“One of the greatest beneficial medicinal plants in the entire world...
one of the most researched medicinal plants in history.”
- Chris Kilham

 

  What is Turmeric and Curcumin?
Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma longa plant is crushed and powdered into ground Turmeric spice. Ground Turmeric is used worldwide as a seasoning and is the source of extracted Curcumin.
curcumin turmeric

curcumin turmeric
Curcumin is a natural component of the rhizome of Turmeric and one of the most studied phytochemicals in science. Turmeric contains approximately 3% Curcumin, which is extracted until it is 95% pure to be researched or supplemented.

 

  What are the researched properties of Curcumin? 

"As of January 2015, there are nearly 5,000 studies and articles on Curcumin or Turmeric listed in the National Institutes of Health PubMed database" - Fox News, 2015

"PubMed.com, a research database maintained by the National Institutes of Health, lists 7,728 studies involving curcumin and another 3,205 studies involving turmeric, with the large majority focused on their effectiveness against multiple medical conditions." - Post Gazette, 2015

"Curcumin alone has been subject to more than 1,000 studies in 2014." - Natural Products Insider, December 2014

"More than 6.000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical.- MD Anderson Cancer Center, Houston, TX, December 2014

"Curcumin has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. - Cancer Research and Treatment, 2014

"Over 100 clinical trials on curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer." - Cytokine Research Laboratory, The University of Texas, December 2014

"Extensive research over the past 30 years has shown that Curcumin plays an important role in the prevention and treatment of various pro-inflammatory chronic diseases including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and malignant diseases." - Cancer Research and Treatment, 2014

"Curcumin is the most widely-studied plant-derived medicinal chemical in modern science...based on a statistical analysis of over three million published scientific studies, Curcumin is the most frequently mentioned phytonutrient." - NaturalNews.com, 2013

"The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive." - Science News Magazine

 
  Where can I purchase Curcumin?
Order direct from Turmeric-Curcumin.com, the largest supplier of Curcumin supplements at wholesale prices to the general public, research institutions, physicians, and university medical centers for over fourteen years. Quality control tests, laboratory analysis certification, and rigorous cGMP manufacturing standards all ensure freshness, potency, and purity of content material. Orders are shipped FedEx or USPS Priority for fast and secure delivery. Contact support@turmeric-curcumin.com for bulk ordering, private labeling or any other questions. Multiple bottle orders will receive quantity discounts listed below, 12-bottle case purchases will also receive free US shipping.


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  500 mG OF Curcumin 95% extract per capsule.

Health-conscious consumers should be careful in selecting a Curcumin extract product, specifically knowing the difference between Curcumin and Turmeric. Consumers may be misled by deceptive labels, believing there is much more true Curcumin extract in a product than there really is. Some examples of these misleading claims make it difficult to tell how much active Curcumin extract is actually included, because they are substituting Turmeric spice powder, which averages only 3% Curcumin by weight. - 55(2):126-31. Some examples of these deceptions are:

"Doctors Turmeric Curcumin" on the front of the label, but checking the ingredient finds that each capsule is 100% Turmeric (curcuma longa), a common and inexpensive spice found in supermarkets and grocery stores.

"500 mg Enhanced Formula" but only contains 200 mg Curcumin extract, and the remainder is 300 mg Turmeric spice.

"1000 mg Super Complex Curcumin (25%)" which is actually only 250 mg of Curcumin extract and the remaining 750 mg is Turmeric spice.

"1000 mg per serving" but one serving size is 4 capsules, 250 mg each.

These deceptions are not uncommon in the supplement industry, even by the largest vitamin shops. The solution is to compare. Our label clearly indicates the contents (Curcumin extracted from Turmeric root), the purity concentration (95%) and the amount (500mg) for each capsule, not per serving. Our product contains 500 milligrams per capsule of 95% standardized Curcumin extract. Our extract is standardized to contain a minimum of 95% Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC), Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of 76:19:5. Thus, in our product the full spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric (Curcuma longa root) and represented in their natural arrangement for maximum potency. This is the same material used in clinical trials and medical studies, free of added chemicals, 'enhancements', or treatments. Unlike many antioxidants, Curcumin is capable of both preventing free radical formation, as well as neutralizing existing free radicals, and is considered an effective bioprotectant due to this dual activity. We supply the purest Curcumin available, standardized to minimum 95% extract.There is no claimed "enhancing" material to fill the capsule up and lower the Curcumin percentage. Our product contains no sugars or other sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums.

 

  200 capsules per bottle.

For the environment as well as your finances, we don't require purchasing two or three bottles to obtain 200 capsules. Each bottle contains the full 200 capsules, with every 12-bottle case totaling over two and a half pounds of pure Curcumin extract. The suggested serving size is one (1) to four (4) capsules with each meal, preferably with beneficial oils and fats, potentially offsetting the inflammatory response process that occurs during ingestion and digestion.
 

  Are there any side effects or interactions related to Curcumin or Turmeric?

Turmeric has been used in large quantities as a condiment for thousands of years with no adverse reactions. The US FDA classifies Turmeric as GRAS (Generally Recognized As Safe). Pregnant women, individuals with gallstones or using blood thinners should consult a health care provider before using herbs or dietary supplements in amounts greater than usually found in foods.

"Curcumin is not toxic to humans up to 8,000 mg/day."- Phase I Clinical Trial of Curcumin, 21(4B):2895-900. 

"Patients received 8 g curcumin by mouth daily...No toxicities were observed." -  Phase II ClinicalTrial of Curcumin, Clin Cancer Res. 14(14):4491-9.

"Curcumin, even in large quantities, does not produce any known side effects in humans." - Blood.101(3):1053-62.

 

  Has the absorption of ORAL Curcumin 95% DELIVERY been studied?

In most studies Curcumin 95% has been delivered orally whether the subject is human or animals. This orally delivered Curcumin 95% extract showed several biological effects such as antioxidant, anti-inflammatory, antidiabetic, and anticancer beneficial effects in several types of cancer in patients.

"Orally administered curcumin inhibited inflammatory cytokines such as TNF, cyclooxygenase (COX)-2, inducible nitric oxide synthase in mice indicating its anti-inflammatory activity and further suppressing dextran sodium sulfate-induced colon carcinogenesis." - Biofactors. 2013

"Clinical trials have shown that orally delivered curcumin inhibited inflammatory molecules." - AAPS Journal. 2013

 
  Has the bioavailability of Curcumin 95% EXTRACT been studied?
"In a human clinical trial, 3.6 g of Curcumin via oral route was found to produce a plasma curcumin level of 11.1 nmol/L after an hour of dosing." - Clin Cancer Research

"The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM, respectively." - Phase I Clinical Trial of Curcumin,

"Traces of curcumin were detected in the plasma. Its concentration in the small intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects differences in dietary concentration...The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g of curcumin is required for efficacy in humans." - Journal Cancer Epidemiol Biomarkers

 

  What are the studied pharmacological actions of Curcumin?

Cancer (46), Ovarian cancer (42), pituitary (41), Tumor (40), Cirrhosis (39), radiation (38), blood (38), Inflammatory (37), colon cancer (37), prostate (37), Cytotoxicity (36), Melanoma (36), Hypothyroid (36), prostate cancer (36), Colitis (36), Anti-Inflammatory (35), Chemopreventive (34), breast cancer (34), Seizures (34), HPV (34), Antiviral (34), Granuloma (34), Pulmonary fibrosis (33), Leukemia (33), Osteosarcoma (33), Apoptotic (33), diabetes (34), Allergy (33), endometriosis (33), skin (33), Antioxidants (33), Squamous cell carcinoma (33), Liver damage (32), Colorectal cancer (32), chemotherapy (32), lymphoma (32), neurons (32), Neuroprotective (32), Anti-Apoptotic (32), Antimicrobial (32), Oxidant (32), Neurogenesis (32), Gastric cancer (32), Schistosomiasis (31), Neuroblastoma (31), Sepsis (31), Death (31), Emphysema (31), alzheimer's (31), Proteasome Inhibitors (31), Hepatoma (31), cartilage (31), Cytotoxic (31), Antifungal (33), spinal cord (31), Pancreatitis (30), Anti-Tumor (30), Antiproliferative (30), Tumorigenic (30), arthritis (30), dementia (30), Periodontal disease (30), Cardiovascular (30), Contraceptive (30), Insulin Resistance (30), Radiosensitizer (30), Multiple myeloma (30), Cyclooxygenase Inhibitors (30). Helicobacter pylori infection (30), Myeloma (30), Cervical tumor (30), Diabetic nephropathy (29), Herpes simplex (29), Dopaminergic (29), Telomerase Inhibition (29), Cell cycle arrest (29), Serotonergic (29), pain (29), Immunomodulatory (29), Genotoxic (29), flu (29), Bladder tumor (29), Proliferative (29), Carcinogenic (29), Caspase-3 Activation (29), hepatic injury (29), Chemotherapeutic (29), Meningitis (29), Anxiety (28), Atherosclerosis (28). Uveitis (28). Parkinson's disease (28), Gastroprotective (28), Testes (28), Inflammatory Bowel Disease (28), hypothalamus (28), Chronic Renal Failure (28), cervical cancer (28), Human papillomavirus (28), COPD (28), Carcinogen (28), NF-kappaB Inhibitor (28), Hepatocellular carcinoma (27), Cataractogenic (27), cystic fibrosis (27), Sarcoma (27), Immune system (27), Chemosensitizer (27), Anti-Angiogenic (27)Small intestine (27), Antineoplastic (27), Osteoarthritis (27), Chondroprotective (26), Mesenteric Ischemia (26), Oxidants (26), Imbalance (26), Phototoxicity (26), Fever (26), chronic fatigue (26), Encephalitis (26), hepatitis (26), Hepatitis C (26), Hypoglycemic (26), Hematologic (26), Diabetic retinopathy (26), Hodgkin's lymphoma (25), Ulcerative colitis (25), anemia (25), Vitiligo (25), Uncoupling (25), Bile duct cancer (25), Parkinsonism (25), Hematopoietic (24), Atrioventricular (24), Cholinergic (24), Subarachnoid Hemorrhage (24), HIV (24), Anti-Proliferative (24), Prostatitis (24), Glycine (31), Anti-Bacterial (23), Anti-Ulcer (23), liver disease (23), Hyperthyroidism (23), Tongue (23), Hepatoprotective (23), Ewing's sarcoma (23), Stroke (23), Malaria (23), Hepatitis B (22), depression (21), Amnesia (21), Dopamine (20), pharynx (19), Leptin resistance (17)

   
  How may Curcumin work against cancer?
Studies on Curcumin and Cancer. Independent research studies on suggest that Curcumin has the potential for treatment of cancers including colon, breast, prostate, lung, skin and bowel. Curcumin is one of the most powerful and promising chemopreventive and anticancer agents, and epidemiological evidence demonstrates that people who incorporate high doses of this spice in their diets have a lower incidence of cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic investigators around the world. Because of low toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology testing and has successively made it through the first stages (Phase I) of clinical testing abroad and is currently in clinical trials at several sites in the U.S. Numerous mechanisms have been described for the anticancer activity of Curcumin. Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin has “enormous” potential to prevent and treat cancer. Curcumin was able to suppress tumor formation, growth, and even metastasis according to their review. Currently, there are clinical trials being conducted on the effects of Curcumin on patients with bowel cancer. According to the American Cancer Society, tests have shown that curcumin can kill cancer cells in laboratory dishes, and also slow the growth of the surviving cells. Furthermore, it has been found to reduce the development of several forms of cancer in lab animals, while also shrinking various animal tumors. A 2003 review - Anticancer Potential of Curcumin: Preclinical and Clinical Studies - in Anticancer Research concluded that, "…it is quite apparent that curcumin has tremendous potential for prevention and therapy of various cancers." Another study on the role of curcumin in cancer therapy found that, "Research over the last few decades has shown that curcumin is a potent anti-inflammatory agent with strong therapeutic potential against a variety of cancers. Curcumin has been shown to suppress transformation, proliferation and metastasis of tumors," and called for additional and larger controlled studies to determine its full potential. Inhibition of proliferation of tumor cells, induction of apoptosis (a mode of cell death), inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation have been linked with the activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules, inflammatory cytokines, chemokines, growth factor receptors, vascular endothelial growth factor (VEGF) and transcription factors by Curcumin have been linked to its antitumor activity. Curcumin also has been studied with regards to the core inflammatory gene signal, NF-kappaB,resulting in a beneficial domino effect throughout the body. One benefit of this domino effect is a direct reduction in the risk of cancer from overweight-induced inflammation.
 
  How may Curcumin work against arthritis and osteoathritis?
Arthritis is also a proinflammatory disease. Curcumin's anti-inflammatory properties also make it a strong candidate for treating inflammatory diseases such as osteoarthritis. A 2014 study in the Clinical Interventions in Aging found that curcumin extracts "were as effective as ibuprofen for the treatment of knee osteoarthritis." All current drugs approved for arthritis have anti-inflammatory activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production, block the action of TNF, and have activity against arthritis. When inflammation is reduced, the added benefit is pain relief. A double-blind, crossover study showed that Curcumin may be  effective in relieving pain and improvements in morning stiffness, walking time, and joint swelling.
 
  How may Curcumin work against Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved for this disease have anti-inflammatory activity. Anti-TNF therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production and the TNF action. Curcumin taken orally has been shown to have activity against inflammatory bowel disease. Study results suggest that Curcumin could have a protective role in ulcerative colitis via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and the nitrite production in colonic mucosa, reducing the development of chronic experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative Colitis.
 
  How may Curcumin work against against diabetes?
Curcumin acts directly on liver cells to help prevent them from becoming fatty, and studies have concluded that Curcumin may have an anti-diabetic effect by decreasing serum fatty acid through the promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells to help them produce insulin normally. By helping the liver and the pancreas, Curcumin is taking stress off the two most important organs whose function declines before the onset of type 2 diabetes. Curcumin also influences key hormones, supports major body organs, and regulates inflammatory signaling all in ways that help correct or prevent metabolic problems. Curcumin helps lower inappropriately high levels of leptin (reducing leptin resistance) while boosting the all-important levels of the adiponectin (which lowers insulin resistance). Curcumin also helps activate the fat-burning gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat cells. Curcumin directly reduces major inflammatory events from occurring inside white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1). By lowering such inflammation, the source of overweight-induced disease is targeted.
 
  How may Curcumin work against obesity AND metabolic syndrome?
In the prevention and treatment of obesity and metabolic syndrome, Curcumin has been reported to modulate numerous targets that have been linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues. 2) Curcumin can suppress NF-κB activation induced by a wide variety of inflammatory agents through inhibition of degradation of IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation of NF-κB, and this leads to the suppression of expression of inflammatory biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor. 4) Curcumin has been shown to downregulate the expression of various NF-κB-regulated proinflammatory adipocytokines including chemokines (such as MCP-1, MCP-4, and eotaxin) (199) and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression of plasminogen activator inhibitor type-1 through the inhibition of the transcription factor early growth response (Egr)-1 gene product that has been closely linked with insulin resistance and obesity. 5) Curcumin has been reported to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate cells. 6) Curcumin has been shown to downregulate activation of c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin pathway, which is closely linked to obesity. Later studies have indicated that Curcumin inhibits Wnt pathway signaling through downregulation of the transcription coactivator p300. Another potential mechanism by which Curcumin could inhibit β-catenin signaling is through inhibition of glycogen synthase kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin. Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32). 8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1 through the activation of Nrf2 in pancreatic cells and thus mediate the survival of these cells. 9) Curcumin downregulates the secretion of insulin-like growth factor-1 but induces the expression of insulin-like growth factor binding protein-3. 10) Curcumin interrupts leptin signaling by reducing phosphorylation levels of the leptin receptor (Ob-R) and its downstream targets. 11) Curcumin suppresses gene expression of Ob-R in HSCs. 12) Curcumin has been reported to increase the expression of adiponectin, which negatively controls obesity.
 
  How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory disease. Considerable evidence, both in animals and humans, indicates that Curcumin may be effective against psoriasis.
 
  How may Curcumin work against Alzheimer's disease and cognitive decline?
A 2008 study in the Annals of Indian Academy of Neurology explored curcumin's potential for use in the treatment for Alzheimer's disease. Some of the key points included: Curcumin may help the macrophages, which play an important role in our immune system, clear the amyloid plaques found in Alzheimer's disease. Curcumin has anti-proliferative actions on microglia. Microglia are immune cells of the central nervous system that become active in response to any number of stressors on the body. However, if the microglia have been stimulated to react too often, they become hyper-reactive, which can trigger system-wide inflammation that can be difficult to stop. Curcumin has powerful antioxidant and anti-inflammatory properties. "Overall, curcumin decreases the main chemical for inflammation and the transcription of inflammatory cytokines … The exposure to curcumin also impaired the production of pro-inflammatory cytokines (IL-1, IL-6 and TNF-)." As chronic neuro-inflammation is considered one of the major factors in the development of Alzheimer's, it's possible too that curcumin may help in the treatment of other inflammatory disorders.Researchers found that Curcumin not only reduces oxidative damage and inflammation, but also reduces amyloid accumulation and synaptic marker loss and promotes amyloid phagocytosis and clearance. Curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity in vitro, and may help the immune system clear the brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin for Alzheimer's. In the Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that reducing inflammation has positive effects on patients with Alzheimer’s. Curcumin significantly lowered several inflammation markers, in addition to reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent. "Worldwide, there are over 1000 published animal and human studies, both in vivo and in vitro in which the effects of curcumin on various diseases have been examined. Studies include epidemiological, basic and clinical research on AD." - Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. The effect of curcumin (turmeric) on Alzheimer's disease: An overview
 
  How may Curcumin work as an Anti-inflammatory?
Turmeric is safe and non-toxic and has been studied for anti-inflammatory properties, inhibiting various molecules that contribute to inflammation such as lipooxygenase, COX-2, leukotrienes, prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12).  One study compared the effectiveness of Curcumin – the active ingredient in turmeric – and a popular non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. The spice worked as well as the drug, but without the negative side effects. "Because of the crucial role of inflammation in most chronic diseases, the potential of Curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of Curcumin have been examined in animals and in humans." - Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
 
  What are the chemical properties of Curcumin?
Chemical Name Diferuloylmethane
Definition A β-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups
Systemic Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
Molecular Formula C21H20O
Molar mass 368.38 g/mol
Appearance Bright yellow-orange powder
Melting Point 183 °C, 361 °F
PubChem 969516
Biofunction Enzyme cofactor
Chemical Taxonomy Organic Chemicals / Hydrocarbons / Aromatic Compounds /  Phenols / Catechols / Curcuminoids
Chemical Structure 3D
Chemical Structure

   

Organic Source Taxonomy Kingdom
Subkingdom
Superdivision
Division
Class
Subclass
Order
Family
Genus
Species
Plantae (Plants) 
Tracheobionta (Vascular plants)
Spermatophyta  (Seed plants) 
Magnoliophyta  (Flowering plants)
Liliopsida  (Monocotyledons) 
Zingiberidae
Zingiberales
Zingiberaceae  (Ginger family) 
Curcuma (Curcuma)
Curcuma longa  (Turmeric)
 

  Why Turmeric root extract Curcumin may provide health benefits?

Certain plants manufacture chemicals that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection. In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring this evolution between plants and insects represents an important field of ecological research. Scientists have discovered that many phytochemicals manufactured in plants and roots not only prevent insect attack or fight plant infections, but also provide human health benefits. Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers. With the advent of sophisticated laboratory testing, biologists are finding that the many indigenous plants and roots from around the world provide medicinal value, and their metabolites are candidates for research. Curcumin’s structure is similar to other natural polyphenolics (chemicals containing multiple "phenol" groups) produced by plants in response to infectious attack. These natural polyphenols often have potent anti-oxidant and anti-inflammatory properties as well as immune support health benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been studied for medicinal or preventive value. Curcumin has been studied for anti-oxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities, mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered TNF blockers (humira, remicade and enbrel), vascular endothelial cell growth factor blocker (avastin), human epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib), and HER2 blocker (herceptin). Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000 papers published within the past two decades have revealed that Curcumin has extraordinary potential in promoting health through modulation of numerous molecular targets.

 

  What is the history of Curcumin and Turmeric?

Turmeric is an ancient spice and a traditional remedy. It has been used in food and as medicine for at least 4,000 years, first in India (Ayuverdic) and other parts of Asia, and later in Africa and the Caribbean. Researchers in India recently identified mineral remnants of turmeric and ginger on the cooking pots of ancient Indus River remains, one of the first urban civilizations.These ancient civilizations have vast trial and error experience with many different herbal remedies and food preparations and they selected Curcumin as a food additive and major tool for medicinal use based on efficacy. Numerous therapeutic activities have been assigned to Turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastro-intestinal systems, aches, pains, wounds  and disorders. Marco Polo, writing of his travels in China, described Turmeric in the 13th century: "There is also a vegetable which has all the properties of the true saffron, as well as the color, and yet it is not really saffron. Turmeric is held in great estimation, and being an ingredient in all their dishes, it bears, on that account, a high price."  The high degree of reverence for Turmeric is established by the fact that it is used in many cultures, each having its own name for the spice: Burmese: fa nwin. Chinese: wong geung fun, yüchiu. Danish: gurkemeje. Dutch: geelwortel. Finnish: keltajuuri. French: curcuma, saffron des Indes. German: gelbwurz, kurkuma. Icelandic: turmerik. Italian: curcuma tumeric Indian: haldee, haridra, haldi, huldee, huldie. Indonesian: kunjit, kunyit. Japanese: ukon circumin Malay: kunjit. Norwegian: gurkemeie, Polish: klacze kurkumy. Portuguese: açafrão-da-Índia. Russian: zholtymbir. Spanish: azafrán de la India, azafran arabe. Sinhalese: kaha. Swedish: gurkmeja. Tamil: munjal. Thai: ka min. Vietnamese: botnghe
 
  Why hasn't the pharmaceutical industry patented Curcumin?
Pharmaceutical corporations tried registering patents for Curcumin and Turmeric because of the much heralded scientific evidence and the long history of its healing properties. However, that same evidence and history of Curcumin being used medicinally for centuries was the reason the United States Patent and Trademark Office rejected and revoked the rights for Turmeric patent 5401504 on the grounds that the claims were not new: "USPTO unequivocally rejected all six claims made on August 13, 2001 ruling that Turmeric's medicinal properties were not patentable."  University of Texas MD Anderson Cancer Center states "in the case of Curcumin, a natural compound, no company can reap the benefits if Turmeric shows itself to be an effective anti-cancer drug." This loss to Big Pharma is a gain for educated consumers.
 
  Recent news and published studies on Curcumin and Turmeric

September  2015

5 Secret Health Benefits of Spicy Food
Desi Blitz September 2015
Curcumin in particular is said to have anti-inflammatory properties, which break down the bad brain cells linked to Alzheimer’s disease.

Turmeric Blocks Cancer Cells – Which Chemotherapy Can’t Do
Food World News September 2015
A recent study published in the Asian Pacific Journal of Cancer Prevention, for instance, found that a dose-dependent administration of curcumin effectively activated apoptosis of liver cancer cells, meaning it prompted these harmful cells to die.

How to improve your circulation
Stuff.co.nz September 2015
Ginger, similar to spicy peppers, can help blood flow, as can turmeric root, which also has anti-inflammatory properties. Turmeric contains curcumin, which is not only a wonderful antioxidant, it also assists blood flow.

Curcumin inhibits
Lab Invest. September 2015
These findings characterized a novel mechanism by which curcumin modulated hepatocyte EMT implicated in treatment of liver fibrosis

A glass of turmeric
DailyTimes.com September 2015
The major medicinal value and health benefits of turmeric are due to its main ingredient curcumin. Curcumin serves as an anti-inflammatory agent and also possess anti-bacterial and anti-viral properties. These properties make it a powerful healing agent in conditions like common cold. The anti-inflammatory action of curcumin aids in relieving the chest congestion which typically accompanies common cold. Curcumin also helps in boosting immunity and hence makes children less susceptible to such infections. When taken with milk, the absorption of curcumin in the body is enhanced significantly leading to a quick relief from common cold.

Rediscovering the Cancer-Fighting Power of Turmeric
Asbestors.com August 2015
Historical evidence dating back thousands of years shows people in China and India often used curcumin to treat a number of conditions, from coughs and colds to skin diseases and wounds. Although it's been touted for its anti-inflammatory and antioxidant properties, tests to confirm further medicinal properties over the last few decades show mixed results. But the popular spice is back in the limelight thanks to modern clinical trials evaluating the compound's cancer-fighting properties. Clinical Trials Involving Curcumin and Cancer Many studies have shown curcumin can suppress tumor cells and is safe to consume even at high doses. Researchers at Case Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus research institute in Frankfurt, Germany, published a study in September 2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue samples showed how curcumin activates the specific protein that can slow or stop the growth of mesothelioma cells.

Focus on herbs that can treat diabetes
TheHindu.com August 2015
The most active component of turmeric is curcumin, a potential therapeutic agent used in diabetes and related complications. Curcumin could alleviate most aspects of diabetes including insulin resistance, hyperglycemia, hyperlipidemia, islet apoptosis and necrosis effectively. Moreover, Curcumin is safe and relatively inexpensive.

Three reasons turmeric is a boon for diabetics
TheHealthSite.com August 2015
The antioxidant, antimicrobial, anti-inflammatory, and anti-glycaemic properties of curcumin present in turmeric, helps to strengthen the immune system and fight various infections and viruses. Here are some natural remedies that help you boost immunity and stay safe. It helps in weight management: Obesity is a major risk factor of diabetes, accumulation of abdominal fat makes insulin production difficult. However, curcumin helps to control triglyceride and cholesterol levels in the body, improve digestion, prevent the accumulation of harmful fats. This helps in weight management, an important way to manage diabetes or prevent its onset.

Top 10 super-spices
Madison.com August 2015
Curcumin is more effective slowing down the development of Alzheimer’s disease than many medications, because it decreases inflammation and oxidation in the brain. This spice also speeds up the recovery time from strokes as well. Turmeric and its active ingredient, curcumin, are also highly effective against diseases like irritable bowel disease, ulcerative colitis, Crohn’s, and arthritis. Turmeric also improves liver function, lowers homocysteine and prevents heart disease.

Curcumin shows promise for treatment of mild-to-moderate ulcerative colitis
Healio.com August 2015
“The findings of this trial suggest that curcumin as add-on therapy with optimized mesalamine is superior to optimized mesalamine alone in inducing clinical remission in patients with active mild-to-moderate UC,” the researchers concluded.

New Findings Support Curcumin as Derivative for Use in Fighting Mesothelioma
MesotheliomaHelp.com August 2105
According to researchers from Flinders Medical Centre, a teaching hospital and medical school in South Australia, curcumin, the active ingredient in turmeric and the spice that gives curry its yellow color, inhibited the growth of mesothelioma tumor cells in human patient cells. Prior research was focused on animal models. “Curcumin – which can be taken orally in tablet form – has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs,” said lead researcher and Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders, in a July 2 article in The Lead. “It may improve treatment response and allow reduction of standard drugs, improving quality of life,” added Klebe... The researchers found that the spice helps combat the cancer by directly affecting the blood supply to the tumors.

3 Reasons to Include Turmeric in Your Diet
US News & Health Report August 2015
The magic of turmeric resides in the roots, specifically in the chemical compound called curcumin. Curcumin is a polyphenol – a chemical compound found in plants with antioxidant properties and myriad therapeutic attributes. In 2007, a study in Advances in Experimental Medicines and Biology, went so far as to state that, "Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal and anticancer activities, and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses."

Turmeric Rx: Centuries-old Indian spice may have multiple health benefits
Pittsburgh Post-Gazette August 2015
Curcumin can help prevent or treat a wide spectrum of cancers, inflammatory conditions, autoimmune problems, neurological ailments including Alzheimer’s disease, cardiovascular disease, diabetes and diabetes neuropathy, among other metabolic diseases. Interest in turmeric and curcumin began decades ago when researchers began asking why India has some of the lowest rates of colorectal, prostate and lung cancer in the world, compared with the United States, whose rates are up to 13 times higher. They traced India’s advantages largely to its diet staple of curry powder, which is a combination of spices, with turmeric as a main ingredient. A recent review published in the journal Molecules said studies to date “suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.” An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that “plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.” Yet another M.D. Anderson study found that curcumin exhibits “antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities,” all bolstering its “potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease and other chronic illnesses.”

Exciting research shows curcumin spice could help treat mesothelioma
EmaxHealth.com July 2015
Curcumin is known for its anti-inflammatory and anti-cancer properties. The turmeric derivative has the ability to stop the growth of mesothelioma, found in animal lab experiments. Now researchers have taken things a step further by testing curcumin's anti-cancer effect in human mesothelioma cells Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders Medical Centre said in a media release: “Importantly, this breakthrough allows us to predict if a certain patient is likely to benefit from therapy.” Advertisement Current therapy for mesothelioma involves trying to keep the cancer from growing and spreading to other organ. Surgery is not an option for everyone. Chemotherapy has been only partially successful. Curcumin halts blood supply to mesothelioma tumors Klebe explained curcumin has the ability to stop new blood vessels from growing. Cutting off the blood supply to cancer has been a focus of treatment. But the researchers were able to show for the first time that mesothelioma cells form 3-dimensional tubes. “This may explain the poor results of trials with the standard drugs, because they do not target this type of blood vessel formation," Klebe says. The researchers thinks curcumin has a direct affect on mesothelioma tumor growth in addition to stopping blood vessels from growing. “Curcumin – which can be taken orally in tablet form - has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs. It may improve treatment response and allow reduction of standard drugs, improving quality of life,"

Treating Mesothelioma with Curcumin: Success May Be Predictable
SurvivingMesothelioma.com July 2015
Curcumin is the plant polyphenol that gives turmeric its yellow hue and spicy flavor. It has anti-inflammatory properties and has been shown to inhibit the growth of mesothelioma cells from animal models in the laboratory. Now, for the first time, researchers in Australia say they have successfully done the same thing with human cells taken from their own mesothelioma patients. Researcher Sonja Klebe, an Associate Professor at Flinders Medical Centre in South Australia where the new research was conducted, says the breakthrough will allow doctors to predict whether or not a certain mesothelioma patient will benefit from treatment with curcumin. The research at Flinders may also help explain why curcumin may sometimes work even better than traditional drugs to fight mesothelioma. Dr. Klebe says she and her research colleagues have discovered, for the first time, that mesothelioma cells may be capable of giving rise to their own blood vessels to feed growing tumors. Traditional mesothelioma medications only target blood vessel growth arising from surrounding stromal cells. “This may explain the poor results of the standard drugs because they do not target this type of blood vessel formation,” explains Dr. Klebe. Unlike these drugs, curcumin does appear to impact this type of blood vessel formation, potentially slowing or even reversing the growth of mesothelioma tumors. Curcumin can be taken in a pill form and has virtually no side effects. If the new research findings can be confirmed, Dr. Klebe says curcumin could be added to the standard treatment regimen for some mesothelioma patients, making it possible to reduce the amount of side-effect producing medications they have to take. Mesothelioma is an extremely rare and hard-to-treat cancer affecting an estimated 2,500 American patients every year. It is directly liked to asbestos exposure.

 Spicy treatment for aggressive cancer
Southern Health News, Flinders Medical Center Publication, July  2015
Scientists at Flinders Medical Centre say they have successfully used the plant polyphenol curcumin to slow the growth of mesothelioma cells taken from their own patients. To understand how this new research may impact future treatment, click here to read the article Surviving Mesothelioma has just posted. Curcumin comes from the plant that produces the spice turmeric. Although it has been used to slow the growth of mesothelioma cells taken from animal models, the new research represents the first time the same thing has been done with cells from human mesothelioma patients.

Rediscovering the Cancer-Fighting Power of Turmeric
Asbestos.com July 2015
Historical evidence dating back thousands of years shows people in China and India often used curcumin to treat a number of conditions, from coughs and colds to skin diseases and wounds. Although it's been touted for its anti-inflammatory and antioxidant properties, tests to confirm further medicinal properties over the last few decades show mixed results. But the popular spice is back in the limelight thanks to modern clinical trials evaluating the compound's cancer-fighting properties. Clinical Trials Involving Curcumin and Cancer Many studies have shown curcumin can suppress tumor cells and is safe to consume even at high doses. Researchers at Case Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus research institute in Frankfurt, Germany, published a study in September 2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue samples showed how curcumin activates the specific protein that can slow or stop the growth of mesothelioma cells. Professor of medicine at Case Western Reserve University and lead researcher of the study, Afshin Dowlati, M.D., told Asbestos.com the study "is very significant." Although the study wasn't performed on humans, Dowlati said curcumin "has shown clearly that it can reduce the cancer growth."

COX-2 inhibitors, conventional and natural, including curcumin
MyDigitalFC.com July 2015
Curcumin, the herbal aspirin, has been shown to inhibit certain growth factors. Every tumour needs blood supply and curcumin seems to impede them. Research suggests that curcumin ‘reawakens’ a key tumour-suppressor gene. It also inhibits metastases, especially in prostate and breast cancer, and quells other cancer cells, besides preventing the re-growth of cancer stem cells which populate the core of several tumours. New research hails curcumin as a ‘holistic’ anti-cancer herb, because of its success in not only halting cancer formation, replication and spread, but also providing the synergy to other anti-cancer drugs, while protecting healthy cells and organs. Research in the UK evidences that curcumin and chokeberry, for instance, can work together to induce cancer cell death (apoptosis) and prevent the spread of malignant cancer cells. Studies also suggest that curcumin can prevent cancer stem cells from re-growing the tumour. Recent research has shown curcumin can dexterously counter the dangerous effects of hormone replacement therapy (HRT) and its hazardous relationship with breast cancer. According to clinicians women could take curcumin supplements to protect themselves from developing progestin-accelerated tumours, primarily because synthetic progestin increases vascular endothelial growth factor (VEGF), a protein that helps form the blood supply to developing tumours. Curcumin inhibits VEGF and, thus, reduces the potential of breast cancer to proliferate.

Formation of Neural Tube Defects Reduced by Curcumin
EndocrinologyAdvisor.com July 2015
Curcumin appears to reduce high glucose-induced neural tube defect (NTD) formation by blocking cellular stress and activation of caspases, according to an experimental study published in the June 4 issue of the American Journal of Obstetrics & Gynecology... Under high-glucose conditions, curcumin suppressed oxidative stress in embryos. Treatment correlated with reductions in the levels of the lipid peroxidation marker, 4-hydroxynonenal, nitrotyrosine-modified protein, and lipid peroxides. In addition, curcumin blocked endoplasmic reticulum stress and abolished caspase 3 and 8 cleavage in embryos cultured under high-glucose conditions.

Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
Am J Obstet Gynecol July 2015
Curcumin reduces high glucose-induced NTD formation by blocking cellular stress and caspase activation, suggesting that curcumin supplements could reduce the negative effects of diabetes on the embryo. Further investigation will be needed to determine if the experimental findings can translate into clinical settings.

5 supplements every man should take
Curcumin has been studied as a potential cancer-fighting agent and has demonstrated an ability to reduce prostate cancer tumors. The authors of a new study in Tumour Biology, for example, reported on a mechanism by which curcumin inhibits the growth of prostate cancer cells. Curcumin also helps support prostate health in men who have prostatitis and benign prostatic hyperplasia. In addition, the compound is a potent antioxidant valued for its ability to reduce inflammation and pain in conditions such as osteoarthritis, as well as act as a blood thinner and immune-system booster. Curcumin has shown anti-diabetic effects and reduced diabetic complications.
Curcumin inhibits growth of prostate carcinoma
Tumour Biology July 2015
Prostate cancer (PC) is a prevalent cancer in aged men. Curcumin is an active ingredient that has been extracted from the rhizome of the plant Curcuma longa. Recently, a potential of Curcumin against PC has been reported in PC

West discovers health benefits of Indian spice turmeric
 A recent review published in the journal Molecules said studies to date "suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases." An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that "plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Another M.D. Anderson study found that curcumin exhibits "antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities," all bolstering its "potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses."
Molecular Modelling of Novel Potent Agents for Treating Alzheimer's Disease
Scicasts June 2015
They investigated the specific interactions between a short APP peptide and curcumin derivatives for the first time worldwide, using protein-ligand ...
Turn to turmeric for better health, experts say
Dr Joseph Maroon, the noted University of Pittsburgh Medical Centre neurosurgeon, says he uses curcumin supplements as part of his health regimen as an ultra-marathon runner. He also recommends the use of curcumin and fish oil to his patients with pain and inflammation from degenerative conditions of the spine, neck and lower back. He said 17,000 Americans die each year from over-the-counter, non-steroidal pain medications. He was lead author of a 2006 study, Natural anti-inflammatory agents for pain relief in athletes, that concludes that "Curcumin's therapeutic effects are considered comparable to pharmaceutical nonsteroidal medications ... but with a major difference in that this compound is relatively nontoxic and free of side-effects."
More turmeric
An M.D. Anderson Cancer Centre review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that "plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Yet another M.D. Anderson study found that curcumin exhibits "antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities," all bolstering its "potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses." .
Centuries-old Indian spice may have multiple health benefits
Interest in turmeric and curcumin began decades ago when researchers began asking why India has some of the lowest rates of colorectal, prostate and lung cancer in the world, compared with the United States, whose rates are up to 13 times higher. They traced India’s advantages largely to its diet staple of curry powder, which is a combination of spices, with turmeric as a main ingredient. A recent review published in the journal Molecules said studies to date “suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.”
Turmeric Rx
Hamilton Spectator June 2015
Over the centuries, the rootlike stem of the Curcuma longa plant has been used to make yellow dyes and spike food with some tasty zing. But an ever-growing mountain of evidence shows that boldly coloured turmeric with its earthy, bitter-gingery taste may offer a plethora of potential health benefits. Multiple studies — most originating in India, Europe and Australia — show that turmeric, and especially its colour-rich constituent of curcumin, can help prevent or treat a wide spectrum of cancers, inflammatory conditions, auto-immune problems, neurological ailments including Alzheimer's disease, cardiovascular disease, diabetes and diabetes neuropathy, among other metabolic diseases.
Getting to the Root of the Turmeric
In fact, one of the latest studies found that curcumin supplements (the active compound in turmeric) helped ease post-exercise muscle pain.
Research points to the health benefits of turmeric and curcumin in the diet
Multiple studies — most originating in India, Europe and Australia — show that turmeric, and especially its color-rich constituent of curcumin, can help ..
The real fountain of youth
Curcumin is currently the focus of much study for its ability to help repair DNA, especially epigenetic malfunction. Epigenetic mechanism is how the ...
Spices that prevent cancer
Curcumin: This is the king of spices when it comes to dealing with cancer diseases, besides it adding a zesty colour to our food on the platter.
The Possible Disease-Fighter in Your Spice Rack: The Many Benefits of Turmeric and Curcumin
Researchers have found that turmeric and curcumin fights the disease on a number of different levels. In a study published in the journal Clinical Cancer Research, scientists analyzed the saliva of people with head and neck cancers before and after they chewed curcumin tablets. They found that the compound suppressed two cell-signaling pathways known to stimulate the growth of these cancers.  Meanwhile, other laboratory research reveals that curcumin reduces the activity of epidermal growth factor receptors, which play a role in the spread of breast, prostate, and lung cancers. By blocking these receptors, proteins responsible for the proliferation cancerous cells aren't able to activate, thereby slowing the growth of tumors and the disease.
In a review of research published in the AAPS Journal, Jayaraj Ravindran, Ph.D., a researcher from MD Anderson Cancer Center in Houston writes, "Our review shows that curcumin can kill a wide variety of cancer cells through diverse mechanisms."  A growing stack of research indicates that curcumin can encourage apoptosis, or the death of cancerous cells, which can prevent the growth of cancerous tumors in the body. Curcumin binds to more than 30 different proteins, which may block cancer cells from transmitting factors important for their growth and activate pathways that lead to their death. What's more, Ravindran and his team identified more than 40 biomolecules involved with cell death that are influenced by curcumin.  Because curcumin fights cancer on so many different levels, it's able to outsmart the disease and prevent cancer cells from developing a resistance to treatment -- a common problem for cancer researchers. As Ravindran writes in his review, "Because of the numerous mechanisms of cell death employed by cucurmin, it is possible that cells may not develop resistance to curcumin-induced cell death."  In another review of research on curcumin, researcher Muthu K. Shanmugam, Ph.D., of the Yong Loo Lin School of Medicine at the National University of Singapore, agrees: "A plethora of in vitro and in vivo research together with clinical trials conducted over the past few decades substantiate the potential of curcumin as an anti-cancer agent ... Clinical trials with curcumin indicate safety, tolerability, non-toxicity (even up to doses of 8,000 milligrams per day), and efficacy."
Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate ...
Nature.com June 2015
We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated.
Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen ...
Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells...
Research is confirming benefits of curcumin
Among its active ingredients is curcumin, which is being actively studied for its anti-inflammatory, antioxidant, antimicrobial and cancer-fighting .
Study: Curcumin May Help Fight Oral and Cervical Cancer
According to Mishra, the natural antioxidant and the key ingredient of turmeric, curcumin, has the cancer-fighting properties. The research has claimed .
Study Finds Turmeric Can Help Treat Oral Cancers
India West May 2015
An antioxidant present in turmeric, called curcumin, has proven effective for the treatment of the human papillomavirus. (Simon A. Eugster/Wikipedia ..
Alternative Therapies to Prevent Diabetes
Newsmax May 2015
Curcumin, the substance in turmeric spice that gives Indian curry its distinctive yellow color, is an anti-inflammatory that bestows many health benefits
The Arthritis Foundation Has Identified 9 Supplements for Arthritis Symptoms
Curcumin supplements are very popular among arthritis patients. Curcumin is an active ingredient of the medicinal spice turmeric and is known for its ...
Which foods are known to reduce bowel cancer risk?
Curcumin is the substance found in turmeric that gives the spice its unmistakable yellow colour. Curcumin is a known anti-inflammatory, and it may ...
Relieve inflammation the natural way
Turmeric and curcumin supplements are available, though some healthcare experts recommend whole turmeric over the isolated form of curcumin.
Turmeric Can Fight Oral And Cervical Cancer, Says Study
The Inquisitr April 2015
According to a study published in the journal E Cancer Medical Science, an antioxidant found in turmeric called curcumin – an active ingredient in the ...
Circadian Responses to Chemo
The Scientist April 2015
Curcumin, a component of the spice turmeric, is known to have anti-cancer properties, and researchers are testing it out as a potential therapeutic ...
Cures and curcumin -- turmeric offers potential therapy for oral cancers
EurekAlert April 2015
One of the herb's key active ingredients - an antioxidant called curcumin - appears to have a quelling effect on the activity of human papillomavirus ...
Curcumin from turmeric can heal muscle injuries, reveals new study
Scientist have found that the household curry spice curcumin, a member of the ginger family can help players recover from muscle injuries and ...
Try turmeric today
TV3.ie April 2015
This is because it contains something called curcumin, which has multiple benefits. So with this in mind, we are taking a look at just some of the ways ...
Turmeric a golden addition
It is thought that the curcumin properties found in turmeric are responsible for the anti-inflammatory, anti-parasitic, anticancer and antiseptic abilities.
Curry spice to overcome aches and sore muscles
Bristol Post April 2015
Doctors based at the Olympic Training Centre, in Barcelona, Spain, have been testing a new formulation of curcumin, a member of the ginger family ...
MIND Protocol: Lifestyle Plan Beats Alzheimer's
Newsmax April 2015
"Alzheimer's is 70 percent less common in India than in the U.S., likely because of the large amounts of curcumin that are used in curries and other ...
GRAEDONS' PHARMACY
A: There are more than 7,500 scientific publications on curcumin, but much of the research for human health is still preliminary. Curcumin has been ...
The Spice That May Help Fight Breast Cancer
The Epoch Times April 2015
Exciting new research released in the journal Clinical and Experiential Medicine found that curcumin, a naturally-occurring substance found in the ...
Dietary curcumin may boost brain DHA: Study
Increased intake of curcumin could boost levels of docosahexaenoic acid (DHA) in the brain by enhancing its conversion from other omega-3 ...
One of the Best Antibiotics Could Be in Your Kitchen
Dozens of studies have revealed many clinical benefits associated with curcumin. They include antioxidant properties, anti-inflammatory activity and protection against chronic diseases such as diabetes and cancer. The molecule also has antimicrobial activity and is effective against bacteria, viruses, and even fungi. For anyone looking for an antibiotic alternative, this particular chemical is a potential golden goose.
Curcumin may be promising treatment for cancer
Curcumin, a compound found in turmeric, may be a promising treatment for a variety of cancers and other inflammatory diseases, according to an ...
The life in your spice – the health benefits of flavour
Another star in the spice rack is turmeric, which contains curcumin, a compound now being studied for its potential to prevent cancer and Alzheimer's ...
Spice Proves Effective Against Cancer
Newsmax April 2015
A new study has found that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and other ...
Curcumin proved effective at combating cancer
WA SCIENTISTS have helped re-affirm that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and ...
Topical Application of Turmeric Curcumin for Cancer
Care2.com March 2015
In my video, Turmeric Curcumin and Colon Cancer, I talked about a study where researchers showed that, by taking curcumin, the yellow pigment in
The Spice that Stops Muscle Pain in its Tracks
Care2.com March 2015
Exciting new research in the Journal of the International Society for Sports Medicine found that curcumin, one of the active ingredients in the spice ...
Turmeric Curcumin and Colon Cancer
Care2.com March 2015
The low incidence of bowel cancer in India is often attributed to natural antioxidants such as curcumin, the yellow pigment in the spice turmeric, used ...
The Spice that May Help Fight Breast Cancer
Care2.com March 2015
Both turmeric and curcumin supplements are readily available in most health food stores or from your natural health professional.
4 Natural Supplements That Are as Powerful as Drugs
EcoWatch March 2015
Garlic and curcumin are two natural supplements that boost your immune health. ... Curcumin fights inflammation at the molecular level by blocking an ...
Turmeric May Reduce Brain Damage, Ease Memories in Alzheimer's, PTSD
The substance, called curcumin, may be helpful in treating Alzheimer's disease and various psychological conditions that stem from fearful memories.
These Are The Only 3 Supplements I'll Take
Care2.com March 2015
Curcumin: About three years ago, I began to notice all the studies reporting the broad, well-documented potential of curcumin, the active ingredient
Winter Depression
Newsmax Health March 2015
A study at Baylor University found that curcumin, the main compound in the spice turmeric, worked as well as the popular antidepressant Prozac.
Aussie researchers trial turmeric for Alzheimer's
6minutes March 2015
Sydney researchers are using brain amyloid imaging to test the effects of curcumin – the active ingredient of the spice turmeric

6 foods that help fight cancer
Cosmopolitan February 2015
This popular curry spice contains an active compound called curcumin (it's what gives turmeric its bright yellow-orange colour) which has been shown to display powerful anti-cancer activity. In fact, curcumin has the most evidence-based literature supporting its use against cancer of any nutrient. Professor Bharat Aggarwal, from the MD Anderson Cancer Center in Texas goes as far as saying, "No cancer has been found, to my knowledge, which is not affected by curcumin." Pretty powerful stuff then!

Turmenic Can Erase Bad Memories And Fight Mental Disorders
Wall Street OTC February 2015
The research stated that an ingredient found in turmenic, called curcumin is involved in the process of both helping the printing of the new fears a person is dealing with and also at erasing existent negative memories. This new discovery, might come in the help of researchers for developing treatments for people suffering from mental disorders.

Turmeric: The New Superfood
Inquisitr.com February 2015
Curcumin (not related to cumin) is an antioxidant and the active ingredient in turmeric. Although it is continuously being studied, curcumin has been shown to inhibit several types of cancer cells. According to the American Cancer Society, turmeric is mostly used as an anti-inflammatory herbal remedy, with fewer side effects than common pain relievers.

Top Herbs, Latest Research
naturalproductsinsider.com February 2015
Curcumin has sparked a variety of scientific exploration into new areas, as research has recently indicated the compound can boost levels of the omega-3 docosahexaenoic acid (DHA) in the brain, where it can positively affect cognitive health. Also, drug discovery scientists have focused on novel analogs of curcumin in an effort to find compounds that have similar health benefits and overcome some of the absorption and stability challenges with the herb.

Turmeric Beneficial for Brain Health
Newswire.net February 2015
A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain.

Curcumin: This compound in turmeric can boost your heart health
TheStar.com February 2015
Adding spice – in the form of curcumin supplements – to the daily diets of people with risk factors for heart disease may lower inflammation, a new study suggests.

Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials
Sciencedirect.com February 2015
This meta-analysis showed a significant effect of curcuminoids in elevating serum SOD and catalase activities, GSH concentrations, and reduction of serum lipid peroxides.

Effect of curcumin supplementation on physiological fatigue and physical performance in mice
Nutrients. February 2015
Curcumin is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities....Curcumin supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

Turmeric Beneficial for Brain Health
NewsWire.net, February 2015
A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain

Curry spice linked to improved memory
The Guardian, February 2015
Curcumin, a bright-yellow compound found in the root of the Indian spice turmeric, prevented new fear memories being stored in the brain, and also removed pre-existing fear memories, researchers found.

Curcumin prevented new fear memories being stored in the brain and removed pre-existing fear memories
Mail Online, February 2015
Curcumin is known to have an anti-inflammatory effect on the body, and this may be how it works on fearful memories, said Professor Schafe.‘Inflammatory processes have been implicated in a wide range of diseases ranging from allergies to cardiovascular disease to Alzheimer’s,’ he said.‘Inflammation has also been implicated in psychological disorders such as depression, anxiety and post-traumatic stress disorder.‘Some of these same inflammatory pathways have also been implicated in memory formation, so it all fits.

Curcumin's ability to fight Alzheimer's studied
Science Daily, January 2015
Curcumin, a natural product found in the spice turmeric, has been used by many Asian cultures for centuries, and a new study indicates a close chemical analog of curcumin has properties that may make it useful as a treatment for the brain disease. “Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer’s with reduced toxicity,” said Wellington Pham, Ph.D., assistant professor of Radiology and Radiological Sciences and Biomedical Engineering at Vanderbilt and senior author of the study, published recently in the Journal of Alzheimer’s Disease.

The Spice Ingredient That Can Block Bad Memories
Time Magazine, January 2015
Curcumin, a compound found in turmeric that may have protective effects against neurodegenerative diseases, might one day help those with PTSD let go of bad memories, suggests a new rat study published in the journal Neuropsychopharmacology.

Reduce Heart Disease with Turmeric – It’s Just as Effective as Exercise and Cholesterol-Reducing Drug
The Raw Food World, January 2015
One study found that curcumin contains anti-thrombotic, anti-proliferative, and anti-inflammatory effects and can decrease the serum cholesterol level and protect against atherosclerosis. Several studies show the major benefit of curcumin for heart disease is improving the endothelium function in the lining of the blood vessels. Endothelium dysfunction is the main cause of heart disease and causes the endothelium to inefficiently regulate blood pressure, blood clotting, and other factors. Not only did curcumin help endothelial function, but also one study found that it’s just as effective as exercise.In addition, another study showed that it works just as well as the drug Atorvastatin. One study showed that 121 patients who underwent coronary artery bypass surgery were randomized to ingest either 4 grams of curcumin per day, a few days before and after the surgery, or a placebo. The results show that the group who ingested curcumin had a 65% decreased risk of experiencing heart attack whilst in the hospital. The authors state, “The antioxidant and anti-inflammatory effects of curcuminoids may account for their cardioprotective effects shown in this study.”

Treat Rheumatoid Arthritis with the Natural Healing Effects of Turmeric
The Raw Food World, January 2015
Curcumin is used to treat everything from skin and stomach ailments to infections and inflammations. Other research shows curcumin helps reduce Alzheimer’s. Now modern researchers have been intrigued enough to put turmeric’s many historical benefits to the test – even rheumatoid arthritis.

Turmeric associated with fewer neural tube defects in mice
2minutemedicine, January 2015
In the present work, authors investigate the impact of curcumin, a substance found in the turmeric plant, on NTDs and markers of oxidative stress in mouse embryos cultured in normal and high glucose environments. They found that embryos cultured in high glucose environments and treated with 20μM curcumin were less likely to experience oxidative stress and develop NTDs.

Curcumin in turmeric fights BP, diabetes: Study
Times of India, January 2015
The health benefits of turmeric are due to the presence of a yellow compound named curcumin. This compound is especially beneficial for fighting high blood pressure. Remarkably, this compound is not only helpful in regulating blood pressure but also effective in treating several late complications of diabetes like affecting eyes, blood vessels, kidney and brain.

A Common Kitchen Item Could Cure All Your Fears And Bad Memories
Carbonated.tv January 2015
Curcumin (a compound found in turmeric) has been found to possess the power to impair newly acquired and reactivated fear memories. The spice is vastly acknowledged for its medicinal properties, and contains anti-inflammatory bodies which are known to help with arthritis and stomach issues, among many other ailments.

Natural Interventions to Keep Your Eyesight Sharp as You Age
The Raw Food World, January 2015
 Curcumin, found in turmeric, contains a high amount of therapeutic polyphenol and is the reason for its golden color. Turns out that curcumin is able to protect against cataracts forming. (2) One study shows that curcumin had the potential to function as an anticataractogenic agent, which could possibly prevent the accumulation of calcium in the eye lens. (6) Another study showed the antioxidant effects of curcumin that appears to prevent oxidative damage and delay cataracts.

Curcumin and major depression: A randomised, double-blind, placebo-controlled trial
Neuropsychopharmacology. December 2014
Curcumin supplementation influences several biomarkers that may be associated with its antidepressant mechanisms of action. Plasma concentrations of leptin and endothelin-1 seem to have particular relevance to treatment outcome.

Curcumin inhibits proliferation of gastric cancer cells
World Journal of Surgical Oncology December 2014
Curcumin incubation significantly induced loss of MMP in SGC-7901 cells in a dose- dependent manner (P <0.05); the cell apoptotic rate also dramatically increased after curcumin incubation in a dose-dependent manner (P <0.05).

Curcumin inhibit leptin gene expression and secretion in breast cancer cells
Cancer Cell International December 2014
Curcumin inhibits the expression and secretion of leptin and it could probably be used as a drug candidate for the breast cancer therapy through the leptin targeting in the future.

Curcumin, curry are spice superstars
Harold-Review.com December 2014
More than 900 published research papers pertaining to curcumin’s anticancer activity. One of these papers found that curcumin has the ability to make some cancer cells commit suicide.

Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
Biological Research December 2014
Hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.

Curcumin and tackling mesothelioma
News Medical December 2014
As previous researchers had already demonstrated that curcumin can increase PIAS3, we used curcumin to increase the PIAS3 levels in mesothelioma cancer cells. When we exposed these cells to low levels of curcumin, we saw an increase in the intracellular levels of PIAS3. Furthermore, when we increased PIAS3, the activation of STAT3 decreased, and, in turn, the cancer cells started growing much more slowly or stopped growing altogether. So, curcumin affects mesothelioma cells by increasing the intracellular PIAS3 and therefore decreasing the STAT3 activation and cancer cell growth.

Five Benefits You Need To Know About The Ingredient That Helps Make Curry
YouthHealingMag.com December 2014
The active ingredient in turmeric is curcumin, which is known as a powerful antioxidant. This means it targets dangerous free radicals in the body and reduces the damage they are able to cause DNA and cells.A study in the Sept 2014 issue of Life Sciences performed an extensive review on curcumin and wound/injury healing. Researchers found turmeric (curcumin) to have beneficial properties that appear to speed the wound healing process. These modes of action include the modulation of inflammation and oxidation, the ability to improve granulation tissue formation, tissue remodeling, and deposition of collagen. Curcumin may be able to prevent the oxidation of cholesterol in the body. Since oxidized cholesterol is what damages blood vessels and builds up in the plaques that can lead to heart attack or stroke, preventing the oxidation of new cholesterol may help to reduce the progression of atherosclerosis and diabetic heart disease.

Unique Health Benefits Of Turmeric
Lifehacker November 2014
Curcumin, contained in turmeric, gives it powerful anti-oxidant properties, making it a strong agent against cancer. Experts say that turmeric is naturally anti-inflammatory, and while it's not a one-stop cure against the disease, it does inhibit neoplastic growth by preventing the formation of tumor blood vessels. About 30 studies exist that suggest curcumin has anti-tumor effect.

Oral curcumin shown effective in psoriasis
 Skin & Allergy News Digital Network November 2014
Studies have shown that curcumin has antiproliferative, antiangiogenic, and anti-inflammatory effects. In a small study by other investigators, topical turmeric not only successfully cleared psoriasis lesions, it also suppressed phosphorylase kinase activity, which is important to keratinocyte proliferation

How Curry Can Kill Cancer Cells
Care2.com October 2014
In cancer cells, curcumin, the pigment in the spice turmeric that makes curry powder yellow, upregulates and activates death receptors (as shown in human kidney cancer cells, skin cancer cells, and nose and throat cancer cells). Curcumin can also activate the death machine directly (as shown in lung cancer and colon cancer). Caspases are so-called “executioner enzymes,” that when activated, destroy the cancer cell from within by chopping up proteins left and right—kind of like death by a thousand cuts. And that’s just one pathway. Curcumin can also affect apoptosis in a myriad other ways, affecting a multitude of different types of cancer cells. It also tends to leave normal cells alone for reasons that are not fully understood. Overall, researchers “showed that curcumin can kill a wide variety of tumor cell types through diverse mechanisms. And because curcumin can affect numerous mechanisms of cell death at the same time, it’s possible that cancer cells may not easily develop resistance to curcumin-induced cell death like they do to most chemotherapy.”

Turmeric extract can have the potential to boost brain stem cells
TheRawFoodWorld,com October 2014
Curcumin is one of the ingredients in turmeric that exhibits over 150 potentially therapeutic activities and researchers have found it to play a significant role in improving Parkinson’s, Alzheimer’s, and stroke damage...Dr. William LaValley is one of the leading natural medicine cancer physicians. He actually devoted his time in researching the science of curcumin, which has the most evidence-based literature supporting its use against cancer of any other nutrient. He explained, “The curcumin molecule may cause either an increase in activity of a particular molecular target, or a decrease/inhibition of activity. Either way, studies repeatedly show that the end result is a potent anti-cancer activity.”

Wonder Herb
MyDigitalFC.com October 2014
Curcumin is the colouring principle of turmeric — it is the element that gives the herb its yellow hue. Aside from being the most important component of turmeric, curcumin is responsible for the herb’s anti-inflammatory effects. Research suggests that curcumin, like cayenne, another medicinal spice found in chillies, depletes substance P, the pain receptor and neurotransmitter, in the nerve endings (nociceptors). Research also suggests that curcumin and related compounds suppress pain through a mechanism similar to conventional coxib-2 inhibitors — the ‘new’ class of non-steroidal anti-inflammatory drugs (NSAIDs)...Laboratory and animal studies suggest that curcumin has the potential to prevent and treat various forms of cancer: colon, prostate, breast, and skin. As a matter of fact, there has been a substantial amount of research on turmeric’s anti-cancer potential and the results are promising. In one clinical study, researchers examined the pain-relieving properties of curcumin and/or whether it could suppress coxib-2 expression in human colon cancer cells. After exposing colon cancer cells to curcumin, they found the compound not only subdued cell growth, but also downgraded the expression of coxib-2 on the basis of a time- and dose-formatted chart. In addition, researchers observed that curcumin appeared to be a safe, natural coxib-2 inhibitor in human patients.

Carcinogen Blocking Effects of Turmeric
Care2.com October 2014
 Curcumin, present in the Indian spice turmeric, which is used in curry powder, is one such agent that is currently under clinical investigation for cancer chemoprevention.” According to their mode of action, chemopreventive agents are classified into different subgroups: antiproliferatives, antioxidants, or carcinogen-blockers. Curcumin belongs to all three, given its multiple mechanisms of action. Curcumin appears to play a role helping to block every stage of cancer transformation, proliferation, and invasion, and may even help before carcinogens even get to our cells. A study back in 1987 investigated the effects of curcumin on the mutagenicity (DNA mutating ability) of several toxins and found that curcumin was an effective antimutagen against several environmental and standard mutagenic and cancer-causing substance.

Curcumin inhibits breast cancer stem cell migration.
Stem Cell Research Therapy October 2014
Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the aggravated migration potential of breast CSCs (bCSCs), and (ii) the effects of curcumin in modulating the same...Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.

Health Benefits Of Turmeric
Huffingtonpost.com October 2014
Curcumin, the compound in turmeric responsible for that bright hue, is behind a whole host of the health benefits attributed to the spice. A 2012 study examined one perk of curcumin in particular: the ability of the extract to prevent heart attacks among bypass patients. The study followed 121 patients who had bypass surgery between 2009 and 2011. Three days before surgery through five days after, half of the patients took curcumin capsules, while the other half took placebo pills. During their post-bypass hospital stays, more people in the placebo group experienced a heart attack (30 percent) compared with those in the curcumin group (13 percent), Reuters reported. While not a substitute for medication, the researchers pointed out, the antioxidant and anti-inflammatory properties of curcumin may contribute to as much as a 65 percent lower chance of heart attack among bypass patients. ... Among people with prediabetes, curcumin capsules were found to delay the onset of Type 2 diabetes in a 2012 study. Over nine months, study participants were given either curcumin supplements or placebo capsules. Just over 16 percent of people taking the placebo pill were diagnosed with Type 2 diabetes by the end of the study, while no one taking curcumin was. Again, researchers chalk these results up to the anti-inflammatory and antioxidant powers of the compound. ... While studies in humans are still in very early stages, lab and animal studies have shown promising effects of curcumin in the fight against cancer. Curcumin "interferes with several important molecular pathways involved in cancer development, growth and spread," according to the American Cancer Society, even killing cancer cells in the lab setting and shrinking tumors and boosting the effects of chemotherapy in animals.

Turmeric enhances mood in depression research trial
Medicalxpress.com October 2014
Curcumin was significantly more effective than the placebo in improving several mood-related symptoms in the volunteers. The compound had an even greater efficacy in a small subgroup of individuals with atypical depression, which can be characterised by significant weight gain or increased appetite and hypersomnia. "In animal-based studies curcumin has been consistently shown to have antidepressant effects and it has been hypothesised that curcumin would have antidepressant effects in people with major depression," said Dr Lopresti, who is a clinical psychologist in a private practice. "There have been a few positive human-based studies investigating the effects of curcumin in depression. However, this is the first randomised, double blind, placebo-controlled study and over the longest duration.

Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
Yumanewsnow.com October 2014
The researchers treated human colon cancer tumor cells with curcumin. "We discovered that curcumin turns off the active form of cortactin," said Radhakrishnan, who led the experiments in the lab. "Thus, when cortactin is turned off, cancer cells lose the ability to move and can't metastasize to other parts of the body." More specifically, curcumin "turned off" cortactin by interacting with, and activating, an enzyme known as PTPN1. This enzyme acts as a phosphatase to remove phosphate groups from cortactin – a process known as "dephosphorylation." "This effect, essentially known as 'dephosphorylating cortactin' correlated with reduced ability of colon cancer cells to migrate," Kiela said. "This suggests that curcumin reduces cancer cells' ability to migrate, meaning the cancer can't metastasize."

Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
Biomedcentral.com October 2014
 Curcumin suppresses the expression level of FABP5 and PPARβ/δ in triple negative mammary carcinoma cells. By targeting the FABP5/PPARβ/δ pathway, curcumin prevents the delivery of retinoic acid to PPARβ/δ and suppresses retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that suppression of the FABP5/ PPARβ/δ pathway by curcumin sensitizes retinoic acid resistant triple negative breast cancer cells to retinoic acid mediated growth suppression.

Reverse Alzheimer’s, Parkinson’s and Rheumatoid Arthritis with ashwaganda, curcumin and Vitamin D
Therawfoodworld.com October 2014
It appears that ashwaganda, curcumin, Vitamin D and exercise may help the body remove amyloid protein, which is thought to cause diseases such as Alzheimer’s, Parkinson’s Disease, Rheumatoid Arthritis and several other amyloid diseases.

Oral curcumin may protect gut function
Healthcanal.com October 2014
Oral curcumin may be a viable therapy to improve intestinal barrier function changes caused by consuming a high-fat Western diet, according to a preclinical study by Virginia Commonwealth University School of Medicine researchers.

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages
Journal of Translational Medicine October 2014
Curcumin exerts well-known anti-inflammatory and antioxidant effects and probably has a protective role in the atherosclerosis.

Curcumin fights Alzheimer's disease
Foodconsumer.org October 2014
A study led by scientists at Beijing University of Chinese Medicine in Beijing, China suggests taking curcumin supplements may help prevent Alzheimer’s disease...Curcumin is an important supplement that may be used to prevent or treat cancer, inflammatory diseases, cystic fibrosis, and diabetes mellitus and many other diseases in addition to Alzheimer's disease. 

Colon cancer metastasis blocked by curcumin
Oncologynurseadvisor.com October 2014
Curcumin, derived from the spice turmeric, blocks the protein cortactin in colon cancer.

Study promotes turmeric as promising anti-cancer agent
GroundReport.com October 2014
Curcumin could provide an alternate means to the prevention of cancer. The effect of curcumin as an antioxidant, antibacterial agent and anti-tumor agent are well documented and it also has a therapeutic or preventive effect on several other diseases. The study looks at the chemopreventive effects of curcumin in cancer-prevention with specific focus on curcumin’s effect on the regulation of cell signaling and genetic pathways. Further, the study notes that turmeric and curcumin show no significant toxicity at all.

Healthy Living with Ruth Holmes: Ancient herb used as treatment
Stroud News and Journal September 2014
The bright yellow pigment contains the active compound curcumin, which is found in the roots of certain tropical plants like turmeric, and has powerful anti-inflammatory actions.  Just like the non steroidal anti inflammatory medications, it blocks the formation of the pro-inflammatory prostaglandins, and leukotrienes (also inflammatory) but does not have the side effects on the stomach that the anti-inflammatory would. as an anti-inflammatory effect on the stomach.  Curcumin is highly recommended in osteoarthritis and rheumatoid arthritis as well as post operative inflammation.  Curcumin can also be used as a poultice for inflammatory skin conditions like psoriasis and eczema, this herb will not treat any pain, as its action is to reduce and prevent further inflammation from occurring which is what causes the discomfort in the first place.

Get your glow from kitchen
Wonderwoman.intoday.in September 2014
Curcumin: An antioxidant derived from the turmeric root, its active ingredient can help calm swelling and reduce wrinkles and other signs of ageing.

Curcumin could slow down progression of lung lining cancer
Thehealthsite.com September 2014
Curcumin show promise in slowing the progression of mesothelioma, a cancer of the lung’s lining often linked to asbestos

Curcumin, The Asian Spice, Helps Fight Mesothelioma
Medicaldaily.com September 2014
Curcumin, has long been known for its cancer-inhibiting properties. But when it's combined with cancer-destroying peptides (bonded chains of amino acids), the resulting molecule promotes growth of a protein inhibitor known to combat the progression of mesothelioma.

Component in Spice May Help Slow Mesothelioma Growth
Survivingmesothelioma.com September 2014
Yet another study has demonstrated the potential mesothelioma-fighting properties of curcumin, an anti-inflammatory polyphenol that is the primary component in the spice turmeric. The latest study suggests that applying curcumin along with cancer-fighting peptides may increase the levels of a protein inhibitor that can slow the progression of mesothelioma.
October 2014

:Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
BMC Cancer September 2014
Treatment of retinoic acid resistant triple negative breast cancer cells with curcumin sensitized these cells to retinoic acid mediated growth suppression, as well as suppressed incorporation of BrdU. Further studies demonstrated that curcumin showed a marked reduction in the expression level of FABP5 and PPARbeta/delta. We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5.

Curcumin boosts testosterone level
ergo-log.com August 2014
Curcumin might be used as an alternative drug for the treatment of male infertility problems.

The new blockbuster nutrient?
Theage.com.au August 2014

Turmeric, with its active ingredient curcumin, are "blockbuster nutrients", according to professor Marc Cohen, head of Complementary Medicines at RMIT. "Turmeric is a powerful antioxidant which stops lipid oxidation and is anti-inflammatory," says Cohen, who devoted an entire chapter to turmeric in his book, Herbs and Natural Supplements: An Evidence-Based Guide. "It is a possible aid in preventing chronic degenerative diseases like Alzheimer's disease."

Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
Newindianexpress.com August 2014
Curcumin, the principal curcuminoid derived from turmeric influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal axis activity and neuroprogression, the study said. It is effective for the treatment of depressive symptoms in individuals with major depressive disorder. Curcumin is the substance in turmeric which gives the yellow color.

Eat to Beat Cancer
aarp.org August 2014
Laboratory studies have found that curcumin—the main ingredient in the spice turmeric, which gives curry its characteristic yellow color and sizzle—can fight against cancerous changes in healthy cells as well as slow the growth of malignant cells. Some evidence suggests that curcumin may also offer protection against brain tumors.

Turmeric’s Cardiovascular Benefits Found To Be As Powerful As Exercise
TheEpochTimes.com August 2014
Curcumin may prevent the age-associated decline in endothelial function in postmenopausal women
.

Powdered Gold
Cltampa.com August 2014
With more than 50 healing properties, modern research has found that the effectiveness of turmeric stems from curcumin, a natural compound it contains that is rich in antioxidants and anti-inflammatory ability. Thousands of animal and human studies have been conducted on turmeric and curcumin as both a preventive and curative agent. Current research targets curcumin’s efficacy in treating some of the world’s biggest health threats including cancer, heart disease, type 2 diabetes and Alzheimer’s disease.A number of curcumin studies have shown promising results. Curcumin can kill cancer cells in laboratory dishes and also slows the growth of the surviving cells. Curcumin has been found to reduce development of several forms of cancer in lab animals and to shrink animal tumors. On the U.S. National Library of Medicine’s website, 2,840 abstracts are listed about the study and benefits of turmeric and curcumin.

Mechanism of curcumin resistance to human cytomegalovirus in HELF cells
BMC Complementary and Alternative Medicine August 2014
Curcumin anti-HCMV effect may possibly be that curcumin concurrently alters host cell microenviroment and inhibits the HCMV antigen expressions. These findings may provide a basic understanding of the curcumin anti-HCMV effect and a novel strategy for further development of curcumin anti-HCMV treatment.

What's the one cooking trick for weight loss success?
Nola.com July 2014
Turmeric, the yellow ground spice you find in curry power, is a superspice when it comes to health and weight loss because of its active compound called curcumin. Hundreds of studies have been completed on its effectiveness against cancer, skin ailments, and lung health, just to name of few. But when it comes to the battle of the bulge, turmeric extract suppressed fat tissue growth in rodent models.

Turmeric branded latest superfood to protect against Alzheimer's
Business-Standard.com July 2014
Since inflammation is a major factor in the development of most chronic degenerative diseases including cardiovascular disease, allergies, type 2 diabetes and Alzheimer's disease, curcumin's anti-inflammatory power holds great promise in all of these conditions and many more. Murray said that the antioxidant activity of curcumin is superior to antioxidant nutrients like vitamin C and E, as they are effective against only water and fat-soluble pro-oxidants. Curcumin also helps in preventing LDL cholesterol - one of the worst kind of cholesterol - from getting oxidised and damaging arteries. and evidence is gaining that curcumin could also slow down ageing and prevent age-related diseases.

Healthiest Foods
palmbeachillustrated.com July 2014
Curcumin: An active ingredient in turmeric, this antioxidant has shown anti-cancer effects in laboratory studies and is anti-inflammatory.

Turmeric, Curcumin fights Alzheimer's disease
Foodconsumer.org July 2014
Curcumin one of the active ingredients found in turmeric has been known to protect against cancer, Alzheimer's disease, type 2 diabetes mellitus, allergies, arthritis and other chronic diseases. Epidemiological studies show that incidence of Alzheimer's disease in Southeast Asia where turmeric is commonly consumed as a spice was 4.4 times lower, compared to that found in countries where the price is not as commonly used.

Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice
Sciencedirect.com July 2014
Curcumin also reduced body weight gain and body fat without affecting fat distribution...However, at a high dose, curcumin suppressed development of steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in liver. Conclusion Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr−/− mouse model of human atherosclerosis.

5 spices to keep in your medicine cabinet
FoxNews.com July 2014
Curcumin, the active compound in turmeric, is what makes this spice so special and turmeric happens to be one of the only readily available, edible forms of it. A 2007 study also showed curcumin to have anticancer properties, with the potential to fight malignant diseases, diabetes, allergies, arthritis and Alzheimer’s disease.

Antibiotic Properties Naturally Found in the Kitchen
Globalnews.com July 2014
Curcumin. Turmeric can boost immunity, helps to maintain cholesterol levels, and can even slow the process of aging. Researchers from the University of Texas M. D. Anderson Cancer Center have attested to the benefits.

Evaluation of the Effect of Curcumin Capsules on Glyburide Therapy in Patients with Type-2 Diabetes Mellitus
Phytotherapy Research July 2014
The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control. The lipid lowering and antidiabetic properties of the curcumin show as a potential future drug molecule.

Expert touts disease-prevention benefits of Indian spices
FoxNews June 2014
Curcumin, derived from a plant that is native to the tropical southeastern Indian state of Tamil Nadu, also is used "as an adjuvant in chemotherapy, especially in breast, colon, head and neck cancer and in leukemia. Some components of curcumin are clinically shown to prevent the formation of prostate, skin and pancreas cancer cells and brain tumors.

Five Tips To Relieve Joint Pain
SMmirror.com June 2014
Curcumin, is a compound known to interfere with the chemicals that cause inflammation. Multiple clinical studies have associated curcumin with anti-inflammatory and antioxidant properties. In one study, two grams of curcumin extract provided to subjects was found to provide pain relief that was equivalent to ibuprofen for pain associated with osteoarthritis of the knee.

How What You Eat Can Help the Spinal Cord Heal Itself
V
alpolife.com June 2014
DHA and curcumin appear to invoke several molecular mechanisms that preserved neurological function in the rats. This is an exciting first step toward understanding the role that diet plays in protecting the body from degenerative disease.

Why is there Turmeric in my cereal?
BangorDailyNews.com June 2014
Curcumin is actually an antioxidant that has been shown to inhibit cancer cells in the laboratory, and curcumin slows the growth and spread of some cancers in some animal studies. Clinical trials are underway to see how it will benefit humans. Curcumin is being studied for its possible benefit for arthritis, Alzheimer’s disease and stomach ulcers as well as lowering bad cholesterol.

Turmeric: Fountain of health benefits
Greenfudge.org May 2014
Curcumin has the ability to modulate genetic activity and expression—both by destroying cancer cells and by promoting healthy cell function. It also promotes anti-angiogenesis, meaning it helps prevent the development of additional blood supply necessary for cancer cell growth. As for its effect on molecular pathways, curcumin can affect more than 100 of them, once it gets into the cell.

Boost Immunity
IrishNews.com May 2014
Curcumin, the active ingredient in turmeric. This has been found to have anti-allergy properties, which inhibit the release of histamine. Commonly used in Middle Eastern and Asian cuisine as the spice turmeric, curcumin is a phytochemical with powerful antioxidant and anti-inflammatory actions that are comparable to steroidal and nonsteroidal drugs.

Protective effect of curcumin against heavy metals-induced liver damage
Sciencedirect.com May 2014
Curcumin protects against the hepatotoxicity induced by heavy metals. • Curcumin scavenges free radicals induced by heavy metals in liver. • Curcumin’s hepatoprotective effect involves the heavy metals chelation. • Curcumin promotes liver protection by upregulating the Nrf2/Keap1/ARE pathway. • Curcumin analogues or formulations improve hepatoprotection against heavy metals.

Uncovering Hidden Secrets of an Ancient Spice
Huffingtonpost.com May 2014
Curcumin could provide antidepressant effects. Research on turmeric and diabetes also looks promising. Scientists have demonstrated that turmeric in the diet may be helpful in decreasing blood sugar. Traditional health uses of turmeric in India are to help wound healing and gastrointestinal symptoms. Now researchers from The University of Nottingham and Ludwig Maximilians University in Munich have found that curcumin may help reduce inflammation associated with tendinitis. Both turmeric and curcumin have shown potential to prevent DNA damage and help DNA repair. That is good news for preventing disease and slowing the aging process.

  • The anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
    European Journal of Nutrition School of Life Sciences, College of Natural Sciences
    Researchers reviewed the last ten years of curcumin science as it applies to supporting weight loss and preventing obesity-related disease. Their conclusion is, “The modulation of several cellular transduction pathways by curcumin has recently been extended to elucidate the molecular basis for obesity and obesity-related metabolic diseases. These findings might enable novel phytochemical treatment strategies as well as curcumin translation to the clinical practice for the treatment and prevention of obesity-related chronic diseases. Furthermore, the relatively low cost, safety and proven efficacy of curcumin make it advisable to include curcumin as part of healthy diet.”

    Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
    Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.
     

  • Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern target- Bokyung Sung 
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail.
    Spice Rack...Or Medicine Chest?
    Nutrition Action Health Letter
    "Curcumin protects the brain cells in every animal model of traumatic brain injury, whether it's stroke, Alzheimer's disease, Huntington's disease, or mad cow disease," says Gregory Cole, associate director of the Alzheimer's Disease Center at the University of California, Los Angeles. "What's unique about Curcumin," Cole notes, "is that it binds directly to beta-amyloid deposits in the brain and reduces their size." Beta-amyloid is a protein fragment that builds up between brain cells of people with Alzheimer's disease....
    Science Daily Magazine
    How Plants Protect Us From Disease
    "Everyday foods, beverages, and spices contain healthful compounds that help us fight harmful inflammation. And, in doing that, these phytochemicals may also reduce our risk of diseases associated with chronic inflammation, including cancer and diabetes."
    Curcumin Curry Power
    Science News Magazine
    "The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive."

    Health: The Fires Within
    Time Magazine
    Chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age. This concept is so intriguing because it suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three.

    Science Daily Magazine
    Did evolution give us inflammatory disease?
    Researchers demonstrate that some variants in our genes which could put a person at risk for inflammatory diseases -- such as multiple sclerosis, Crohn's disease or rheumatoid arthritis -- have been the target of natural selection over the course of human history.
    The 'inflammation theory': Immune-system errors linked to more illnesses
    The Seattle Times
    "Medical researchers are becoming increasingly convinced that the most primitive part of the immune system (inflammation), may play a crucial role in some of the most devastating afflictions of modern humans, including heart disease, cancer, diabetes and possibly Alzheimer's."

    Obesity is Inflammatory Disease, Rat Study Shows
    Sci-News.com
    "
    Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself."

    Did evolution give us inflammatory disease?
    American Journal of Human Genetics
    Researchers demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history. The findings suggest that in the past these variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely.
    Curcumin at M.D. Anderson Cancer Center
    The University of Texas, MD Anderson Cancer Center
    Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis. Epidemiological evidence indicate that incidence of certain cancers is less in people who consume Curcumin than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and anti-inflammatory effects at M. D. Anderson Cancer Center and other medical institutions.
    Curcumin Spice Healer
    Scientific American Magazine
    An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases.
    "A chapter in a forthcoming book, for instance, describes the biologically active components of Turmeric--Curcumin and related compounds called Curcuminoids--as having antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal properties, with potential activity against cancer, diabetes, arthritis, Alzheimer's disease and other chronic maladies. And in 2005 nearly 300 scientific and technical papers referenced Curcumin in the National Library of Medicine's PubMed database, compared with about 100 just five years earlier. Scientists who sometimes jokingly label themselves Curcuminologists are drawn to the compound both because of its many possible valuable effects in the body and its apparent low toxicity. They ponder how the spice or its derivatives might be used, not just as a treatment but as a low-cost preventive medication for some of the most feared ailments. As a treatment, it also has some enticing attributes. Because Curcumin targets so many biological pathways, it could have benefits for cancer therapy: malignant cells may be slow to acquire resistance to it and so might have to go through multiple mutations to avoid the substance's multipronged attack." 1 2 3 4
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      What is Turmeric-Curcumin.com?

    Turmeric-Curcumin.com is our company and website, dedicated since 2000 to offering the highest quality Curcumin 95% extract, the best customer service, the lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5 products. We remain dedicated and focused on the most powerful, healthful and important compound in botanical medicine; Curcumin, concentrated and standardized to 95% purified extract. This extraordinary spice extract has generated such interest that universities and medical centers around the world are continually conducting research studies and discovering new benefits, with multiple ongoing human clinical trials. Due to it's potent antioxidant power, Curcumin has been recognized as one of the most promising food-derived compounds in fighting a variety of degenerative diseases. The scientific evidence remains overwhelming, demonstrating the many health benefits via in vitro, in vivo and human clinical studies. You will receive 100% additive free products; no sugars or other sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums or any other unnecessary compounds. You may contact support@turmeric-curcumin.com or with any questions or comments and we will respond as quickly as possible.

     

    "Let food be thy medicine and medicine be thy food" - Hippocrates, 400 BC
    Scientia sanitas est
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