine,
the worlds most important herbal extract.
What is Turmeric and Curcumin?
Turmeric is a member of
the Curcuma botanical group, which is part of the ginger family of
herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma
longa plant is crushed and powdered into ground Turmeric. Ground Turmeric is
used worldwide as a seasoning and is the source
Curcumin is a natural component of the rhizome of Turmeric
(Curcuma longa) and one of the most studied
It is extracted, concentrated,
standardized and researched in supplement form.
direct from Turmeric-Curcumin.com, the largest supplier of
supplements at wholesale prices to the general public, research
institutions, physicians, and university medical centers for over
twelve years. Quality control tests, laboratory analysis
certification, and rigorous
standards all ensure freshness, potency, and purity of content
material. Orders are shipped FedEx
or USPS Priority for fast and secure delivery. Contact
for bulk ordering, private
labeling or any other questions. Multiple bottle orders
will receive quantity discounts listed below, 12-bottle case purchases will also
receive free US shipping.
standardized herb extract.
Health-conscious consumers should be careful in selecting a
Curcumin extract product, making sure that they know what they’re getting.
Some buyers may have heard about Curcumin
but may not be familiar with the difference between it and Turmeric, and may
confuse the two. Our extract is standardized to contain a minimum of 95%
Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC),
Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of
76:19:5. Thus, in our
product the full
spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric
(Curcuma longa root) and represented in their
natural arrangement for maximum potency.
This is the
in clinical trials and medical studies,
free of added chemicals, 'enhancements', or treatments. Unlike
many antioxidants, Curcumin is capable of both preventing free radical
formation, as well as neutralizing existing free radicals, and is considered an
effective bioprotectant due to this dual activity. We supply the purest Curcumin
available, standardized to 95% extract
milligrams per capsule.
Consumers may also be deceived by labels, believing there is
much more true Curcumin in a product than there really is due to
confusingly labeled products. Some examples of these misleading claims
which make it
difficult to tell how much active Curcumin extract is actually included
mg per serving" but the serving size is 4 capsules; 500 mg "enhanced formula"
but contains only 200 mg Curcumin extract and the rest is 300 mg Turmeric; 1000
mg "super complex" which contains only 250 grams of Curcumin extract and the
rest is 750 grams of Turmeric powder. The amount of
"Curcumin complex" is listed on the label rather than the amount of active
Curcumin extract. Thus,
a product labeled "1000 mg Curcumin (25%)"
does not even deliver 300 mg of Curcumin, since
averages only 3.14% Curcumin by weight.
Nutr Cancer. 55(2):126-31. These
deceptions are not uncommon in the supplement industry, even by the largest
vitamin shops. The solution is to compare; look for a label that clearly
indicates the contents (Curcumin extracted from Turmeric root), the
concentration (95%) and the amount (500mg) for each capsule, not per serving.
Our product contains 500 milligrams per capsule of 95% standardized Curcumin
extract. There is no claimed "enhancing" material to fill
the capsule up and lower the Curcumin
Our product contains no sugars or
other sweeteners, no artificial colors or flavors, no starch, no sodium, no soy,
no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper
extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa
corporation), no GMO, no dyes, no gums or any other
200 capsules per bottle.
For the environment as well as your finances, we
don't require purchasing two or three bottles to obtain 200 capsules. Each bottle
contains the full 200 capsules, with every 12-bottle case
totaling over two and a half
pounds of pure Curcumin extract. The
suggested serving size is one (1) to four (4) capsules with meals,
preferably with beneficial oils and fats,
potentially offsetting the inflammatory response
process that occurs during ingestion and digestion.
Are there any side effects or
interactions related to
Curcumin or Turmeric?
Why Turmeric root and its extract Curcumin may provide health benefits?
Certain plants manufacture chemicals
that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of
organic compounds that deter attackers become more successful, because of their
advanced protection. In nature's never-ending interaction between predator and prey,
insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring
this evolution between plants and insects represents an important field of
ecological research. Scientists have discovered that many
in plants and roots not only prevent insect attack or fight plant infections, but also provide
human health benefits.
Many cultures create their own botanical pharmacies as
the lore of medicinal plants and remedies is handed down through generations of
healers. With the advent
of sophisticated laboratory testing, biologists are finding that the many
indigenous plants and roots from around the world provide medicinal
value, and their metabolites are candidates for research.
Curcumin’s structure is similar to other natural polyphenolics (chemicals containing
multiple "phenol" groups) produced by
plants in response to infectious attack. These natural polyphenols often have potent
anti-oxidant and anti-inflammatory properties as well as immune support health
benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from
blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been
studied for medicinal or preventive value. Curcumin has been
studied for anti-oxidant, anti-inflammatory,
antiviral, antibacterial, antifungal, and anticancer activities, mediated
through the regulation of various transcription factors, growth factors,
inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits
activities similar to recently discovered TNF blockers (humira, remicade and
enbrel), vascular endothelial cell growth factor blocker (avastin), human
epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib),
and HER2 blocker (herceptin). Considering the recent scientific bandwagon that
multi-targeted therapy is better than mono-targeted therapy for most diseases,
Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000
papers published within the past two decades have revealed that Curcumin has
extraordinary potential in promoting health through modulation of numerous molecular
What is the history of Curcumin and Turmeric?
Turmeric is an ancient spice and a traditional remedy. Its health benefits have
been described for thousands of years in
traditional Indian (Ayruvedic) and Chinese medicine largely because of its
proven efficacy in treating conditions with inflammation. These ancient
civilizations have vast trial and error experience with many different herbal
remedies and food preparations and they selected curcumin as a food additive and
major tool for medicinal use based on efficacy.
Since 1900 BC numerous therapeutic
activities have been assigned to Turmeric for a wide variety of diseases and
conditions, including those of the skin, pulmonary, and gastro-intestinal
systems, aches, pains, wounds and disorders. Marco Polo, writing of his travels in China, described
Turmeric in the 13th century: "There
is also a vegetable which has all the properties of the true saffron, as well as
the color, and yet it is not really saffron. Turmeric
is held in great estimation, and being an ingredient in all their dishes, it
bears, on that account, a high price." The high degree of reverence
established by the fact
that it is used in many cultures, each having its own name for the
geung fun, yü chiu. Danish:gurkemeje. Dutch:geelwortel.
Finnish:keltajuuri. French: curcuma, saffron des Indes.
German:gelbwurz, kurkuma. Icelandic:turmerik.
Indian:haldee, haridra, haldi, huldee, huldie.
Indonesian:kunjit, kunyit. Japanese:ukon circumin Malay:kunjit.
kurkumy. Portuguese:açafrão-da-Índia. Russian:zholty
imbir. Spanish:azafrán de la
India, azafran arabe. Sinhalese:kaha. Swedish:gurkmeja.
Tamil:munjal. Thai:ka min. Vietnamese:bot
the pharmaceutical industry patented Curcumin?
the studied pharmacological actions of Curcumin?
Anti-inflammatory, Anticancer (Anticarcinogenic), Prostate Cancer, Breast Cancer, Ovarian Cancer, Colon cancer, Rectal cancer, Skin cancer, Melanoma, Antiphlogistic, Anti-Diabetes,
Antiproliferative, Antianglogenic, Antimetastatic, Antitumoral, Antihypertensive, High-Blood Pressure, Antihepatotoxic Action
Antimutagenic Action, Anti-Excessive Fluid (Antiedemic), Antihyperlipemic, Hypolipidemic, Antithrombotic Activity, Anti Psoriasis, Protects Against Kidney Injury, Anticoagulant - Prevents blood clotting, Prevention of Memory Loss, Chemoprotective,
Neutralizing of Free Radicals, Inflammatory Bowel Disease ,Ulcerative
Colitis Protection Diabetic Retinopathy, Antiangiogenic, Increases HDL (Good) Cholesterol levels,
Cholagogue, Lowers LDL (bad) cholesterol
Hepatoprotective, Antimicrobial, Anti-tumor, Suppresses Tumor Growth, Antiviral, Antiparasitic, Anti Cystic Fibrosis, Chronic Fatigue Syndrome, Depurative - Promotes excretion and removal of waste material, Anti-HIV - Inhibits Interleukin-1,
Proapoptotic, Anti-amyloidogenic prevention of Alzheimer's disease, Antihypercholesterolemic, Helps prevent oxidation of blood cholesterol, Helps protect against or lessen the degree of kidney lesions, Antioxidant, protects against free radical damage, Angiogenesis, the generation of new blood vessels, Prevention of degenerative bone loss (Osteoporosis), Prevention of joint stiffness (Arthritis), Carminative, Increases digestive fluids and reduces gas,
Cardiovascular protection and heart disease
How may Curcumin work against cancer?
Independent research studies on suggest that Curcumin has the potential for
treatment of cancers including colon, breast, prostate, lung, skin and bowel.
Curcumin is one of the most powerful and promising chemopreventive and
anticancer agents, and epidemiological evidence demonstrates that people who
incorporate high doses of this spice in their diets have a lower incidence of
cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic
investigators around the world. Because of low
toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology
testing and has successively made it through the first stages (Phase I) of
clinical testing abroad and is currently in clinical trials at several sites in
the U.S. Numerous mechanisms have been
described for the anticancer activity of Curcumin. Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin
has “enormous” potential to prevent and treat cancer. Curcumin was able to
suppress tumor formation, growth, and even metastasis according to their review.
Currently, there are clinical trials being conducted on the effects of Curcumin
on patients with bowel cancer. Inhibition of proliferation
of tumor cells, induction of apoptosis (a mode of cell death), inhibition of
transformation of cells from normal to tumor, inhibition of invasion and
metastasis and suppression of inflammation have been linked with the
activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules,
inflammatory cytokines, chemokines, growth factor receptors, vascular
endothelial growth factor (VEGF) and transcription factors by Curcumin have been
linked to its antitumor activity. Curcumin also has been studied with
the core inflammatory gene signal, NF-kappaB,
resulting in a beneficial domino effect throughout the body. One benefit of this
domino effect is a direct reduction in the risk of cancer from
How may Curcumin work against
Arthritis is also a proinflammatory
disease. All current drugs approved for arthritis have anti-inflammatory
activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this
disease. Curcumin has been shown to both suppress the TNF production, block
the action of TNF, and have
activity against arthritis.
When inflammation is reduced, the added benefit is
pain relief. A double-blind, crossover study showed that Curcumin may be effective
in relieving pain and improvements in morning stiffness, walking time, and joint
How may Curcumin work against
Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved
for this disease have anti-inflammatory activity. Anti-TNF therapy has been
approved for this disease. Curcumin has been shown to both suppress the TNF
production and the TNF action. Curcumin taken orally has been shown to have
activity against inflammatory bowel disease. Study results
suggest that Curcumin could have a protective role in ulcerative colitis via
regulation of oxidant/anti-oxidant balance and modulation of the release of some
inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced
colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK
signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and
the nitrite production in colonic mucosa, reducing the development of chronic
experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative
How may Curcumin work against
Curcumin acts directly on liver cells to help
prevent them from becoming fatty, and studies have concluded that Curcumin may
have an anti-diabetic effect by decreasing serum fatty acid through the
promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells
to help them produce insulin normally. By helping the liver and the pancreas,
Curcumin is taking stress off the two most important organs whose function
declines before the onset of type 2 diabetes. Curcumin also influences key
hormones, supports major body organs, and regulates inflammatory signaling all
in ways that help correct or prevent metabolic problems. Curcumin helps lower
inappropriately high levels of leptin (reducing leptin resistance) while
boosting the all-important levels of the adiponectin
(which lowers insulin resistance). Curcumin also helps activate the fat-burning
gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat
cells. Curcumin directly reduces major inflammatory events from occurring inside
white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte
chemotactic protein-1). By lowering such inflammation, the source of
overweight-induced disease is targeted.
How may Curcumin work against
In the prevention and treatment of obesity and metabolic
syndrome, Curcumin has been reported to modulate numerous targets that have been
linked to obesity and insulin resistance. First, Curcumin has been shown to
downregulate the expression of TNF in various tissues. Second, our laboratory
was the first to demonstrate that Curcumin can suppress NF-κB activation induced
by a wide variety of inflammatory agents through inhibition of degradation of
IκBα. Third, Curcumin can inhibit the activation of IKK linked to the activation
of NF-κB, and this leads to the suppression of expression of inflammatory
biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth
factor. Fourth, the spice has been shown to downregulate the expression of
various NF-κB-regulated proinflammatory adipocytokines including chemokines
(such as MCP-1, MCP-4, and eotaxin) (199)
and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression
of plasminogen activator inhibitor type-1 through the inhibition of the
transcription factor early growth response (Egr)-1 gene product that has been
closely linked with insulin resistance and obesity. Fifth, it has been reported
to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate
cells. Sixth, this nutraceutical has been shown to downregulate activation of
c-Jun NH2 terminal kinase. Seventh, Curcumin has been shown to inhibit the Wnt/β-catenin
pathway, which is closely linked to obesity. Later studies have indicated that
Curcumin inhibits Wnt pathway signaling through downregulation of the
transcription coactivator p300. Another potential mechanism by which Curcumin
could inhibit β-catenin signaling is through inhibition of glycogen synthase
kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin.
Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32).
Eighth, the spice has been shown to induce the expression of hemeoxygenase
(HO)-1 through the activation of Nrf2 in pancreatic cells and thus mediate the
survival of these cells. Ninth, curcumin downregulates the secretion of
insulin-like growth factor-1 but induces the expression of insulin-like growth
factor binding protein-3. Tenth, this nutraceutical interrupts leptin signaling
by reducing phosphorylation levels of the leptin receptor (Ob-R) and its
downstream targets. In addition, curcumin suppresses gene expression of Ob-R in
HSCs. Finally, curcumin has been reported to increase the expression of
adiponectin, which negatively controls obesity.
How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory
disease. Considerable evidence, both in animals and humans, indicates that Curcumin
may be effective against psoriasis.
How may Curcumin work against Alzheimer's
Researchers found that Curcumin
not only reduces oxidative damage and inflammation, but also
reduces amyloid accumulation and synaptic marker loss and promotes amyloid
phagocytosis and clearance. Curcumin worked to prevent synaptic marker and
cognitive deficits caused by amyloid peptide infusion and abeta oligomer
toxicity in vitro, and may help the immune system clear the
brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin
for Alzheimer's. In the
Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that
reducing inflammation has positive effects on patients with Alzheimer’s.
Curcumin significantly lowered several inflammation markers, in addition to
reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent.
How may Curcumin work
as an Anti-inflammatory?
Turmeric is safe and non-toxic and
has been studied for anti-inflammatory properties, inhibiting various molecules that
contribute to inflammation such as lipooxygenase, COX-2, leukotrienes,
prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis
factor (TNF), and interleukin-12 (IL-12). One study compared the
effectiveness of Curcumin – the active ingredient in turmeric – and a popular
non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end
of the six days, those taking the Curcumin and the NSAID enjoyed a significantly
better anti-inflammatory response than placebo. The spice worked as well as the
drug, but without the negative side effects.
Recent news and published studies on Curcumin and Turmeric
Food Consumer 2013 May
Curcumin an ingredient found in turmeric has been used to prevent many chronic
diseases including obesity, type type 2 diabetes and liver disease. Recent
studies show that this dietary supplement possesses potent antioxidant,
anticarcinogenic, antiinflammatory and hypoglycemic properties.
Food Funct. 2013 Apr
This study provides compelling evidence of the pharmacodynamic additive effect
of limonoids and curcumin in inhibiting human colon cancer cells. These results
suggest that consumption of curcumin and limonoids together may offer greater
protection against colon cancer.
CNS Neurol Disord Drug Targets. 2013 Apr
Curcumin, the major constituent of the spice turmeric produces a plethora of
biological actions that have translated in vivo into behavioral and
neurochemical effects in rodents that are also produced by clinically-used
Pharmacol Toxicol. 2013 Apr
Curcumin is a well-known component of traditional turmeric (Curcuma longa),
which has been reported to prevent obesity and diabetes. The levels of total
cholesterol, fasting glucose and insulin in serum were decreased, and HFD-induced
impairment of insulin sensitivity was improved by curcumin supplementation
Exp Dermatol. 2013 Apr
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma
longa), which is commonly used as a spice. Recent studies have shown that
curcumin has a wide range of pharmacological activities, including
anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic
activities.... Curcumin prevented UVB-induced MMP expression
Biogerontology. 2013 Apr
Curcumin is the active component of curcuma longa and has shown antioxidant,
antiinflamatory and neuroprotective properties...curcumin supplementation
improves cognitive functions by decreasing the lipid peroxidation in brain
tissue of aged female rats.
Curr Med Chem. 2013 Apr
Curcumin is the major yellow pigment extracted from turmeric, a commonly used
spice in Asian cuisine that is used extensively in ayurvedic herbal remedies. A
number of studies have shown that curcumin can be a prevention agent and a
chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is
also well-known for its anti-inflammatory and antioxidant properties, showing
high reactivity towards peroxyl radicals, and thus acting as a free radical
Curr Cancer Drug Targets. 2013 Apr
Accumulating evidence has demonstrated that some common natural products (such
as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN)
and resveratrol) have anticancer properties through the mechanisms of altering
epigenetic processes and targeting cancer stem cells (CSCs). These bioactive
compounds are able to revert epigenetic alterations in a variety of cancers in
vitro and in vivo. They exert the anticancer effects by targeting various
signaling pathways related to the initiation, progression and metastasis of
cancer. It appears that natural products hold great promise for cancer
prevention and treatment by altering various epigenetic modifications.
Mol Cell Biochem. 2013 Apr
Curcumin, a phytochemical, has a wide variety of biological actions including
anti-inflammatory and antioxidative....the formation of protein carbonyls in the
liver of the aging mice can be prevented by the antioxidative effects of
melatonin and curcumin, which may provide health benefits in aging animals.
Food Chem. 2013 Apr
Curcumin, the active constituent of dietary spice turmeric, possesses a strong
potential for cancer prevention and treatment...The findings showed that
curcumin might be an effective tumouristatic agent for the treatment of
aggressive papillary thyroid carcinomas.
PLoS One. 2013 Apr
Curcumin administration significantly reduced infarct size. Curcumin also
markedly reduced oxidative stress levels in middle cerebral artery occlusion (MCAO)
rats; Taken together, these findings provide evidence that curcumin protects
neurons against ischemic injury, and this neuroprotective effect involves the
Akt/Nrf2 pathway. In addition, Nrf2 is involved in the neuroprotective effects
of curcumin against oxidative damage.
Curcumin Controls Blood Sugar: It switches on the liver genes that
keep glucose levels in check. It improves the pancreas’s ability to
make insulin and helps slow down the metabolism of carbohydrates
after meals. Curcumin Fights Cancer: It inhibits the genetic switches
that allow for cancerous cell growth to occur. Curcumin Speeds Up
Metabolism: USDA research shows that is enhances cellular energy to
speed metabolism. Curcumin Clears Plaque: It removes amyloyd plaque
buildup in the brain that can cause Alzheimer’s.
active ingredient of turmeric, is proved to be a potential
candidate of controlling inflammation and bone resorption
(and) may decrease alveolar bone loss in the experimental
periodontitis rats via suppressing the expression of RANKL/RANK/OPG
and its anti-inflammatory properties.
Curcumins, derived from the spice turmeric, and
resveratrol, polyphenols found in grapes and red wine
respectively, in addition to their antioxidant and
anti-inflammatory properties, inhibit preadipocyte
proliferation, de novo lipogenesis and fat accumulation in
liver....The therapeutic use of
and resveratrol, in the context of obesity as an initiator of
insulin resistance and hypertension, the two main features of
MS, together with the underlying mechanisms of action.
Curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC)
have been demonstrated as having antioxidant, anticarcinogenic, and
hypocholesterolemic activities. We report the diverse
antiatherogenic effects and mechanisms of curcuminoids. Curcumin
was the most potent antioxidant.
Curcumin is known to have antioxidant and
anti-inflammatory properties. Curcumin
treatment improved gastric emptying by blocking the production
of oxidative stress, abolishing NF-kappaB signal transduction
and enhancing expression of SCF/c-kit in rats with diabetic
Curcumin is a known cytoprotectant with
comprehensive anti-inflammatory and anti-cancerous
properties...Curcumin should be investigated as a potential safe
and remarkable approach in attenuating the adverse effects
induced by CP-related toxicants.
J Neuroimmune Pharmacol.
Curcumin could be a candidate neuroprotective agent by
inducing macroautophagy, and needs to be further investigated by
clinical application in patients suffering Parkinson's disease.
Curcumin is known to have antioxidant
and anti-inflammatory properties. Curcumin treatment improved
gastric emptying by blocking the production of oxidative stress,
abolishing NF-kappaB signal transduction and enhancing expression of
SCF/c-kit in rats with diabetic gastroparesis.
Oncol Rep. 2013 Feb
Curcumin and resveratrol are the major anticancer constituents
of Curcuma aromatica and Polygonum cuspidatum, respectively.
Curcumin and resveratrol have been found to exhibit a
synergistic anticancer effect in colon cancer...Curcumin and
resveratrol is a promising novel anticancer strategy for liver
cancer. The present study also provides new insights into the
effective mechanism of paired-herbs in traditional Chinese
J Physiol Biochem. 2013 Feb
Curcumin is extracted from the rhizome Curcuma longa and has
been shown to possess potent antioxidant, anticarcinogenic,
anti-inflammatory, and hypoglycemic properties...Curcumin
treatment appeared to be effective in reducing liver
triglycerides and serum fetuin-A levels. These findings suggest
that the reduction of fetuin-A may contribute to the beneficial
effects of curcumin in the pathogenesis of obesity.
Integr Cancer Ther. 2013 Feb
A list of leading supplements that have the best suggestions of
benefit was constructed by leading researchers and clinicians
who have experience in using these supplements. This list
Br J Pharmacol. 2013 Feb
Curcumin (diferuloylmethane), a component of turmeric (Curcuma
longa) that is very inexpensive, orally bioavailable, and highly
safe in humans, yet can block TNF-α action and production in in
vitro models, in animal models, and in humans. In addition, we
provide evidence for curcumin's activities against all of the
diseases for which TNF blockers are being used.
Behav Brain Res. 2013 Feb
Department of Pharmacology, Howard University College of Medicine
Curcumin is the principal active ingredient found in turmeric
(Curcuma longa), a plant used in traditional Asian diets and herbal
medicines. It is known to have a wide range of biological actions
including antidepressant-like effects which have been observed in
stress-induced depression models...Evidence for an
antidepressant-like effect of curcumin, possibly through increased
neurotrophic activity, in the WKY model of depression, and support
the notion that curcumin may prove an effective and lasting natural
Curcumin, a natural polyphenolic
antioxidant compound, exerts well-known anti-inflammatory and
immunomodulatory effects, the latter which can influence the
activation of immune cells including T cells. Furthermore, curcumin
can inhibit the expression of pro-inflammatory cytokines and
chemokines, through suppression of the NF-κB signaling pathway. The
beneficial effects of curcumin in diseases such as arthritis,
allergy, asthma, atherosclerosis, diabetes and cancer may be due to
its immunomodulatory properties.
Curcumin, a major
active component of spic turmeric, could increase the capacity of
learning and memory in the aged rat...Curcumin treatment could
attenuate cognitive deficits of SAMP8 mice in a dose-dependent
manner by decreasing the oxidative stress and improving the
expression of p-CaMKII and p-NMDAR1 in the hippocampus. Thus
treatment with curcumin may have a potential therapeutic agent for
aging-related cognitive dysfunctions.
Otolaryngol Head Neck Surg. 2013
Curcumin, a naturally occurring food substance and anticarcinogenic
agent, inhibited cutaneous squamous cell carcinoma xenograft
growth...Curcumin appears to inhibit skin cancer formation and
prolong time to tumor onset when administered by either an oral or
Exp Gerontol. 2013 Feb
Curcumin supplementation ameliorates age-associated large elastic
artery stiffening, vascular endothelial dysfunction, oxidative
stress and increases in collagen and AGEs in mice...Curcumin may be a
novel therapy for treating arterial aging in humans.
Some substances, such as Zn, s-Ethyl cysteine, s-propyl cysteine,
citicoline, rivastigmine, Vit E, memantine, tea polyphenol, curcumin,
caffeine, Alpinia galanga (L.) fractions, and Bacopa monnieri could
play a role in improving memory performance and exert protective
effects against Alzheimer
Endocrinology Section, Department of Medicine, The
University of Arizona-Feb
The structural and biological
importance of curcuminoids in the anti-breast cancer effects of
turmeric and contradict recent assertions that certain of the
curcuminoid metabolites studied here mediate these anti-cancer
GroundReport Jan 2, 2013
Curcumin with its rich anti-inflammatory components. The spice is widely
used in India and it's interesting to note that elderly villagers in
India have one of the world's lowest rates of Alzheimer's.
Researchers from the Department of Neurosurgery at the David Geffen
School of Medicine and the Department of Integrative Biology and
Physiology at UCLA have found that a diet enriched with
docosahexaenoic acid (DHA), an omega-3 fatty acid, and curcumin ...
The second group consumed a standard diet supplemented with
docosahexaenoic acid, or DHA, and curcumin, a compound in
turmeric, an Indian curry spice. A third set of rats received a
standard rat diet and served as a control group.
Washington, June 27 — A diet enriched with a popular omega-3 fatty
acid and curcumin, found in Indian curry spice turmeric,
preserved walking ability in rats with spinal-cord injury. The
findings by researchers from the University of California Los ...
WASHINGTON: A diet enriched with curcumin, a component of the
popular Indian spice turmeric, and omega-3 fatty acid DHA can repair
tissue damage and restore walking abilities in rats with spinal-cord
injury, a new study claims.
Researchers at UCLA found that rats with spinal cord damage
recovered faster when fed a diet rich in omega-3 compound DHA and
curcumin, often found in curry. Omega-3 fatty acid-rich foods
such as flax seeds (above) may help to improve walking ability
Dr. Mike carries a mustard pack in his pocket to get a daily dose of
curcumin, the power drive in turmeric (it's what makes
mustard yellow) that protects ...
anti-inflammatory role of curcumin in obesity and obesity-related
Eur J Nutr. 2011 Apr;50(3):151-61. Epub 2011 School of Life Sciences, College of Natural
Sciences Researchers reviewed the last
ten years of curcumin science as it applies to supporting weight
loss and preventing obesity-related disease. Their conclusion is, “The
modulation of several cellular transduction pathways by curcumin has
recently been extended to elucidate the molecular basis for obesity and
obesity-related metabolic diseases. These findings might enable novel
phytochemical treatment strategies as well as curcumin translation to
the clinical practice for the treatment and prevention of
obesity-related chronic diseases. Furthermore, the relatively low cost,
safety and proven efficacy of curcumin make it advisable to include
curcumin as part of healthy diet.”
Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and
Cytokine Research Laboratory, Department of Experimental
Therapeutics, The University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030 Extensive research within the past two decades has revealed that obesity,
a major risk factor for type 2 diabetes, atherosclerosis, cancer,
and other chronic diseases, is a proinflammatory disease. Several
spices have been shown to exhibit activity against obesity through
antioxidant and anti-inflammatory mechanisms. Among them, curcumin,
a yellow pigment derived from the spice turmeric (an essential
component of curry powder), has been investigated most extensively
as a treatment for obesity and obesity-related metabolic diseases.
Curcumin directly interacts with adipocytes, pancreatic cells,
hepatic stellate cells, macrophages, and muscle cells. There, it
suppresses the proinflammatory transcription factors nuclear
factor-kappa B, signal transducer and activators of transcription-3,
and Wnt/β-catenin, and it activates peroxisome proliferator-activated
receptor-γ and Nrf2 cell-signaling pathways, thus leading to the
downregulation of adipokines, including tumor necrosis factor,
interleukin-6, resistin, leptin, and monocyte chemotactic protein-1,
and the upregulation of adiponectin and other gene products. These
curcumin-induced alterations reverse insulin resistance,
hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.
Pharmacological basis for the role of curcumin in chronic
diseases: an age-old spice with modern target- Bokyung Sung
Cytokine Research Laboratory, Department
of Experimental Therapeutics, University of Texas M. D. Anderson
Cancer Center, Houston, TX 77030, USA Curcumin (diferuloylmethane),
a yellow pigment in the spice turmeric (also called curry
powder), has been used for centuries as a treatment for
inflammatory diseases. Extensive research within the past two
decades has shown that curcumin mediates its anti-inflammatory
effects through the downregulation of inflammatory transcription
factors (such as nuclear factor κB), enzymes (such as
cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as
tumor necrosis factor, interleukin 1 and interleukin 6). Because
of the crucial role of inflammation in most chronic diseases,
the potential of curcumin has been examined in neoplastic,
neurological, cardiovascular, pulmonary and metabolic diseases.
The pharmacodynamics and pharmacokinetics of curcumin have been
examined in animals and in humans. Various pharmacological
aspects of curcumin in vitro and in vivo
are discussed in detail.Trends
Pharmacol Sci. 2009 Feb;30(2):85-94. Epub 2008 Dec 26
Rack...Or Medicine Chest?
Nutrition Action Health Letter "Curcumin protects the brain cells in every animal model of
traumatic brain injury, whether it's stroke, Alzheimer's disease,
Huntington's disease, or mad cow disease," says Gregory Cole,
associate director of the Alzheimer's Disease Center at the University
of California, Los Angeles. "What's unique about Curcumin,"
Cole notes, "is that it binds directly to beta-amyloid deposits in
the brain and reduces their size." Beta-amyloid is a protein
fragment that builds up between brain cells of people with Alzheimer's
News Magazine "The list of Curcumin's effects goes on and on, and they're all in
your favor...in addition to its anti-inflammatory and antioxidant
properties, Curcumin has several effects that may work in tandem to
protect the brain from plaques in other ways. "If Curcumin had a
single molecular target, it probably would not be as good a drug,"
M.D. Anderson Cancer
Center in Houston. "But because it has multiple targets, it's very
Health: The Fires Within
Chronic inflammation may be the engine that drives many of the most
feared illnesses of middle and old age. This concept is so intriguing
because it suggests a new and possibly much simpler way of warding off
disease. Instead of different treatments for, say, heart disease,
Alzheimer's and colon cancer, there might be a single,
inflammation-reducing remedy that would prevent all three.
'inflammation theory': Immune-system errors linked to more illnesses
"Medical researchers are becoming increasingly convinced that the most
primitive part of the immune system (inflammation), may play a crucial role in
some of the most devastating afflictions of modern humans, including heart
disease, cancer, diabetes and possibly Alzheimer's."
evolution give us inflammatory disease?
American Journal of Human Genetics
Researchers demonstrate that some variants in our genes that could put a
person at risk for inflammatory diseases such as multiple sclerosis,
Crohn's disease or rheumatoid arthritis, have been the target of natural
selection over the course of human history. The findings suggest that in
the past these variants rose in frequency in the human population to
help protect us against viruses, bacteria and other pathogens. But now
in our modern world, the environment and exposure to pathogens has
changed, and the genetic variants that were originally meant to protect
us, now make an autoimmune reaction more likely.
Curcuminat M.D. Anderson Cancer Center The University of Texas, MD
Curcumin has been shown to prevent a large of number of cancers
in animal studies. Laboratory data indicate that Curcumin can
inhibit tumor initiation, promotion, invasion, angiogenesis and
Epidemiological evidence indicate that
incidence of certain cancers is less in people who consume Curcumin
than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the
treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and
anti-inflammatory effects at M. D. Anderson Cancer Center and other
Healer Scientific American Magazine
An ingredient in
curry shows promise for treating Alzheimer's, cancer and other diseases. "A chapter in a forthcoming book, for instance, describes the
biologically active components of Turmeric--Curcumin and related
compounds called Curcuminoids--as having antioxidant,
anti-inflammatory, antiviral, antibacterial and antifungal properties,
with potential activity against cancer, diabetes, arthritis, Alzheimer's
disease and other chronic maladies. And in 2005 nearly 300 scientific
and technical papers referenced Curcumin in the National Library
of Medicine's PubMed database, compared with about 100 just five years
earlier. Scientists who sometimes jokingly label
themselves Curcuminologists are drawn to the compound both
because of its many possible valuable effects in the body and its
apparent low toxicity. They ponder how the spice or its derivatives
might be used, not just as a treatment but as a low-cost preventive
medication for some of the most feared ailments. As a treatment, it also
has some enticing attributes. Because Curcumin targets so many
biological pathways, it could have benefits for cancer therapy:
malignant cells may be slow to acquire resistance to it and so might
have to go through multiple mutations to avoid the substance's
Previous news and studies on Curcumin and Turmeric.
Scientific journals with published studies of Curcumin and Turmeric.
American Journal of Physiology - 277: 320-29
Age - 18:167-9 Agents and Actions - 28:298-303
Alimentary Pharmacology and Therapeutics - 13(2):245-249
Alternative Medicine Review - 4(3):178-88, 6(2):167-187, 7(5):404-9
American Journal of Clinical Nutrition - 64(5):761-766 American Journal of Physiology: Gastrointestinal and Liver Physiology 284(1):85-95,
American Surgeon - 64(1):47-51 Annals of the New York Academy of Sciences - 973:250-4
Anticancer Drugs - 8(5):470-81
Anti Cancer Research - 11: 593-596, 19(5A):3675-80, 20(3a):1733-8, more
What is Turmeric-Curcumin.com?
Turmeric-Curcumin.com is the name of our
company and website, founded by researchers who believe the best prescription is
knowledge. Since the year 2000,
our company philosophy has been to offer the
certified highest quality Curcumin
the best customer
lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5
remain dedicated and focused on the most powerful, healthful and important
compound in botanical medicine; Curcumin, concentrated and standardized
to 95% purified extract. This extraordinary spice extract has generated such
interest that universities and medical centers around the world are continually conducting
research studies and discovering new benefits, with multiple ongoing human clinical
trials. Due to it's potent antioxidant power, Curcumin has been recognized as
one of the most promising food-derived compounds in fighting a variety of
degenerative diseases. The scientific evidence remains overwhelming, demonstrating
the many health benefits via in vitro, in vivo and human clinical studies.
You will receive 100% additive free products; no sugars or other sweeteners, no artificial
colors or flavors, no starch, no sodium,
no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a
trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums or any
other unnecessary compounds. You
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