most powerful compound in botanical medicine,
the worlds most important herbal extract.
What is Turmeric and Curcumin?
Turmeric is a member of
the Curcuma botanical group, which is part of the ginger family of
herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma
longa plant is crushed and powdered into ground Turmeric. Ground Turmeric is
used worldwide as a seasoning and is the source
Curcumin is a natural component of the rhizome of Turmeric
(Curcuma longa) and one of the most studied
It is extracted, concentrated,
standardized and researched in supplement form.
direct from Turmeric-Curcumin.com, the largest supplier of
supplements at wholesale prices to the general public, research
institutions, physicians, and university medical centers for over
thirteen years. Quality control tests, laboratory analysis
certification, and rigorous
standards all ensure freshness, potency, and purity of content
material. Orders are shipped FedEx
or USPS Priority for fast and secure delivery. Contact
for bulk ordering, private
labeling or any other questions. Multiple bottle orders
will receive quantity discounts listed below, 12-bottle case purchases will also
receive free US shipping.
standardized herb extract.
Health-conscious consumers should be careful in selecting a
Curcumin extract product, making sure that they know what they’re getting.
Some buyers may have heard about Curcumin
but may not be familiar with the difference between it and Turmeric, and may
confuse the two. Our extract is standardized to contain a minimum of 95%
Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC),
Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of
76:19:5. Thus, in our
product the full
spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric
(Curcuma longa root) and represented in their
natural arrangement for maximum potency.
This is the
in clinical trials and medical studies,
free of added chemicals, 'enhancements', or treatments. Unlike
many antioxidants, Curcumin is capable of both preventing free radical
formation, as well as neutralizing existing free radicals, and is considered an
effective bioprotectant due to this dual activity. We supply the purest Curcumin
available, standardized to minimum 95% extract
milligrams per capsule.
Consumers may be misled by deceptive labels, believing there is
much more true Curcumin in a product than there really is. Some examples of these misleading claims
which make it
difficult to tell how much active Curcumin extract is actually included
mg per serving" but the serving size is 4 capsules; 500 mg "enhanced formula"
but contains only 200 mg Curcumin extract, and the remainder is 300 mg Turmeric
mg "super complex" which contains only 250 grams of Curcumin extract and the
remaining 750 grams is just Turmeric spice. The amount of
"Curcumin complex" is listed on the label rather than the amount of active
Curcumin extract. Thus,
a product labeled "1000 mg Curcumin (25%)"
does not even deliver 300 mg of Curcumin, since
averages only 3.14% Curcumin by weight.
Nutr Cancer. 55(2):126-31. These
deceptions are not uncommon in the supplement industry, even by the largest
vitamin shops. The solution is to compare; look for a label that clearly
indicates the contents (Curcumin extracted from Turmeric root), the
concentration (95%) and the amount (500mg) for each capsule, not per serving.
Our product contains 500 milligrams per capsule of 95% standardized Curcumin
extract. There is no claimed "enhancing" material to fill
the capsule up and lower the Curcumin
Our product contains no sugars or
other sweeteners, no artificial colors or flavors, no starch, no sodium, no soy,
no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper
extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa
corporation), no GMO, no dyes, no gums or any other
200 capsules per bottle.
For the environment as well as your finances, we
don't require purchasing two or three bottles to obtain 200 capsules. Each bottle
contains the full 200 capsules, with every 12-bottle case
totaling over two and a half
pounds of pure Curcumin extract. The
suggested serving size is one (1) to four (4) capsules with each meal,
preferably with beneficial oils and fats,
potentially offsetting the inflammatory response
process that occurs during ingestion and digestion.
Are there any side effects or
interactions related to
Curcumin or Turmeric?
"Curcumin, even in large quantities, does not produce any
known side effects in humans."
- Blood.101(3):1053-62. Turmeric has been used in
large quantities as a condiment for thousands of years with no adverse reactions.
The US FDA classifies Turmeric as
Recognized As Safe). Pregnant women, individuals with gallstones or using blood
thinners should consult a health care provider before using herbs or dietary
supplements in amounts greater than usually found in foods.
Has the absorption and
bioavailability of Curcumin 95% powder been studied?
Why Turmeric root extract Curcumin may provide health benefits?
Certain plants manufacture chemicals
that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of
organic compounds that deter attackers become more successful, because of their
advanced protection. In nature's never-ending interaction between predator and prey,
insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring
this evolution between plants and insects represents an important field of
ecological research. Scientists have discovered that many
in plants and roots not only prevent insect attack or fight plant infections, but also provide
human health benefits.
Many cultures create their own botanical pharmacies as
the lore of medicinal plants and remedies is handed down through generations of
healers. With the advent
of sophisticated laboratory testing, biologists are finding that the many
indigenous plants and roots from around the world provide medicinal
value, and their metabolites are candidates for research.
Curcumin’s structure is similar to other natural polyphenolics (chemicals containing
multiple "phenol" groups) produced by
plants in response to infectious attack. These natural polyphenols often have potent
anti-oxidant and anti-inflammatory properties as well as immune support health
benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from
blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been
studied for medicinal or preventive value. Curcumin has been
studied for anti-oxidant, anti-inflammatory,
antiviral, antibacterial, antifungal, and anticancer activities, mediated
through the regulation of various transcription factors, growth factors,
inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits
activities similar to recently discovered TNF blockers (humira, remicade and
enbrel), vascular endothelial cell growth factor blocker (avastin), human
epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib),
and HER2 blocker (herceptin). Considering the recent scientific bandwagon that
multi-targeted therapy is better than mono-targeted therapy for most diseases,
Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000
papers published within the past two decades have revealed that Curcumin has
extraordinary potential in promoting health through modulation of numerous molecular
What is the history of Curcumin and Turmeric?
Turmeric is an ancient spice and a traditional remedy. Its health benefits have
been described for thousands of years in
traditional Indian (Ayruvedic) and Chinese medicine largely because of its
proven efficacy in treating conditions with inflammation. These ancient
civilizations have vast trial and error experience with many different herbal
remedies and food preparations and they selected curcumin as a food additive and
major tool for medicinal use based on efficacy.
Since 1900 BC numerous therapeutic
activities have been assigned to Turmeric for a wide variety of diseases and
conditions, including those of the skin, pulmonary, and gastro-intestinal
systems, aches, pains, wounds and disorders. Marco Polo, writing of his travels in China, described
Turmeric in the 13th century: "There
is also a vegetable which has all the properties of the true saffron, as well as
the color, and yet it is not really saffron. Turmeric
is held in great estimation, and being an ingredient in all their dishes, it
bears, on that account, a high price." The high degree of reverence
established by the fact
that it is used in many cultures, each having its own name for the
geung fun, yü chiu. Danish:gurkemeje. Dutch:geelwortel.
Finnish:keltajuuri. French: curcuma, saffron des Indes.
German:gelbwurz, kurkuma. Icelandic:turmerik.
Indian:haldee, haridra, haldi, huldee, huldie.
Indonesian:kunjit, kunyit. Japanese:ukon circumin Malay:kunjit.
kurkumy. Portuguese:açafrão-da-Índia. Russian:zholty
imbir. Spanish:azafrán de la
India, azafran arabe. Sinhalese:kaha. Swedish:gurkmeja.
Tamil:munjal. Thai:ka min. Vietnamese:bot
the pharmaceutical industry patented Curcumin?
on Curcumin and Cancer. Independent research studies on suggest that Curcumin has the potential for
treatment of cancers including colon, breast, prostate, lung, skin and bowel.
Curcumin is one of the most powerful and promising chemopreventive and
anticancer agents, and epidemiological evidence demonstrates that people who
incorporate high doses of this spice in their diets have a lower incidence of
cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic
investigators around the world. Because of low
toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology
testing and has successively made it through the first stages (Phase I) of
clinical testing abroad and is currently in clinical trials at several sites in
the U.S. Numerous mechanisms have been
described for the anticancer activity of Curcumin. Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin
has “enormous” potential to prevent and treat cancer. Curcumin was able to
suppress tumor formation, growth, and even metastasis according to their review.
Currently, there are clinical trials being conducted on the effects of Curcumin
on patients with bowel cancer. Inhibition of proliferation
of tumor cells, induction of apoptosis (a mode of cell death), inhibition of
transformation of cells from normal to tumor, inhibition of invasion and
metastasis and suppression of inflammation have been linked with the
activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules,
inflammatory cytokines, chemokines, growth factor receptors, vascular
endothelial growth factor (VEGF) and transcription factors by Curcumin have been
linked to its antitumor activity. Curcumin also has been studied with
the core inflammatory gene signal, NF-kappaB,
resulting in a beneficial domino effect throughout the body. One benefit of this
domino effect is a direct reduction in the risk of cancer from
How may Curcumin work against
Arthritis is also a proinflammatory
disease. All current drugs approved for arthritis have anti-inflammatory
activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this
disease. Curcumin has been shown to both suppress the TNF production, block
the action of TNF, and have
activity against arthritis.
When inflammation is reduced, the added benefit is
pain relief. A double-blind, crossover study showed that Curcumin may be effective
in relieving pain and improvements in morning stiffness, walking time, and joint
How may Curcumin work against
Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved
for this disease have anti-inflammatory activity. Anti-TNF therapy has been
approved for this disease. Curcumin has been shown to both suppress the TNF
production and the TNF action. Curcumin taken orally has been shown to have
activity against inflammatory bowel disease. Study results
suggest that Curcumin could have a protective role in ulcerative colitis via
regulation of oxidant/anti-oxidant balance and modulation of the release of some
inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced
colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK
signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and
the nitrite production in colonic mucosa, reducing the development of chronic
experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative
How may Curcumin work against
Curcumin acts directly on liver cells to help
prevent them from becoming fatty, and studies have concluded that Curcumin may
have an anti-diabetic effect by decreasing serum fatty acid through the
promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells
to help them produce insulin normally. By helping the liver and the pancreas,
Curcumin is taking stress off the two most important organs whose function
declines before the onset of type 2 diabetes. Curcumin also influences key
hormones, supports major body organs, and regulates inflammatory signaling all
in ways that help correct or prevent metabolic problems. Curcumin helps lower
inappropriately high levels of leptin (reducing leptin resistance) while
boosting the all-important levels of the adiponectin
(which lowers insulin resistance). Curcumin also helps activate the fat-burning
gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat
cells. Curcumin directly reduces major inflammatory events from occurring inside
white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte
chemotactic protein-1). By lowering such inflammation, the source of
overweight-induced disease is targeted.
How may Curcumin work against obesity AND metabolic syndrome?
In the prevention and treatment of obesity and metabolic
syndrome, Curcumin has been reported to modulate numerous targets that have been
linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues.
2) Curcumin can suppress NF-κB activation induced
by a wide variety of inflammatory agents through inhibition of degradation of
IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation
of NF-κB, and this leads to the suppression of expression of inflammatory
biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth
factor. 4) Curcumin has been shown to downregulate the expression of
various NF-κB-regulated proinflammatory adipocytokines including chemokines
(such as MCP-1, MCP-4, and eotaxin) (199)
and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression
of plasminogen activator inhibitor type-1 through the inhibition of the
transcription factor early growth response (Egr)-1 gene product that has been
closely linked with insulin resistance and obesity. 5) Curcumin has been reported
to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate
cells. 6) Curcumin has been shown to downregulate activation of
c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin
pathway, which is closely linked to obesity. Later studies have indicated that
Curcumin inhibits Wnt pathway signaling through downregulation of the
transcription coactivator p300. Another potential mechanism by which Curcumin
could inhibit β-catenin signaling is through inhibition of glycogen synthase
kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin.
Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32).
8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1
through the activation of Nrf2 in pancreatic cells and thus mediate the survival
of these cells. 9) Curcumin downregulates the secretion of insulin-like growth
factor-1 but induces the expression of insulin-like growth factor binding
protein-3. 10) Curcumin interrupts leptin signaling
by reducing phosphorylation levels of the leptin receptor (Ob-R) and its
downstream targets. 11) Curcumin suppresses gene expression of Ob-R in
HSCs. 12) Curcumin has been reported to increase the expression of
adiponectin, which negatively controls obesity.
How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory
disease. Considerable evidence, both in animals and humans, indicates that Curcumin
may be effective against psoriasis.
How may Curcumin work against Alzheimer's
Researchers found that Curcumin
not only reduces oxidative damage and inflammation, but also
reduces amyloid accumulation and synaptic marker loss and promotes amyloid
phagocytosis and clearance. Curcumin worked to prevent synaptic marker and
cognitive deficits caused by amyloid peptide infusion and abeta oligomer
toxicity in vitro, and may help the immune system clear the
brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin
for Alzheimer's. In the
Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that
reducing inflammation has positive effects on patients with Alzheimer’s.
Curcumin significantly lowered several inflammation markers, in addition to
reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent.
How may Curcumin work
as an Anti-inflammatory?
Turmeric is safe and non-toxic and
has been studied for anti-inflammatory properties, inhibiting various molecules that
contribute to inflammation such as lipooxygenase, COX-2, leukotrienes,
prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis
factor (TNF), and interleukin-12 (IL-12). One study compared the
effectiveness of Curcumin – the active ingredient in turmeric – and a popular
non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end
of the six days, those taking the Curcumin and the NSAID enjoyed a significantly
better anti-inflammatory response than placebo. The spice worked as well as the
drug, but without the negative side effects.
Recent news and published studies on Curcumin and Turmeric
News.am February 2014
A study at Baylor University found that curcumin, the main compound in the spice
turmeric, worked as well as the popular antidepressant Prozac. Study
participants were divided into three groups: one took 500 milligrams of curcumin
twice a day; the second took a standard dose of Prozac, and the third group took
a combination of both. After six weeks, curcumin relieved symptoms of depression
as effectively as Prozac.
Atlantablackstar.com February 2014
Curcumin is a natural carotenoid and polyphenol which may be isolated from
Curcuma longa or turmeric, a rhizome. Owing to their structure, carotenoids are
scavengers of free radicals, which make them great anti-oxidants and boosters of
the immune system of vertebrates, humans included. Curcumin is also an effective
antibacterial agent and anti-carcinogenic. Studies have demonstrated that
curcumin inhibits the growth of a number of tumors when used in combination with
radiation therapy. In prostate cancer, curcumin overcomes the effect of
prosurvival gene expression induced by the exposure of cancer cells to
WorldBulletin.com February 2014
The curcumin diet significantly reduced bile duct blockage and curbed liver cell
damage and scarring by interfering with chemical signalling pathways involved in
Cancer Prev Res (Phila).
Curcumin, the primary component in the dietary spice turmeric, may be a powerful
ally in the
fight against malignant mesothelioma. The new study, published in the
journal Cancer Prevention Research, finds that curcumin may both attack existing
mesothelioma cells and protect against the development of new ones. Curcumin is
a polyphenol with anti-inflammatory properties. Numerous studies have confirmed
its ability to help fight cancer, including mesothelioma. In the newest study, a
team at the University of Vermont tested curcumin on
human mesothelioma cell lines as well as cells derived from infected mice.
TwoCircles.net January 2014
Curcumin has been shown to be particularly beneficial in this aspect. "These
phytochemicals showed their efficiency to counter DNA damage caused by arsenic.
This DNA damage initiates the process of cancer development; therefore reduction
of such damage may pave a way to cancer prevention. Apart from this,
phytochemicals also play a role in repair of DNA damage. We conducted a field
study where curcumin has been found to be of great value in combating the
problem with arsenic at the genetic level."
Huffington Post December 2013
Take advantage of curcumin (the substance that gives turmeric it's bright yellow
colour) because it can dramatically improve your health. The anti-inflammatory
and antioxidant powers of curcumin prevent and fight a wide variety of
conditions ranging from sleep deprivation to stress, and beyond.
The Financial Express January 2014
The benefits for heart health arise from curcumin, an active principle which is
anti-oxidant, anti-clotting, anti-inflammatory and anti-proliferative. Several
scientific studies have documented the effect of curcumin in decreasing blood
cholesterol levels. Anti-oxidant properties of curcumin may also help prevent
cardiovascular complications among diabetics.
BMC Complement Altern Med. 2013 Dec 24
The administration of curcumin to diabetic rats normalized significantly their
blood sugar level and TBARS values and increased the activities of all
antioxidant enzymes and reduced glutathione concentration.
World Journal of Gastroenterology December 2013 Curcumin shows enhanced cytotoxicity toward
PTEN-deficient cancer cells, suggesting that it might be a potential
chemotherapeutic agent for cancers harboring PTEN mutations
Atlanta Blackstar, December 2013
Researchers found 26 percent fewer fatty artery deposits in the mice fed the
curcumin-enhanced diet. Fewer atherosclerotic lesions were seen in these mice.
In addition, the researchers found that curcumin seemed to actually change the
expression of genes related to plaque buildup in arteries...After 18 weeks, the
researchers found that just like lovastatin, curcumin lowered blood levels of
cholesterol, triglycerides and LDL cholesterol, while increasing levels of HDL
(“good”) cholesterol. It also led to changes in gene expression that could be
expected to reduce the risk of artery damage and heart disease.“Long-term
curcumin treatment lowers plasma and hepatic cholesterol and suppresses early
atherosclerotic lesions comparable to the protective effects of lovastatin,” the
researchers concluded. “The anti-atherogenic effect of curcumin is mediated via
multiple mechanisms including altered lipid, cholesterol and immune gene
FoodConsumer.org December 2013
Curcumin has already been known to prevent obesity and diabetes mellitus in
animal studies and human trials...Curcumin was found to suppress oleic acid
induced lipid accumulation and lower triglycerides and total cholesterol
levels...."These results indicated that curcumin has the same ability to
activate AMPK and then reduce SREBP-1, and FAS expression, finally leading
to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this
report, we found curcumin exerted a regulatory effect on lipid accumulation
by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be
active in the prevention of fatty liver."
NaturalNews.com December 2013
Cancer cell death was observed through curcumin’s ability to reduce
pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a
time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells
to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks. The
researchers were so astounded that they proposed that curcumin may actually have
therapeutic potential in the management of colon cancer.
HeatlhNewsDigest.com Curcumin is found in
the spice turmeric, the main spice used to prepare curry. Curcumin is thought to
have antioxidant properties, as it may decrease swelling and inflammation.
Preliminary research suggests that curcumin may prevent cancer and possibly slow
the spread of cancer.
HispanicBusiness.com December 2013
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that
enters into the composition of curry, already described for its diverse and
broad biological activities, is nowadays well described as an inhibitor of DNA
methyltransferase so that it is considered as a DNA hypomethylating agent...This
dietary compound is able to restore the epigenetic regulation balance and
appears as an attractive preventive and/or therapeutic approach against human
utSanDiego.com November 2013
Some research found that curcumin may help clear the amyloid plaques found in
Alzheimer's disease. Other studies documented curcumin as a powerful
anti-inflammatory that may have a role in the cure of Alzheimer’s. Some research
has found curcumin to be a robust antioxidant, which helps ease Alzheimer's
symptoms caused by oxidation and inflammation.
Foodconsumer.org November 2013
H.M. Maier from The Florida State University in Tallahassee, Florida, USA and
colleagues reviewed studies and found evidence from animal studies indicating
that curcumin, L-arginine and vitamin E as dietary supplements can help wound
healing in people with type 2 diabetes mellitus.
ProHealth.com October 2013
Turmeric is one the most thoroughly researched plants in existence today. Its
medicinal properties and components (primarily curcumin) have been the subject
of over 5600 peer-reviewed and published biomedical studies. In fact, our
five-year long research project on this sacred plant has revealed over 600
potential preventive and therapeutic applications, as well as 175 distinct
beneficial physiological effects.
FoxNews.com October 2013
The compound curcumin is found in turmeric, a spice commonly used in the Indian
curry. It’s packed with antioxidants, which help reduce inflammation and free
radicals in the body, and now it may help to ease depression symptoms as well.
Foodconsumer.org October 2013
Curcumin has been known to have protective effects against cancer and type 2
diabetes mellitus. It should not be a surprise that curcumin has antidiabetic
and anticancer bioactivities because it is a polyphenol that may render the
protection as an antioxidant against a range of disease-associated medical
conditions including tumorigenesis, oxidation, inflammation, apoptosis and
hyperlipemia. In addition to Alzheimer's disease and diabetes, taking curcumin
dietary supplements may help prevent or treat multiple myeloma, pancreatic
cancer, myelodysplastic syndromes, colon cancer, and psoriasis, according to
Forbes.com October 2013
Turmeric, the spice that gives curry and mustard their yellow color,
contains a chemical called curcumin that’s the subject of numerous
neurologic studies right now. Research has shown curcumin’s ability to boost
the progression of Alzheimer’s and stimulate neurogenesis, which is the
process of creating new brain cells. Studies suggest curcumin may also clear
out amyloid plaques, the brain gunk thought to be a cause of Alzheimer’s,
and calm inflammation of brain and nerve cells.
When the researchers administered daily oral
of 80 mg for three days, significant changes occurred. The mercury induced
serum biochemical changes were reversed, as the liver and kidneys began
showing signs of repair.
Spice in Your Life
DocGiff.com October 5, 2013
Researchers have tested this spice as a cure for cancer and Alzheimer’s disease.
It’s actually the cause of the yellow color, curcumin in turmeric, which
interests scientists. Dr. Bharat Aggarwal, professor of cancer research at the
Anderson Cancer Center in Houston, said curcumin induced a programmed death of
cancer cells. In addition, it suppressed formation of new blood vessels that
nourished tumors. Rats, for instance, got fewer cancers of the breast and colon
when given curcumin.Researchers at Harvard went a step further and injected
curcumin into the bloodstream of mice with Alzheimer disease-like plaques. A
week later, studies showed a 30 percent decrease in these plaques. Research into
how this spice affects humans with Alzheimer’s disease is only in preliminary
No cure for Alzheimer’s disease, but curcumin may help
Foodconsumer.org October 2013 Epidemiological studies have shown that people
who eat a diet high in curcumin were at a lower risk of Alzheimer's disease,
suggesting that taking curcumin supplements may help prevent the disease. Indian
studies have already suggested that a high dose of curcumin like 6 grams of
curcumin per day can be used to prevent type 2 diabetes mellitus in people
living with prediabetes. Curcumin as an antioxidant has an antiinflammatory
effect and may potentially help prevent a variety of cancer.
Suppository of wisdom
Journal of Crohn's and Colitis October 2013
Curcumin enemas may be effective in controlling disease activity in ulcerative
ThirdAge.com September 2013
Canadian researchers reported that curcumin, found naturally in the spice
turmeric, may have “antitumor activity” and “continues to receive considerable
attention as a potent antioxidant and anti-cancer agent”. According to the Mayo
Clinic, “At this time, there isn't enough evidence to recommend curcumin for
preventing or treating cancer, but research is ongoing. Curcumin, a substance
found in the spice turmeric, has long been used in Asian medicine to treat a
variety of maladies. Now some research suggests that curcumin may help prevent
or treat cancer.
FoxNews.com Chris Kilham Medicine Hunter,
September 01, 2013
Turmeric root This yellow root contains a profoundly beneficial compound called
curcumin that possesses superior anti-inflammatory activity, aids the immune
system, enhances the brain, and protects your skin. Curcumin from turmeric is a
very popular anti-inflammatory remedy. You can sprinkle turmeric on food, cook
with it, or use curcumin supplements.
Korean J Physiol Pharmacol.
2013 August Curcumin (diferuloylmethane), a polyphenol derived from the plant
turmeric (Curcuma longa Linn), is known for its antioxidant and
anti-inflammatory properties. Moreover, quite a few studies, including our own,
have shown that curcumin exhibits anticancer activities against various tumors,
including pancreatic, colon, ovarian, and breast cancers, by modulating multiple
signaling pathways. Curcumin has been reported to increase p53 signaling, which
upregulates the transcription of downstream genes such as p21 and Bax to induce
apoptosis in a variety of cancer cells. In addition, curcumin causes cancer cell
apoptosis, in part via suppression of Notch1 signaling.
Dallas News, August 4, 2013
Curcumin can aid in many illnesses associated with inflammation, from cancer to
arthritis, and even Alzheimer’s disease. Now he has a study, published in July’s
Phytotherapy Research, that suggests curcumin is just as effective as Prozac, an
anti-depressant fluoxetine, in treating clinical depression.
Complementary and Alternative Medicine 1 August 2013
Curcumin was found to ameliorate the abnormalities in the behavior and brain
glucose metabolism caused by CUS, which may account for its antidepressive
Many studies now prove that turmeric/curcumin contain over 150 potentially
therapeutic traits, which include antioxidant, anti-inflammatory and anti-cancer
properties. Remarkably, curcumin is capable of crossing the blood-brain barrier,
which is one reason why it holds promise as a neuroprotective agent in a wide
range of neurological disorders. Researchers have investigated curcumin for its
potential role in improving Parkinson’s disease as well. Studies have shown
that it may even hold more promise than the drugs currently used for this
The many healing properties of curcumin are some of the most exciting
discoveries in the field of functional medicine. Curcumin counters inflammation,
detoxifies excess estrogen, supports the body’s antioxidant system, helps deal
with abnormal blood fat ratios (dyslipidemia) and offers protection against
colds and flu.
eMaxHealth-by Kathleen Blanchard-Jul 14, 2013
Health benefits of curcumin in the spice turmeric include, but may not be
limited to the following, based on research studies.Liver
health, Heart health, Pain relief,
Colon cancer, Breast cancer
prevention, Alzheimer’s disease, Obesity, Dental health, Acne,
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that
enters into the composition of curry, already described for its diverse and
broad biological activities...is able to restore the epigenetic regulation
balance and appears as an attractive preventive and/or therapeutic approach
against human cancer.
Gut 2013 June
Curcumin is a pan-antioxidant with anti-inflammatory, anti-apoptotic,
anti-microbial, and anti-fibrogenic properties...This study postulates the
effects of Curcumin plus vitamin E in NAFLD may prevent NASH with a modest anti-fibrotic
effects and necroinflammatory score; with impressive changes in adipokines
levels. Additive effects of Curcumin with vitamin E has significant effects on
Serum lipids and insulin sensitivity. Unavailability of Pre and post liver
biopsy was the limitation A large control trial needs to validate..
Phytomedicine 2013 June
Curcumin, a natural polyphenolic flavonoid isolated from the rhizome of a plant,
Curcuma longa Linné., has been found to possess many beneficial biological
activities. The aim of this study was to investigate the synergistic effect of
curcumin and antibiotics as well as to determine the antibacterial activity of
Curcumin against specific MRSA strains.
Curcumin, a polyphenolic compound
isolated from Curcuma longa (Turmeric) is widely used in traditional Ayurvedic
medicine. Its potential therapeutic effects on a variety of diseases have long
been known. Though anti-tumour effects of curcumin have been reported earlier,
its mode of action and telomerase inhibitory effects are not clearly determined
in brain tumour cells. In the present study, we demonstrate that curcumin binds
to cell surface membrane and infiltrates into cytoplasm to initiate apoptotic
Food Consumer 2013 May
Curcumin an ingredient found in turmeric has been used to prevent many chronic
diseases including obesity, type type 2 diabetes and liver disease. Recent
studies show that this dietary supplement possesses potent antioxidant,
anticarcinogenic, antiinflammatory and hypoglycemic properties.
Food Funct. 2013 April
This study provides compelling evidence of the pharmacodynamic additive effect
of limonoids and curcumin in inhibiting human colon cancer cells. These results
suggest that consumption of curcumin and limonoids together may offer greater
protection against colon cancer.
CNS Neurol Disord Drug Targets. 2013 April
Curcumin, the major constituent of the spice turmeric produces a plethora of
biological actions that have translated in vivo into behavioral and
neurochemical effects in rodents that are also produced by clinically-used
Pharmacol Toxicol. 2013 April
Curcumin is a well-known component of traditional turmeric (Curcuma longa),
which has been reported to prevent obesity and diabetes. The levels of total
cholesterol, fasting glucose and insulin in serum were decreased, and HFD-induced
impairment of insulin sensitivity was improved by curcumin supplementation
Exp Dermatol. 2013 April
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma
longa), which is commonly used as a spice. Recent studies have shown that
curcumin has a wide range of pharmacological activities, including
anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic
activities.... Curcumin prevented UVB-induced MMP expression
Biogerontology. 2013 April
Curcumin is the active component of curcuma longa and has shown antioxidant,
antiinflamatory and neuroprotective properties...curcumin supplementation
improves cognitive functions by decreasing the lipid peroxidation in brain
tissue of aged female rats.
Curr Med Chem. 2013 April
Curcumin is the major yellow pigment extracted from turmeric, a commonly used
spice in Asian cuisine that is used extensively in ayurvedic herbal remedies. A
number of studies have shown that curcumin can be a prevention agent and a
chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is
also well-known for its anti-inflammatory and antioxidant properties, showing
high reactivity towards peroxyl radicals, and thus acting as a free radical
Curr Cancer Drug Targets. 2013 April
Accumulating evidence has demonstrated that some common natural products (such
as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN)
and resveratrol) have anticancer properties through the mechanisms of altering
epigenetic processes and targeting cancer stem cells (CSCs). These bioactive
compounds are able to revert epigenetic alterations in a variety of cancers in
vitro and in vivo. They exert the anticancer effects by targeting various
signaling pathways related to the initiation, progression and metastasis of
cancer. It appears that natural products hold great promise for cancer
prevention and treatment by altering various epigenetic modifications.
Mol Cell Biochem. 2013 April
Curcumin, a phytochemical, has a wide variety of biological actions including
anti-inflammatory and antioxidative....the formation of protein carbonyls in the
liver of the aging mice can be prevented by the antioxidative effects of
melatonin and curcumin, which may provide health benefits in aging animals.
Food Chem. 2013 April
Curcumin, the active constituent of dietary spice turmeric, possesses a strong
potential for cancer prevention and treatment...The findings showed that
curcumin might be an effective tumouristatic agent for the treatment of
aggressive papillary thyroid carcinomas.
PLoS One. 2013 April
Curcumin administration significantly reduced infarct size. Curcumin also
markedly reduced oxidative stress levels in middle cerebral artery occlusion (MCAO)
rats; Taken together, these findings provide evidence that curcumin protects
neurons against ischemic injury, and this neuroprotective effect involves the
Akt/Nrf2 pathway. In addition, Nrf2 is involved in the neuroprotective effects
of curcumin against oxidative damage.
Curcumin Controls Blood Sugar: It switches on the liver genes that
keep glucose levels in check. It improves the pancreas’s ability to
make insulin and helps slow down the metabolism of carbohydrates
after meals. Curcumin Fights Cancer: It inhibits the genetic switches
that allow for cancerous cell growth to occur. Curcumin Speeds Up
Metabolism: USDA research shows that is enhances cellular energy to
speed metabolism. Curcumin Clears Plaque: It removes amyloyd plaque
buildup in the brain that can cause Alzheimer’s.
active ingredient of turmeric, is proved to be a potential
candidate of controlling inflammation and bone resorption
(and) may decrease alveolar bone loss in the experimental
periodontitis rats via suppressing the expression of RANKL/RANK/OPG
and its anti-inflammatory properties.
Curcumins, derived from the spice turmeric, and
resveratrol, polyphenols found in grapes and red wine
respectively, in addition to their antioxidant and
anti-inflammatory properties, inhibit preadipocyte
proliferation, de novo lipogenesis and fat accumulation in
liver....The therapeutic use of
and resveratrol, in the context of obesity as an initiator of
insulin resistance and hypertension, the two main features of
MS, together with the underlying mechanisms of action.
Curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC)
have been demonstrated as having antioxidant, anticarcinogenic, and
hypocholesterolemic activities. We report the diverse
antiatherogenic effects and mechanisms of curcuminoids. Curcumin
was the most potent antioxidant.
Curcumin is known to have antioxidant and
anti-inflammatory properties. Curcumin
treatment improved gastric emptying by blocking the production
of oxidative stress, abolishing NF-kappaB signal transduction
and enhancing expression of SCF/c-kit in rats with diabetic
Curcumin is a known cytoprotectant with
comprehensive anti-inflammatory and anti-cancerous
properties...Curcumin should be investigated as a potential safe
and remarkable approach in attenuating the adverse effects
induced by CP-related toxicants.
J Neuroimmune Pharmacol.
Curcumin could be a candidate neuroprotective agent by
inducing macroautophagy, and needs to be further investigated by
clinical application in patients suffering Parkinson's disease.
Curcumin is known to have antioxidant
and anti-inflammatory properties. Curcumin treatment improved
gastric emptying by blocking the production of oxidative stress,
abolishing NF-kappaB signal transduction and enhancing expression of
SCF/c-kit in rats with diabetic gastroparesis.
anti-inflammatory role of curcumin in obesity and obesity-related
Eur J Nutr. 2011 Apr;50(3):151-61. Epub 2011 School of Life Sciences, College of Natural
Sciences Researchers reviewed the last
ten years of curcumin science as it applies to supporting weight
loss and preventing obesity-related disease. Their conclusion is, “The
modulation of several cellular transduction pathways by curcumin has
recently been extended to elucidate the molecular basis for obesity and
obesity-related metabolic diseases. These findings might enable novel
phytochemical treatment strategies as well as curcumin translation to
the clinical practice for the treatment and prevention of
obesity-related chronic diseases. Furthermore, the relatively low cost,
safety and proven efficacy of curcumin make it advisable to include
curcumin as part of healthy diet.”
Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and
Cytokine Research Laboratory, Department of Experimental
Therapeutics, The University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030 Extensive research within the past two decades has revealed that obesity,
a major risk factor for type 2 diabetes, atherosclerosis, cancer,
and other chronic diseases, is a proinflammatory disease. Several
spices have been shown to exhibit activity against obesity through
antioxidant and anti-inflammatory mechanisms. Among them, curcumin,
a yellow pigment derived from the spice turmeric (an essential
component of curry powder), has been investigated most extensively
as a treatment for obesity and obesity-related metabolic diseases.
Curcumin directly interacts with adipocytes, pancreatic cells,
hepatic stellate cells, macrophages, and muscle cells. There, it
suppresses the proinflammatory transcription factors nuclear
factor-kappa B, signal transducer and activators of transcription-3,
and Wnt/β-catenin, and it activates peroxisome proliferator-activated
receptor-γ and Nrf2 cell-signaling pathways, thus leading to the
downregulation of adipokines, including tumor necrosis factor,
interleukin-6, resistin, leptin, and monocyte chemotactic protein-1,
and the upregulation of adiponectin and other gene products. These
curcumin-induced alterations reverse insulin resistance,
hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.
Pharmacological basis for the role of curcumin in chronic
diseases: an age-old spice with modern target- Bokyung Sung
Cytokine Research Laboratory, Department
of Experimental Therapeutics, University of Texas M. D. Anderson
Cancer Center, Houston, TX 77030, USA Curcumin (diferuloylmethane),
a yellow pigment in the spice turmeric (also called curry
powder), has been used for centuries as a treatment for
inflammatory diseases. Extensive research within the past two
decades has shown that curcumin mediates its anti-inflammatory
effects through the downregulation of inflammatory transcription
factors (such as nuclear factor κB), enzymes (such as
cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as
tumor necrosis factor, interleukin 1 and interleukin 6). Because
of the crucial role of inflammation in most chronic diseases,
the potential of curcumin has been examined in neoplastic,
neurological, cardiovascular, pulmonary and metabolic diseases.
The pharmacodynamics and pharmacokinetics of curcumin have been
examined in animals and in humans. Various pharmacological
aspects of curcumin in vitro and in vivo
are discussed in detail.Trends
Pharmacol Sci. 2009 Feb;30(2):85-94. Epub 2008 Dec 26
Rack...Or Medicine Chest?
Nutrition Action Health Letter "Curcumin protects the brain cells in every animal model of
traumatic brain injury, whether it's stroke, Alzheimer's disease,
Huntington's disease, or mad cow disease," says Gregory Cole,
associate director of the Alzheimer's Disease Center at the University
of California, Los Angeles. "What's unique about Curcumin,"
Cole notes, "is that it binds directly to beta-amyloid deposits in
the brain and reduces their size." Beta-amyloid is a protein
fragment that builds up between brain cells of people with Alzheimer's
News Magazine "The list of Curcumin's effects goes on and on, and they're all in
your favor...in addition to its anti-inflammatory and antioxidant
properties, Curcumin has several effects that may work in tandem to
protect the brain from plaques in other ways. "If Curcumin had a
single molecular target, it probably would not be as good a drug,"
M.D. Anderson Cancer
Center in Houston. "But because it has multiple targets, it's very
Health: The Fires Within
Chronic inflammation may be the engine that drives many of the most
feared illnesses of middle and old age. This concept is so intriguing
because it suggests a new and possibly much simpler way of warding off
disease. Instead of different treatments for, say, heart disease,
Alzheimer's and colon cancer, there might be a single,
inflammation-reducing remedy that would prevent all three.
'inflammation theory': Immune-system errors linked to more illnesses
"Medical researchers are becoming increasingly convinced that the most
primitive part of the immune system (inflammation), may play a crucial role in
some of the most devastating afflictions of modern humans, including heart
disease, cancer, diabetes and possibly Alzheimer's."
Obesity is Inflammatory Disease, Rat Study Shows
led by Dr David Fairlie from the University of Queensland, Australia,
have found abnormal amounts of an inflammatory protein called PAR2 in
the fat tissues of overweight and obese rats and humans.
PAR2 is also increased on the surfaces of human immune cells by
common fatty acids in the diet. When obese rats on a diet high in sugar
and fat were given a new oral drug that binds to PAR2, the
inflammation-causing properties of this protein were blocked, as were
other effects of the high-fat and high-sugar diet, including obesity
evolution give us inflammatory disease?
American Journal of Human Genetics
Researchers demonstrate that some variants in our genes that could put a
person at risk for inflammatory diseases such as multiple sclerosis,
Crohn's disease or rheumatoid arthritis, have been the target of natural
selection over the course of human history. The findings suggest that in
the past these variants rose in frequency in the human population to
help protect us against viruses, bacteria and other pathogens. But now
in our modern world, the environment and exposure to pathogens has
changed, and the genetic variants that were originally meant to protect
us, now make an autoimmune reaction more likely.
Curcuminat M.D. Anderson Cancer Center The University of Texas, MD
Curcumin has been shown to prevent a large of number of cancers
in animal studies. Laboratory data indicate that Curcumin can
inhibit tumor initiation, promotion, invasion, angiogenesis and
Epidemiological evidence indicate that
incidence of certain cancers is less in people who consume Curcumin
than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the
treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and
anti-inflammatory effects at M. D. Anderson Cancer Center and other
Healer Scientific American Magazine
An ingredient in
curry shows promise for treating Alzheimer's, cancer and other diseases. "A chapter in a forthcoming book, for instance, describes the
biologically active components of Turmeric--Curcumin and related
compounds called Curcuminoids--as having antioxidant,
anti-inflammatory, antiviral, antibacterial and antifungal properties,
with potential activity against cancer, diabetes, arthritis, Alzheimer's
disease and other chronic maladies. And in 2005 nearly 300 scientific
and technical papers referenced Curcumin in the National Library
of Medicine's PubMed database, compared with about 100 just five years
earlier. Scientists who sometimes jokingly label
themselves Curcuminologists are drawn to the compound both
because of its many possible valuable effects in the body and its
apparent low toxicity. They ponder how the spice or its derivatives
might be used, not just as a treatment but as a low-cost preventive
medication for some of the most feared ailments. As a treatment, it also
has some enticing attributes. Because Curcumin targets so many
biological pathways, it could have benefits for cancer therapy:
malignant cells may be slow to acquire resistance to it and so might
have to go through multiple mutations to avoid the substance's
Previous news and studies on Curcumin and Turmeric.
Scientific journals with published studies of Curcumin and Turmeric.
American Journal of Physiology - 277: 320-29
Age - 18:167-9 Agents and Actions - 28:298-303
Alimentary Pharmacology and Therapeutics - 13(2):245-249
Alternative Medicine Review - 4(3):178-88, 6(2):167-187, 7(5):404-9
American Journal of Clinical Nutrition - 64(5):761-766 American Journal of Physiology: Gastrointestinal and Liver Physiology 284(1):85-95,
American Surgeon - 64(1):47-51 Annals of the New York Academy of Sciences - 973:250-4
Anticancer Drugs - 8(5):470-81
Anti Cancer Research - 11: 593-596, 19(5A):3675-80, 20(3a):1733-8, more
What is Turmeric-Curcumin.com?
is our company and website, dedicated since 2000 to offering the highest quality
Curcumin 95% extract,
the best customer
lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5
remain dedicated and focused on the most powerful, healthful and important
compound in botanical medicine; Curcumin, concentrated and standardized
to 95% purified extract. This extraordinary spice extract has generated such
interest that universities and medical centers around the world are continually conducting
research studies and discovering new benefits, with multiple ongoing human clinical
trials. Due to it's potent antioxidant power, Curcumin has been recognized as
one of the most promising food-derived compounds in fighting a variety of
degenerative diseases. The scientific evidence remains overwhelming, demonstrating
the many health benefits via in vitro, in vivo and human clinical studies.
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